Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H 4 receptor antagonists

Journal of Medicinal Chemistry

Volumn 57, Issue 6, 2014, Pages 2429-2439

  Savall, Brad M ^a   Chavez, Frank ^a   Tays, Kevin ^a   Dunford, Paul J ^a   Cowden, Jeffery M ^a   Hack, Michael D ^a   Wolin, Ronald L ^a   Thurmond, Robin L ^a   Edwards, James P ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINOPYRIMIDINE DERIVATIVE; HISTAMINE H4 RECEPTOR; HISTAMINE H4 RECEPTOR ANTAGONIST; INDOLE DERIVATIVE; JNJ 39758979; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ARTHRITIS; COLLAGEN; DOGS; DRUG DESIGN; DRUG DISCOVERY; HISTAMINE; HISTAMINE ANTAGONISTS; INDICATORS AND REAGENTS; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MODELS, MOLECULAR; PRURITUS; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84897386549     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401727m     Document Type: Article

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