The Effect of Curcumin on Oxaliplatin and Cisplatin Neurotoxicity in Rats: Some Behavioral, Biochemical, and Histopathological Studies

Journal of Medical Toxicology

Volumn 9, Issue 1, 2013, Pages 25-33

  Al Moundhri, Mansour S ^a   Al Salam, Suhail ^b   Al Mahrouqee, Ahmed ^a   Beegam, S ^a   Ali, Badreldin H ^a  

^a SULTAN QABOOS UNIVERSITY   (Oman)

^b UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

Cisplatin; Curcumin; Neurotoxicity; Oxaliplatin; Rats

Indexed keywords

CISPLATIN; CURCUMIN; NEUROTENSIN; OXALIPLATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMYELINATION; DRUG EFFECT; HISTOPATHOLOGY; LOCOMOTION; MALE; MOTOR ACTIVITY; MOTOR COORDINATION; NEUROMUSCULAR FUNCTION; NEUROPROTECTION; NEUROTOXICITY; NOCICEPTION; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; SCIATIC NERVE INJURY; TAIL FLICK TEST;

EID: 84874278883     PISSN: 15569039     EISSN: 19376995     Source Type: Journal    
DOI: 10.1007/s13181-012-0239-x     Document Type: Article

References (39)

1. Saif MW, Reardon J (2005) Management of oxaliplatin-induced peripheral neuropathy. Ther Clin Risk Manag 1: 249-58.
2. Shah N, Dizon DS (2009) New-generation platinum agents for solid tumors. Future Oncol 5: 33-42.
3. Grothey A (2005) Clinical management of oxaliplatin-associated neurotoxicity. Clin Colorectal Cancer 5(Suppl 1): S38-46.
4. Broomand A, Jerremalm E, Yachnin J, Ehrsson H, Elinder F (2009) Oxaliplatin neurotoxicity-no general ion channel surface-charge effect. J Negat Results Biomed 8: 2.
5. Cavaletti G, Marmiroli P (2011) Chemotherapy-induced peripheral neurotoxicity. Nature Review Neurology 6: 657-666.
6. Holmes J, Stanko J, Varchenko M, Ding H, Madden VJ, Bagnell CR, Wyrick SD, Chaney SG (1998) Comparative neurotoxicity of oxaliplatin, cisplatin, and ormaplatin in a Wistar rat model. Toxicol Sci 46: 342-351.
7. Webster RG, Brain KL, Wilson RH, Grem JL, Vincent A (2005) Oxaliplatin induces hyperexcitability at motor and autonomic neuromuscular junctions through effects on voltage-gated sodium channels. Br J Pharmacol 146: 1027-1039.
8. Montagnani F, Turrisi G, Marinozzi C, Aliberti C, Fiorentini G (2011) Effectiveness and safety of oxaliplatin compared to cisplatin for advanced, unrespectable gastric cancer: a systematic review and meta-analysis. Gastric Cancer 14: 50-55.
9. Podratz JL, Knight AM, Ta LE, Staff NP, Gass JM, Genelin K, Schlattau A, Lathroum L, Windebank AJ (2011) Cisplatin induced mitochondrial DNA damage in dorsal root ganglion neurons. Neurobiol Dis 41: 661-668.
10. Shord SS, Bernard SA, Lindley C, Blodgett A, Mehta V, Churchel MA, Poole M, Pescatore SL, Luo FR, Chaney SG (2002) Oxaliplatin biotransformation and pharmacokinetics: a pilot study to determine the possible relationship to neurotoxicity. Anticancer Res 22: 2301-2309.
11. Carozzi VA, Marmiroli P, Cavaletti G (2010) The role of oxidative stress and anti-oxidant treatment in platinum-induced peripheral neurotoxicity. Curr Cancer Drug Targets 10: 670-682.
12. Mendonça LM, Dos Santos GC, Antonucci GA, Dos Santos AC, Bianchi ML, Antunes LM (2009) Evaluation of the cytotoxicity and genotoxicity of curcumin in PC12 cells. Mutat Res 675: 29-34.
13. Albers JW, Chaudhry V, Cavaletti G, Donehower RC (2011) Interventions for preventing neuropathy caused by cisplatin and related compounds. Cochrane Database Syst Rev 16: 2, CD005228.
14. Ali BH (2010) Amelioration of oxaliplatin neurotoxicity by drugs in humans and experimental animals: a minireview of recent literature. Basic Clin Pharmacol Toxicol 106: 272-279.
15. Durand JP, Deplanque G, Montheil V, Gornet JM, Scotte F, Mir O, Cessot A, Coriat R, Raymond E, Mitry E, Herait P, Yataghene Y, Goldwasser F (2011) Efficacy of venlafaxine for the prevention and relief of oxaliplatin-induced acute neurotoxicity: results of EFFOX, a randomized, double-blind, placebo-controlled phase III trial. Ann Oncol 23: 200-205.
16. Ali BH, Marrif H, Noureldyem SA, Bakhiet AO, Blunden G (2006) Some biological properties of curcumin. A review. Natural Product Communications 1: 509-521.
17. Jurenka JS (2009) Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev 14: 141-153.
