A high-throughput 2D-analytical technique to obtain single protein parameters from complex cell lysates for in silico process development of ion exchange chromatography

Journal of Chromatography A

Volumn 1318, Issue , 2013, Pages 84-91

  Kröner, Frieder ^a   Elsäßer, Dennis ^a   Hubbuch, Jürgen ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

High throughput; In silico; Ion exchange chromatography; Multi dimensional analysis; Protein purification; Steric mass action

Indexed keywords

CAPILLARY ELECTROPHORESIS; CHROMATOGRAPHIC ANALYSIS; COMMERCE; ELECTROLYTES; ION CHROMATOGRAPHY; ION EXCHANGE; IONS; THROUGHPUT;

CELL LYSATES; GRADIENT ANION-EXCHANGE CHROMATOGRAPHY; HIGH-THROUGHPUT; IN-SILICO; ION EXCHANGE CHROMATOGRAPHY; MULTI-DIMENSIONAL ANALYSIS; PROCESS DEVELOPMENT; PROTEIN PURIFICATION; SALT-GRADIENTS; STERIC MASS ACTION;

PROTEINS;

NUCLEOLIN;

ANIMAL CELL; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; CELL LYSATE; COMPUTER MODEL; GEL ELECTROPHORESIS; HIGH THROUGHPUT SCREENING; INSECT CELL; MATHEMATICAL MODEL; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROTEIN ANALYSIS; SEPARATION TECHNIQUE;

HIGH-THROUGHPUT; IN SILICO; ION EXCHANGE CHROMATOGRAPHY; MULTI-DIMENSIONAL ANALYSIS; PROTEIN PURIFICATION; STERIC MASS-ACTION;

ANIMALS; CHROMATOGRAPHY, ION EXCHANGE; COMPUTER SIMULATION; INSECT PROTEINS; SPODOPTERA;

EID: 84887133945     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2013.09.043     Document Type: Article

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