Generic chromatography-based purification strategies accelerate the development of downstream processes for biopharmaceutical proteins produced in plants

Biotechnology Journal

Volumn 9, Issue 4, 2014, Pages 566-577

  Buyel, Johannes F ^a   Fischer, Rainer ^a,b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

Author keywords

Bioprocess development; Host cell protein separation; Liquid chromatography; Plant derived biopharmaceuticals; Protein purification

Indexed keywords

LIGANDS; LIQUID CHROMATOGRAPHY; PLANT EXTRACTS; PRODUCTION PLATFORMS; PURIFICATION; RESINS; TOBACCO;

BIOPHARMACEUTICAL PROTEINS; BIOPHARMACEUTICALS; BIOPROCESS DEVELOPMENT; CHROMATOGRAPHY RESIN; DIVERSE PROPERTIES; DOWNSTREAM PROCESS; HOST CELL PROTEIN; PROTEIN PURIFICATION;

RECOMBINANT PROTEINS;

CELL PROTEIN; HEXYLAMINE; HOST CELL PROTEIN; PLANT EXTRACT; RECOMBINANT PROTEIN; RESIN; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

ANION EXCHANGE; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; BINDING SITE; CATION EXCHANGE; CHROMATOGRAPHY; CONDUCTANCE; CONTROLLED STUDY; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; ION EXCHANGE CHROMATOGRAPHY; MIXED MODE CHROMATOGRAPHY; MOLECULAR WEIGHT; NONHUMAN; PH; PLANT LEAF; PLANT SEED; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PURIFICATION; SALT TOLERANCE; SALT TOLERANT CHROMATOGRAPHY; SURFACE CHARGE; TOBACCO; BIOTECHNOLOGY; CHEMISTRY; ISOLATION AND PURIFICATION; LIQUID CHROMATOGRAPHY; METABOLISM; PROCEDURES; TRANSGENIC PLANT;

MAMMALIA; NICOTIANA TABACUM;

BIOTECHNOLOGY; CHROMATOGRAPHY, LIQUID; PLANT EXTRACTS; PLANT PROTEINS; PLANTS, GENETICALLY MODIFIED; RECOMBINANT PROTEINS; TOBACCO;

EID: 84897452385     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201300548     Document Type: Article

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