Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury

Brain Research

Volumn 937, Issue 1-2, 2002, Pages 94-99

  Ma, Weiya ^a   Du, Wei ^a   Eisenach, James C ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Cyclooxygenase; Partial sciatic nerve ligation; Prostaglandin; Rat; Spinal cord

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; KETOROLAC; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PIROXICAM; PROSTAGLANDIN;

ALLODYNIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG SELECTIVITY; HYPERSENSITIVITY; NERVE LIGATION; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN FUNCTION; RAT; SCIATIC NERVE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HYPERALGESIA; ISOENZYMES; KETOROLAC; LIGATION; MECHANORECEPTORS; NERVE TISSUE PROTEINS; NITROBENZENES; PIROXICAM; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SCIATIC NERVE; SPINAL CORD; SULFONAMIDES;

EID: 0037165935     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)02593-3     Document Type: Article

References (29)

1. Direct activation of rat spinal dorsal horn neurons by prostaglandin E2
2. Quantitative assessment of tactile allodynia in the rat paw
3. Cyclooxygenase-1 is a marker for a subpopulation of putative nociceptive neurons in rat dorsal root ganglia
4. Small intrathecal doses of lysine-acetylsalicylate relieve intractable pain in man
5. 2 in a model of acute arthritis is accompanied by an up-regulation of cyclo-oxygenase-2 in the spinal cord
6. 2 and amino acids
7. 2-inhibitors in nerve-injured rats
8. Epidural nonsteroidal antiinflammatory drugs for cancer pain
9. Increased activation of nuclear factor kappa B in rat lumbar dorsal root ganglion neurons following partial sciatic nerve injuries
10. NS-398 treatment after trauma modifies NF-kappaB activation and improves survival
11. Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat
12. Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H, and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction
13. 2 and the effect of nitric oxide synthetase inhibition during strychnine-induced allodynia
14. 2 release after peripheral noxious stimulation
15. A stable prostacyclin analog enhances ectopic activity in rat sensory neurons following neuropathic injury
16. Intrathecal ketorolac tromethamine produces analgesia after chronic constriction injury of sciatic nerve in rat
17. Chronic refractory pain in cancer patients: Value of the spinal injection of lysine acetylsalicylate
18. Spontaneous and evoked release of prostaglandins from frog spinal cord
19. Continuous subcutaneous infusion of ketorolac in cancer neuropathic pain unresponsive to opioid and adjuvant drugs. A case report
20. Persistent accumulation of cyclooxygenase-1 (COX-1) expressing microglia/macrophages and upregulation by endothelium following spinal cord injury
21. Effects of sympathectomy in a model of causalgiform pain produced by partial sciatic nerve injury in rats
22. Pharmacological analysis of cyclooxygenase-1 in inflammation
23. Intrathecal NSAIDS attenuate inflammation-induced neuropeptide release from rat spinal cord slices
24. Hyperalgesia due to nerve injury: Role of prostaglandins
25. Non-steroidal drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis
26. Spinal cord glia: New players in pain
27. Prostanoids synthesized by cyclo-oxygenase isoforms in rat spinal cord and their contribution to the development of neuronal hyperexcitability
28. Chronic catheterization of the spinal subarachnoid space
29. 2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1