A novel blood-brain barrier co-culture system for drug targeting of Alzheimer's disease: Establishment by using acitretin as a model drug

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Freese, Christian ^a   Reinhardt, Sven ^a   Hefner, Gudrun ^a   Unger, Ronald E ^a   Kirkpatrick, C James ^a   Endres, Kristina ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM10 ENDOPEPTIDASE; AMYLOID PRECURSOR PROTEIN; ETRETIN; ADAM PROTEIN; ADAM10 PROTEIN, HUMAN; APP PROTEIN, HUMAN; HYBRID PROTEIN; KERATOLYTIC AGENT; LUCIFERASE; MEMBRANE PROTEIN; SECRETASE;

ADAM10 GENE; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOASSAY; BLOOD BRAIN BARRIER; BRAIN CAPILLARY ENDOTHELIAL CELL; CELL MEMBRANE PERMEABILITY; COCULTURE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DRUG TARGETING; ELECTRIC RESISTANCE; GENETIC TRANSFECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; NEUROBLASTOMA CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; REPORTER GENE; SIGNAL TRANSDUCTION; SWINE; ANIMAL; BIOLOGICAL MODEL; BRAIN; CYTOLOGY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; ENDOTHELIUM CELL; GENE EXPRESSION; GENETICS; METABOLISM; NERVE CELL; PROMOTER REGION; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE; VASCULAR ENDOTHELIUM;

ACITRETIN; ADAM PROTEINS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BIOLOGICAL ASSAY; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CELL LINE, TUMOR; COCULTURE TECHNIQUES; DRUG DELIVERY SYSTEMS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; GENES, REPORTER; HUMANS; KERATOLYTIC AGENTS; LUCIFERASES; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; NEURONS; PROMOTER REGIONS, GENETIC; RECOMBINANT FUSION PROTEINS; SWINE;

EID: 84897405878     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091003     Document Type: Article

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