Diamidine compounds for selective inhibition of protein arginine methyltransferase 1

Journal of Medicinal Chemistry

Volumn 57, Issue 6, 2014, Pages 2611-2622

  Yan, Leilei ^a,e   Yan, Chunli ^b   Qian, Kun ^a   Su, Hairui ^c   Kofsky Wofford, Stephanie A ^b   Lee, Wei Chao ^d   Zhao, Xinyang ^c   Ho, Meng Chiao ^d   Ivanov, Ivaylo ^b   Zheng, Yujun George ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b GEORGIA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^e HEBEI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2,5 BIS(4 AMIDINOPHENYL)FURAN; DIAMIDINE DERIVATIVE; PROTEIN ARGININE METHYLTRANSFERASE;

ARTICLE; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG SPECIFICITY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MOLECULAR DOCKING; MOLECULAR DYNAMICS;

BINDING, COMPETITIVE; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; CELL SURVIVAL; COMPUTER SIMULATION; ENZYME INHIBITORS; FLUORESCENCE POLARIZATION; HUMANS; IMMUNOPRECIPITATION; KINETICS; LEUKEMIA; MODELS, MOLECULAR; PENTAMIDINE; PROTEIN BINDING; PROTEIN-ARGININE N-METHYLTRANSFERASES; REPRESSOR PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84897416751     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401884z     Document Type: Article

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