Scale-down models to optimize a filter train for the downstream purification of recombinant pharmaceutical proteins produced in tobacco leaves

Biotechnology Journal

Volumn 9, Issue 3, 2014, Pages 415-425

  Buyel, Johannes F ^a   Fischer, Rainer ^a,b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

Author keywords

Biopharmaceuticals; Bioprocesses; Filtration; Protein extraction; Transgenic plants

Indexed keywords

EXTRACTION; FILTRATION; FLUORESCENCE; MONOCLONAL ANTIBODIES; PLANT EXTRACTS; PURIFICATION; TOBACCO;

BIOPHARMACEUTICAL PROTEINS; BIOPHARMACEUTICALS; BIOPROCESSES; DOWNSTREAM PURIFICATIONS; GOOD MANUFACTURING PRACTICES; PROTEIN EXTRACTION; SURFACE PLASMON RESONANCE SPECTROSCOPY; TRANSGENIC PLANTS;

RECOMBINANT PROTEINS;

PLANT EXTRACT; RECOMBINANT PROTEIN;

ARTICLE; BIOPROCESS; DRUG PURIFICATION; FILTER; FILTRATION; FLUORESCENCE; GOOD MANUFACTURING PRACTICE; NICOTIANA BENTHAMIANA; PRIORITY JOURNAL; SURFACE PLASMON RESONANCE; TOBACCO; TRANSGENIC PLANT; TURBIDITY;

NICOTIANA TABACUM;

BIOPHARMACEUTICALS; BIOPROCESSES; FILTRATION; PROTEIN EXTRACTION; TRANSGENIC PLANTS;

BIOREACTORS; FILTRATION; HUMANS; MODELS, THEORETICAL; PLANT LEAVES; PLANTS, GENETICALLY MODIFIED; RECOMBINANT PROTEINS; SURFACE PLASMON RESONANCE; TOBACCO;

EID: 84897584250     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201300369     Document Type: Article

References (51)

