Adsorption of deamidated antibody variants on macroporous and dextran-grafted cation exchangers: II. Adsorption kinetics

Journal of Chromatography A

Volumn 1218, Issue 11, 2011, Pages 1530-1537

  Tao, Yinying ^a   Carta, Giorgio ^a   Ferreira, Gisela ^b   Robbins, David ^b  

^a University of Virginia   (United States)

^b MEDIMMUNE   (United States)

Author keywords

Ion exchange; Mass transfer modeling; Monoclonal antibody charge variants; Multicomponent adsorption kinetics

Indexed keywords

ADSORPTION KINETICS; ADSORPTION RATES; APPROACH TO EQUILIBRIUM; BATCH ADSORPTION; CATION EXCHANGERS; DEAMIDATED; DIFFUSION MODEL; DISPLACEMENT PROCESS; DRIVING FORCES; EFFECTIVE DIFFUSIVITIES; EQUILIBRIUM VALUE; FREE SOLUTION DIFFUSIVITY; IN-PROCESS; MACROPOROUS; MACROPOROUS RESIN; MACROPOROUS STRUCTURES; MASS TRANSFER MODELING; MATRIX; MULTICOMPONENT ADSORPTION; MULTICOMPONENTS; MULTIPLE VARIANTS; PORE DIFFUSION; SINGLE COMPONENTS; THREE-COMPONENT SYSTEM;

DEXTRAN; DIFFUSION; GLUCOSE; GRAFTING (CHEMICAL); ION EXCHANGE; ION EXCHANGERS; MONOCLONAL ANTIBODIES; PHASE EQUILIBRIA; POSITIVE IONS; RESINS; SURFACE PLASMON RESONANCE;

ADSORPTION;

CAPTO S; DEXTRAN; MONOCLONAL ANTIBODY; RESIN; UNCLASSIFIED DRUG; UNOSPHERE S;

ADSORPTION; ARTICLE; CATION EXCHANGE; CHEMICAL BINDING; DEAMINATION; FLOW RATE; ION EXCHANGE CHROMATOGRAPHY; ISOELECTRIC FOCUSING; KINETICS; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; POROSITY; PRIORITY JOURNAL;

ADSORPTION; CHROMATOGRAPHY, ION EXCHANGE; DEXTRANS; KINETICS;

EID: 79951713158     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.01.050     Document Type: Article

References (46)

1. Tao Y., Carta G., Ferreira G., Robbins D. J. Chromatogr. A 2011, 1218:1519-1529.
2. Harris R.J., Kabakoff B., Macchi F.D., Shen F.J., Kwong M., Andya J.D., Shire S.J., Bjork N., Totpal K., Chen A.B. J. Chromatogr. B 2001, 752:233.
3. Liu H., Gaza-Bulseco G., Chumsae C. Rapid Commun. Mass Spectrom. 2008, 22:4081.
4. Roque A.C.A., Lowe C.R., Taipa M.A. Biotechnol. Progr. 2004, 20:639.
5. Tugcu N., Roush D.J., Goklen K.E. Biotechnol. Bioeng. 2008, 99:599.
6. Weitzhandler M., Farnan D., Horvath J., Rohrer J.S., Slingsby R.W., Avdalovic N., Pohl C. J. Chromatogr. A 1998, 828:365.
7. Perkins M., Theiler R., Lunte S., Jeschke M. Pharm. Res. 2000, 17:1110.
8. Weitzhandler M., Farnan D., Rohrer J.S., Avdalovic N. Proteomics 2001, 1:197.
9. Melter L., Strohlein G., Butte A., Morbidelli M. J. Chromatogr. A 2007, 1154:121.
10. Ladisch M.E. Bioseparations Engineering - Principles, Practice and Economics 2001, Wiley Interscience, New York, USA.
11. Carta G., Jungbauer A. Protein chromatography-Process development and Scale-up 2010, Wiley-VCH, Weinheim, Germany.
12. Carta G., Ubiera A.R., Pabst T.M. Chem. Eng. Technol. 2005, 28:1252.
13. Lenhoff A.M. Langmuir 2008, 24:5991.
14. Weaver L.E., Carta G. Biotechnol. Progr. 1996, 12:342.
15. Chang C., Lenhoff A.M. J. Chromatogr. A 1998, 827:281.
16. Lewus R.K., Carta G. J. Chromatogr. A 1999, 865:155.
17. Dziennik S.R., Belcher E.B., Barker G.A., de Bergalis M.J., Fernandez S.E., Lenhoff A.M. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:420.
18. Zhou X.P., Li W., Shi Q.H., Sun Y. J. Chromatogr. A 2006, 1103:110.
19. Schirmer E.B., Carta G. AIChE J. 2007, 53:1472.
20. Stone M.C., Carta G. J. Chromatogr. A 2007, 1160:206.
21. Hunter A.K., Carta G. J. Chromatogr. A 2002, 971:105.
22. Dziennik S.R., Belcher E.B., Barker G.A., Lenhoff A.M. Biotechnol. Bioeng. 2005, 91:139.
23. Stone M.C., Tao Y., Carta G. J. Chromatogr. A 2009, 1216:1216.
24. Lewus R.K., Carta G. Ind. Eng. Chem. Res. 2001, 40:1548.
25. Russell S., Belcher E.B., Carta G. AIChE J. 2003, 49:1168.
26. Stone M.C., Carta G. J. Chromatogr. A 2007, 1146:202.
27. Yang K., Sun Y. Biochem. Eng. J. 2007, 37:298.
28. Tao Y., Carta G. J. Chromatogr. A 2008, 1211:70.
29. LeVan M.D., Carta G. Perry's Chemical Engineers' Handbook 2007, McGraw-Hill, New York, (Section 16). 8th ed. D.W. Green (Ed.).
30. Phillips R.J., Deen W.M., Brady J.F. AIChE J. 1989, 35:1761.
31. Smith F.G., Deen W.M. J. Coll. Int. Sci. 1983, 91:571.
32. Yoshida H., Yoshikawa M., Kataoka T. AIChE J. 1994, 40:2034.
33. Hunter A.K., Carta G. J. Chromatogr. A 2000, 897:81.
34. P.D. Robbins, A dynamic approach to protein purification by adsorption, PhD Thesis, Massachusetts Institute of Technology, Cambridge, MA, USA, 1989.
35. Martin C., Iberer G., Ubiera A., Carta G. J. Chromatogr. A 2005, 1079:105.
36. Linden T., Ljunglof A., Kula M.R., Thommes J. Biotechnol. Bioeng. 1999, 65:622.
37. Gallant S.R. J. Chromatogr. A 2004, 1028:189.
38. Lewus R.K., Carta G. AIChE J. 1999, 45:512.
39. Russell S.M., Carta G. AIChE J. 2005, 51:2469.
40. Forrer N., Butte A., Morbidelli M. J. Chromatogr. A 2008, 1214:71.
41. Cussler E.L. Diffusion - Mass Transfer in Fluid Systems 1997, Cambridge University Press, Cambridge, UK. 2nd ed.
42. Brooks C.A., Cramer S.M. AIChE J. 1992, 38:1969.
43. Thommes J. Biotechnol. Bioeng. 1999, 61:358.
44. Ubiera A., Carta G. Biotechnol. J. 2006, 1:665.
45. Helfferich F. Ion Exchange 1962, McGraw-Hill, New York, USA.
46. Cussler E.L., Aris R., Bhown A. J. Membr. Sci. 1989, 43:149.