Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach

Journal of Medicinal Chemistry

Volumn 57, Issue 6, 2014, Pages 2799-2806

  Yin, Zhou ^a   Whittell, Louise R ^a   Wang, Yao ^a   Jergic, Slobodan ^a   Liu, Michael ^b   Harry, Elizabeth J ^b   Dixon, Nicholas E ^a   Beck, Jennifer L ^a   Kelso, Michael J ^a   Oakley, Aaron J ^a  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4 TETRAHYDROCARBAZOLE DERIVATIVE; DNA DIRECTED DNA POLYMERASE GAMMA;

ACINETOBACTER BAYLYI; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL GROWTH; DNA REPLICATION; DRUG SCREENING; DRUG TARGETING; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IC 50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; COMPUTATIONAL BIOLOGY; CRYSTALLOGRAPHY, X-RAY; DNA POLYMERASE III; DNA REPLICATION; DNA, BACTERIAL; DRUG DESIGN; ESCHERICHIA COLI; FLUORESCENCE POLARIZATION IMMUNOASSAY; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PEPTIDE FRAGMENTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84897404977     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500122r     Document Type: Article

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