1. Fischer, R., Schillberg, S., Hellwig, S., Twyman, R. M., Drossard, J., GMP issues for recombinant plant-derived pharmaceutical proteins. Biotechnol. Adv. 2012, 30, 434-439.
2. Fischer, R., Schillberg, S., Buyel, J. F., Twyman, R. M., Commercial aspects of pharmaceutical protein production in plants. Curr. Pharm. Des. 2013, 19, 5471-5477.
3. Laukel, M., Rogge, P., Dudziak, G., Disposable downstream processing for clinical manufacturing. BioProcess Int. 2011, 9, 14-21.
4. Whitford, W. G., Single-use systems as principal components in bioproduction. BioProcess Int. 2010, 8, 34-44.
5. Yigzaw, Y., Piper, R., Tran, M., Shukla, A. A., Exploitation of the adsorptive properties of depth filters for host cell protein removal during monoclonal antibody purification. Biotechnol. Prog. 2006, 22, 288-296.
6. Pegel, A., Reiser, S., Steurenthaler, M., Klein, S., Evaluating disposable depth filtration platforms for mAb harvest clarification. BioProcess Int. 2011, 9, 52-56.
7. O'Brien, T. P., Brown, L. A., Battersby, D. G., Rudolph, A. S., Raman, L. P., Large-scale, single-use depth filtration systems for mammalian cell culture clarification. BioProcess Int. 2012, 10, 50-57.
8. Gottschalk, U., Process Scale Purification of Antibodies John Wiley & Sons, Hoboken, New Jersey 2009.
9. Roush, D. J., Lu, Y. F., Advances in primary recovery: Centrifugation and membrane technology. Biotechnol. Prog. 2008, 24, 488-495.
10. Bradford, S. A., Yates, S. R., Bettahar, M., Simunek, J., Physical factors affecting the transport and fate of colloids in saturated porous media. Water Resour. Res. 2002, 38, 1327.
11. Johnson, W. P., Li, X. Q., Yal, G., Colloid retention in porous media: Mechanistic confirmation of wedging and retention in zones of flow stagnation. Environ. Sci. Technol. 2007, 41, 1279-1287.
12. Buyel, J. F., Bautista, J. A., Fischer, R., Yusibov, V. M., Extraction, purification and characterization of the plant-produced HPV16 subunit vaccine candidate E7 GGG. J. Chromatogr. B 2012, 880, 19-26.
13. Main, G. D., Reynolds, S., Gartland, J. S., Electroporation protocols for Agrobacterium. Methods Mol. Biol. 1995, 44, 405-412.
14. Holland, T., Sack, M., Rademacher, T., Schmale, K. et al., Optimal nitrogen supply as a key to increased and sustained production of a monoclonal full-size antibody in BY-2 suspension culture. Biotechnol. Bioeng. 2010, 107, 278-289.
15. Buyel, J. F., Fischer, R., Predictive models for transient protein expression in tobacco (Nicotiana tabacum L.) can optimize process time, yield, and downstream costs. Biotechnol. Bioeng. 2012, 109, 2575-2588.
16. Bradford, M. M., Simonian, M. H., Smith, J. A., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-254.
17. Simonian, M. H., Smith, J. A., Spectrophotometric and colorimetric determination of protein concentration. Curr. Protoc. Mol. Biol. 2006, Chapter10, Unit 10 11A.
18. Howell, S., Kenmore, M., Kirkland, M., Badley, R. A., High-density immobilization of an antibody fragment to a carboxymethylated dextran-linked biosensor surface. J. Mol. Recogn. 1998, 11, 200-203.
19. Piliarik, M., Vaisocherova, H., Homola, J., Surface plasmon resonance biosensing. Methods Mol. Biol. 2009, 503, 65-88.
20. Lobedann, M., Molecular Biotechnology, PhD thesis, RWTH Aachen University, Aachen 2009.
21. Ghidaglia, C., de Arcangelis, L., Hinch, J., Guazzelli, E., Hydrodynamic interactions in deep bed filtration. Phys. Fluids 1996, 8, 6-14.
22. Smith, G. W., Tavlarides, L. L., Placek, J., Turbulent-flow in stirred tanks: scale-up computations for vessel hydrodynamics. Chem. Eng. Commun. 1990, 93, 49-73.
23. Paul, E. L., Atiemo-Obeng, V., Kresta, S. M., Handbook of Industrial Mixing: Science and Practice, Wiley 2004.
24. Giglia, S., Yavorsky, D., Scaling from discs to pleated devices. J. Pharm. Sci. Technol. 2007, 61, 314-323.
25. Giglia, S., Sciola, L., Scaling up normal-flow microfiltration processes. BioProcess Int. 2011, 9, 58-60.
26. Dullien, F. A. L., Maximizing the capacity and fife of depth-type filters. Can. J. Chem. Eng. 1989, 67, 689-692.
27. Hanen, F., Ksouri, R., Megdiche, W., Trabelsi, N. et al., Effect of salinity on growth, leaf-phenolic content and antioxidant scavenging activity in Cynara cardunculus L, Biosaline Agriculture and High Salinity Tolerance, Birkhuser, Basel 2008, pp. 335-343.
