Flocculation increases the efficacy of depth filtration during the downstream processing of recombinant pharmaceutical proteins produced in tobacco

Plant Biotechnology Journal

Volumn 12, Issue 2, 2014, Pages 240-252

  Buyel, Johannes F ^a   Fischer, Rainer ^a,b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

Author keywords

Design of experiments; Downstream processing; Flocculation; Monoclonal antibody; Plant derived biopharmaceuticals; Process development

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS; NICOTIANA TABACUM;

MONOCLONAL ANTIBODY; PLANT EXTRACT; POLYMER; RECOMBINANT PROTEIN;

ARTICLE; BIOTECHNOLOGY; CELL AGGREGATION; COMPARATIVE STUDY; CULTURE TECHNIQUE; DESIGN OF EXPERIMENTS; DOWNSTREAM PROCESSING; FILTRATION; FLOCCULATION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PLANT-DERIVED BIOPHARMACEUTICALS; PROCESS DEVELOPMENT; TOBACCO;

DESIGN OF EXPERIMENTS; DOWNSTREAM PROCESSING; FLOCCULATION; MONOCLONAL ANTIBODY; PLANT-DERIVED BIOPHARMACEUTICALS; PROCESS DEVELOPMENT;

ANTIBODIES, MONOCLONAL; BIOTECHNOLOGY; CELL AGGREGATION; CELL CULTURE TECHNIQUES; FILTRATION; FLOCCULATION; MOLECULAR SEQUENCE DATA; PLANT EXTRACTS; POLYMERS; RECOMBINANT PROTEINS; TOBACCO;

EID: 84892885187     PISSN: 14677644     EISSN: 14677652     Source Type: Journal    
DOI: 10.1111/pbi.12132     Document Type: Article

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