18. Shanmugam MK, Kannaiyan R, Sethi G (2011) Targeting cell signaling and apoptotic pathways by dietary agents: role in the prevention and treatment of cancer. Nutr Cancer 63: 161-173.
19. Shehzad A, Ha T, Subhan F, Lee YS (2011) New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases. Eur J Nutr 50: 151-161.
20. Weissenberger J, Priester M, Bernreuther C, Rakel S, Glatzel M, Seifert V, Kögel D (2010) Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1, 2/STAT3 signaling pathway. Clin Cancer Res 16: 5781-5795.
21. Lapchak PA (2011) Neuroprotective and neurotrophic curcuminoids to treat stroke: a translational perspective. Expert Opin Investig Drugs 20: 13-22.
22. Ataie A, Sabetkasaei M, Haghparast A, Moghaddam AH, Kazeminejad B (2010) Neuroprotective effects of the polyphenolic antioxidant agent, curcumin, against homocysteine-induced cognitive impairment and oxidative stress in the rat. Pharmacol Biochem Behav 96: 378-385.
23. Guillemette A, Dansereau MA, Beaudet N, Richelson E, Sarret P. Intrathecal administration of NTS1 agonists reverses nociceptive behaviors in a rat model of neuropathic pain. Eur J Pain. 2012. In press.
24. Cavaletti G, Tredici G, Petruccioli MG, Dondè E, Tredici P, Marmiroli P, Minoia C, Ronchi A, Bayssas M, Etienne GG (2001) Effects of different schedules of oxaliplatin treatment on the peripheral nervous system of the rat. Eur J Cancer 37: 2457-2463.
25. Ali BH, Ziada A, Al Husseni I, Beegam S, Nemmar A (2011) Motor and behavioral changes in rats with adenine-induced chronic renal failure: influence of acacia gum treatment. Exp Biol Med (Maywood) 236: 107-112.
26. Pizziketti RJ, Pressman NS, Geller EB, Cowan A, Adler MW (1985) Rat cold water tail-flick: a novel analgesic test that distinguishes opioid agonists from mixed agonist-antagonists. Eur J Pharmacol 119: 23-29.
27. Ali BH, Al-Moundhri M, Tageldin M, Al Husseini IS, Mansour MA, Nemmar A, Tanira MO (2008) Ontogenic aspects of cisplatin-induced nephrotoxicity in rats. Food Chem Toxicol 46: 3355-3359.
28. Cavaletti G, Tredici G, Marmiroli P, Petruccioli MG, Barajon I, Fabbrica D (1992) Morphometric study of the sensory neuron and peripheral nerve changes induced by chronic cisplatin (DDP) administration in rats. Acta Neuropathol 84: 364-71.
29. Wongtawatchai T, Agthong S, Kaewsema A, Chentanez V (2009) Sex-related differences in cisplatin-induced neuropathy in rats. J Med Assoc Thai 92: 1485-1491.
30. Howells LM, Sale S, Sriramareddy SN, Irving GR, Jones DJ, Ottley CJ, Pearson DG, Mann CD, Manson MM, Berry DP, Gescher A, Steward WP, Brown K (2011) Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo. Int J Cancer 129: 476-486.
31. Cavaletti G, Alberti P, Frigeni B, Piatti M, Susani E (2011) Chemotherapy-induced neuropathy. Curr Treat Options Neurol 13: 180-190.
32. Aggarwal BB, Harikumar KB (2009) Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 41: 40-59.
33. Ali BH, Al-Wabel N, Mahmoud OM, Mousa HM, Hashad M (2005) Curcumin has a palliative action on gentamicin-induced nephrotoxicity in rats. Fundamental Clin Pharmacol 19: 473-477.
34. Waly M, Al-Moundhari M, Ali BH (2011) The effect of curcumin on cisplatin and oxaliplatin-induced oxidative stress in human embryonic kidneys (HEK) 293 cells. Renal Failure 33: 518-523.
35. Canta A, Chiorazzi A, Carozzi V, Meregalli C, Oggioni N, Sala B, Crippa L, Avezza F, Forestieri D, Rotella G, Zucchetti M, Cavaletti G (2011) In vivo comparative study of the cytotoxicity of a liposomal formulation of cisplatin (lipoplatin™). Cancer Chemother Pharmacol 68: 1001-1008.
36. Kumar P, Padi SS, Naidu PS, Kumar A (2007) Possible neuroprotective mechanisms of curcumin in attenuating 3-nitropropionic acid-induced neurotoxicity. Methods Find Exp Clin Pharmacol 29: 19-25.
37. Mustain WC, Rychahou PG, Evers BM (2011) The role of neurotensin in physiologic and pathologic processes. Curr Opin Endocrinol Diabetes Obes 18: 75-82.
38. Wachi M, Fujimaki M, Nakamura H, Inazuki G (1996) Effects of ethanol administration on brain neurotensin-like immunoreactivity in rats. Acta Neurol Scand 93: 211-214.
39. Antunes LM, Darin JD, Bianchi NL (2001) Effects of the antioxidants curcumin or selenium on cisplatin-induced nephrotoxicity and lipid peroxidation in rats. Pharmacol Res 43: 145-150.