28. Neves, G. Y. S., Marchiosi, R., Ferrarese, M. L. L., Siqueira-Soares, R. C., Ferrarese, O., Root growth inhibition and lignification induced by salt stress in soybean. J. Agron. Crop. Sci. 2010, 196, 467-473.
29. Huh, N. W., Porter, N. A., McIntosh, T. J., Simon, S. A., The interaction of polyphenols with bilayers: Conditions for increasing bilayer adhesion. Biophys. J. 1996, 71, 3261-3277.
30. Nakayama, T., Hashimoto, T., Kajiya, K., Kumazawa, S., Affinity of polyphenols for lipid bilayers. BioFactors 2000, 13, 147-151.
31. Graupner, N., Application of lignin as natural adhesion promoter in cotton fibre-reinforced poly(lactic acid) (PLA) composites. J. Mater. Sci. 2008, 43, 5222-5229.
32. Pocius, A. V., Chaudhury, M., Surfaces, Chemistry and Applications: Adhesion Science and Engineering, Elsevier 2002.
33. McIntosh, T., Pollastri, M., Porter, N., Simon, S., Polyphenols Increase Adhesion Between Lipid Bilayers by Forming Interbilayer Bridges, in: Gross, G., Hemingway, R., Yoshida, T., Branham, S. (Eds.), Plant Polyphenols 2, Springer US 2000, pp. 451-470.
34. Caffall, K. H., Mohnen, D., The structure, function, and biosynthesis of plant cell wall pectic polysaccharides. Carbohydr. Res. 2009, 344, 1879-1900.
35. Iraki, N. M., Bressan, R. A., Hasegawa, P. M., Carpita, N. C., Alteration of the physical and chemical-structure of the primary-cell wall of growth-limited plant-cells adapted to osmotic-stress. Plant Physiol. 1989, 91, 39-47.
36. Iraki, N. M., Singh, N., Bressan, R. A., Carpita, N. C., Cell-walls of tobacco cells and changes in composition associated with reduced growth upon adaptation to water and saline stress. Plant Physiol. 1989, 91, 48-53.
37. Keutgen, A. J., Pawelzik, E., Cultivar-dependent cell wall modification of strawberry fruit under NaCl salinity stress. J. Agric. Food Chem. 2007, 55, 7580-7585.
38. Zsivanovits, G., MacDougall, A. J., Smith, A. C., Ring, S. G., Material properties of concentrated pectin networks. Carbohydr. Res. 2004, 339, 1317-1322.
39. Matia-Merino, L., Lau, K., Dickinson, E., Effects of low-methoxyl amidated pectin and ionic calcium on rheology and microstructure of acid-induced sodium caseinate gels. Food Hydrocolloid. 2004, 18, 271-281.
40. Pruss, G. J., Nester, E. W., Vance, V., Infiltration with Agrobacterium tumefaciens induces host defense and development-dependent responses in the infiltrated zone. Mol. Plant-Microbe Interact. 2008, 21, 1528-1538.
41. Baird, G. S., Zacharias, D. A., Tsien, R. Y., Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral. Proc. Natl. Acad. Sci. USA 2000, 97, 11984-11989.
42. Murphy, K. P., Travers, P., Walport, M., Janeway, C., Janeway's immunobiology Garland Science, New York, NY, USA 2008.
43. Sahin, E., Grillo, A. O., Perkins, M. D., Roberts, C. J., Comparative effects of pH and ionic strength on protein-protein interactions, unfolding, and aggregation for IgG1 antibodies. J. Pharm. Sci. 2010, 99, 4830-4848.
44. Rathore, A. S., Joshi, V., Yadav, N., Aggregation of monoclonal antibody products: Formation and removal. BioPharm Int. 2013, 26, 40-45.
45. Bevis, B. J., Glick, B. S., Rapidly maturing variants of the Discosoma red fluorescent protein (DsRed). Nat. Biotechnol. 2002, 20, 83-87.
46. Yanushevich, Y. G., Staroverov, D. B., Savitsky, A. P., Fradkov, A. F. et al., A strategy for the generation of non-aggregating mutants of Anthozoa fluorescent proteins. FEBS Lett. 2002, 511, 11-14.
47. Clontech Laboratories, Living Colors® User Manual Vol. II: Reef Coral Fluorescent Proteins, Clontech Laboratories, Inc., Mountain View, CA, USA 2003.
48. Jach, G., Binot, E., Frings, S., Luxa, K., Schell, J., Use of red fluorescent protein from Discosoma sp (dsRED) as a reporter for plant gene expression. Plant J. 2001, 28, 483-491.
49. Sajadi, M. M., Lewis, G. K., Seaman, M. S., Guan, Y. J. et al., Signature biochemical properties of broadly cross-reactive HIV-1 neutralizing antibodies in human plasma. J. Virol. 2012, 86, 5014-5025.
50. Boulton, R. B., Singleton, V. L., Bisson, L. F., Principles and Practices of Winemaking Springer 1998.
51. Tanaka, M., Hermann, J., Haase, I., Fischer, M., Boxer, S. G., Frictional drag and electrical manipulation of recombinant proteins in polymer-supported membranes. Langmuir 2007, 23, 5638-5644.