Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists

Journal of Medicinal Chemistry

Volumn 56, Issue 16, 2013, Pages 6434-6456

  Acker, Timothy M ^a,b   Khatri, Alpa ^b   Vance, Katie M ^b   Slabber, Cathryn ^a   Bacsa, John ^a   Snyder, James P ^a   Traynelis, Stephen F ^b   Liotta, Dennis C ^a  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [1 (3 CARBOXYPROPANOYL) 3 (6 CHLORO 2 OXO 4 PHENYL 1,2 DIHYDROQUINOLIN 3 YL) 4,5 DIHYDRO 1H PYRAZOL 5 YL]BENZOIC ACID; 4 [3 (6 CHLORO 2 OXO 4 PHENYL 1,2 DIHYDROQUINOLIN 3 YL) 5 (2 CHLORPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 OXOBUTANOIC ACID; 4 [3 (6 CHLORO 2 OXO 4 PHENYL 1,2 DIHYDROQUINOLIN 3 YL) 5 (3 CHLOROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 OXOBUTANOIC ACID; 4 [3 (6 CHLORO 2 OXO 4 PHENYL 1,2 DIHYDROQUINOLIN 3 YL) 5 (3 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 OXOBUTANOIC ACID; 4 [3 (6 CHLORO 2 OXO 4 PHENYL 1,2 DIHYDROQUINOLIN 3 YL) 5 (4 CHLOROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 OXOBUTANOIC ACID; 4 [3 (6 CHLORO 2 OXO 4 PHENYL 1,2 DIHYDROQUINOLIN 3 YL) 5 (4 FLUOROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 OXOBUTANOIC ACID; 4 [3 (6 CHLORO 2 OXO 4 PHENYL 1,2 DIHYDROQUINOLIN 3 YL) 5 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 OXOBUTANOIC ACID; 4 [3 (6 CHLORO 2 OXO 4 PHENYL 1,2 DIHYDROQUINOLIN 3 YL) 5 [4 (METHOXYCARBONYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 OXOBUTANOIC ACID; 4 [3 (6 CHLORO 2 OXO 4 PHENYL 1,2 DIHYDROQUINOLIN 3 YL) 5 [4 (TRIFLUOROMETHYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 OXOBUTANOIC ACID; 4 [3 [4 (4 BROMOPHENYL) 2 OXO 1,2 DIHYDROQUINOLIN 3 YL] 5 (4 CHLOROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 OXOBUTANOIC ACID; 4 [3 [4 (4 BROMOPHENYL) 2 OXO 1,2 DIHYDROQUINOLIN 3 YL] 5 (4 FLUOROPHENYL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 OXOBUTANOIC ACID; 4 [5 (2 BROMOPHENYL) 3 (6 CHLORO 2 OXO 4 PHENYL 1,2 DIHYDROQUINOLIN 3 YL) 4,5 DIHYDRO 1H PYRAZOL 1 YL] 4 OXOBUTANOIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; AMPA RECEPTOR; DQP 1105; GLUTAMATE RECEPTOR N1; GLUTAMATE RECEPTOR N2A; GLUTAMATE RECEPTOR N2B; GLUTAMATE RECEPTOR N2C; GLUTAMATE RECEPTOR N2D; GLYCINE RECEPTOR; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NICOTINIC RECEPTOR; PURINERGIC RECEPTOR; PYRAZOLINE DERIVATIVE; QNZ 46; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HUMAN; HUMAN CELL; IC 50; NONHUMAN; NUCLEOTIDE SEQUENCE; PHARMACOPHORE; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

BLOOD-BRAIN BARRIER; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; MICROSOMES, LIVER; MODELS, MOLECULAR; PYRAZOLES; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84883198508     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400652r     Document Type: Article

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