Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and Cox-2 in a rat model

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Zhu, Xiaoyan ^a   Li, Qian ^a   Chang, Ruimin ^a   Yang, Dong ^b   Song, Zongbing ^a   Guo, Qulian ^a   Huang, Changsheng ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CURCUMIN; CYCLOOXYGENASE 2; HISTONE ACETYLTRANSFERASE PCAF; HISTONE H3; HISTONE H4; ANALGESIC AGENT; ENZYME INHIBITOR; HISTONE; LYSINE;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CHRONIC CONSTRICTION INJURY; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG DOSE COMPARISON; DRUG EFFICACY; ENZYME INHIBITION; ENZYME REGULATION; GENE EXPRESSION REGULATION; HISTONE ACETYLATION; HYPERALGESIA; MALE; MECHANICAL ALLODYNIA; NEUROPATHIC PAIN; NONHUMAN; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; RAT MODEL; SPINAL CORD; THERMAL HYPERALGESIA; TREATMENT DURATION; ACETYLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; GENETICS; METABOLISM; NEURALGIA; NOCICEPTION; PATHOPHYSIOLOGY; PROTEIN TRANSPORT; SPRAGUE DAWLEY RAT;

ACETYLATION; ANALGESICS; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CURCUMIN; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HISTONES; LYSINE; MALE; NEURALGIA; NOCICEPTION; P300-CBP TRANSCRIPTION FACTORS; PROMOTER REGIONS, GENETIC; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

EID: 84897381657     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091303     Document Type: Article

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