In situ generation of a bisubstrate analogue for protein arginine methyltransferase 1

Journal of the American Chemical Society

Volumn 130, Issue 14, 2008, Pages 4574-4575

  Osborne, Tanesha ^a   Roska, Rachel L Weller ^a   Rajski, Scott R ^a   Thompson, Paul R ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

5' (DIAMINOBUTYRIC ACID) N IODOETHYL 5' DEOXYADENOSINE AMMONIUM; ARGININE METHYLTRANSFERASE INHIBITOR 1; METHYLTRANSFERASE INHIBITOR; PROTEIN ARGININE METHYLTRANSFERASE; PROTEIN ARGININE METHYLTRANSFERASE INHIBITOR; S ADENOSYLHOMOCYSTEINE; SINEFUNGIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; METHYLATION;

DEOXYADENOSINES; ENZYME INHIBITORS; ISOENZYMES; KINETICS; PEPTIDES; PROTEIN-ARGININE N-METHYLTRANSFERASE; REPRESSOR PROTEINS; SUBSTRATE SPECIFICITY;

EID: 41849105766     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja077104v     Document Type: Article

References (21)

1. (a) Bedford, M. T.; Richard, S. Mol. Cell 2005, 18, 263-272.
2. (b) Krause, C. D.; Yang, Z. H.; Kim, Y. S.; Lee, J. H.; Cook, J. R.; Pestka, S. Pharmacol. Ther. 2007, 113, 50-87.
3. (a) Wang, H.; Huang, Z.-Q.; Xia, L.; Feng, Q.; Erdjument-Bromage, H.; Strahl, B. D.; Briggs, S. D.; Allis, C. D.; Wong, J.; Tempst, P.; Zhang, Y. Science 2001, 293, 853-857.
4. (b) Chen, D.; Ma, H.; Hong, H.; Koh, S. S.; Huang, S. M.; Schurter, B. T.; Aswad, D. W.; Stallcup, M. R. Science 1999, 284, 2174-2177.
5. (c) An, W.; Kim, J.; Roeder, R. G. Cell 2004, 117, 735-748.
6. (a) Vallance, P.; Leiper, J. Arterioscler. Thromb. Vasc. Biol. 2004, 24, 1023-1030.
7. (b) Hong, H.; Kao, C.; Jeng, M. H.; Eble, J. N.; Koch, M. O.; Gardner, T. A.; Zhang, S.; Li, L.; Pan, C. X.; Hu, Z.; MacLennan, G. T.; Cheng, L. Cancer 2004, 101, 83-89.
8. Chen, X.; Niroomand, F.; Liu, Z.; Zankl, A.; Katus, H. A.; Jahn, L.; Tiefenbacher, C. P. Basic Res. Cardiol. 2006, 101, 346-353.
9. Osborne, T. C.; Obianyo, O.; Zhang, X.; Cheng, X.; Thompson, P. R. Biochemistry 2007, 46, 13370-13381.
10. (a) Lin, Q.; Jiang, F.; Schultz, P. G.; Gray, N. S. J. Am. Chem. Soc. 2001, 123, 11608-11613.
11. (b) Spannhoff, A.; Heinke, R.; Bauer, I.; Trojer, P.; Metzger, E.; Gust, R.; Schule, R.; Brosch, G.; Sippl, W.; Jung, M. J. Med. Chem. 2007, 50, 2319-2325.
12. (c) Spannhoff, A.; Machmur, R.; Heinke, R.; Trojer, P.; Bauer, I.; Brosch, G.; Schule, R.; Hanefeld, W.; Sippl, W.; Jung, M. Bioorg. Med. Chem. Lett. 2007, 17, 4150-4153.
13. (d) Mai, A.; Valente, S.; Cheng, D.; Perrone, A.; Ragno, R.; Simeoni, S.; Sbardella, G.; Brosch, G.; Nebbioso, A.; Conte, M.; Altucci, L.; Bedford, M. T. ChemMedChem 2007, 2, 987-991.
14. Cheng, D.; Yadav, N.; King, R. W.; Swanson, M. S.; Weinstein, E. J.; Bedford, M. T. J. Biol. Chem. 2004, 279, 23892-23899.
15. Skillman, A. G.; Maurer, K. W.; Roe, D. C.; Stauber, M. J.; Eargle, D.; Ewing, T. J.; Muscate, A.; Davioud-Charvet, E.; Medaglia, M. V.; Fisher, R. J.; Arnold, E.; Gao, H. Q.; Buckheit, R.; Boyer, P. L.; Hughes, S. H.; Kuntz, I. D.; Kenyon, G. L. Bioorg. Chem. 2002, 30, 443-458.
16. (a) Weller, R. L.; Rajski, S. R. Chembiochem 2006, 7, 243-245.
17. (b) Zhang, C.; Weller, R. L.; Thorson, J. S.; Rajski, S. R. J. Am. Chem. Soc. 2006, 128, 2760-2761.
18. Strahl, B. D.; Briggs, S. D.; Brame, C. J.; Caldwell, J. A.; Koh, S. S.; Ma, H.; Cook, R. G.; Shabanowitz, J.; Hunt, D. F.; Stallcup, M. R.; Allis, C. D. Curr. Biol. 2001, 11, 996-1000.
19. Zheng, Y.; Thompson, P. R.; Cebrat, M.; Wang, L.; Devlin, M. K.; Alani, R. M.; Cole, P. A. Methods Enzymol. 2004, 376, 188-199.
20. Trehin, R.; Merkle, H. P. Eur. J. Pharm. Biopharm. 2004, 58, 209-223.
21. Weller, R. L. Ph.D. Thesis, University of Wisconsin, 2006.