Assessment of the reproductive toxicity of inhalation exposure to ethyl tertiary butyl ether in male mice with normal, low active and inactive ALDH2

Archives of Toxicology

Volumn 88, Issue 4, 2014, Pages 1007-1021

  Weng, Zuquan ^a,d   Ohtani, Katsumi ^a   Suda, Megumi ^a   Yanagiba, Yukie ^a   Kawamoto, Toshihiro ^b   Nakajima, Tamie ^c   Wang, Rui Sheng ^a  

^a NATIONAL INSTITUTE OF OCCUPATIONAL SAFETY AND HEALTH   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c CHUBU UNIVERSITY   (Japan)

^d NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Aldh2 knockout mice; Ethyl tertiary butyl ether; Inhalation exposure; Reproductive toxicity

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; ETHER DERIVATIVE; ETHYL TERTIARY BUTY LETHER; UNCLASSIFIED DRUG; 8-OXO-7-HYDRODEOXYGUANOSINE; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 2, MOUSE; BIOLOGICAL MARKER; DEOXYGUANOSINE; ETHYL TERT-BUTYL ETHER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; DNA STRAND BREAKAGE; EPIDIDYMIS; FEMALE; HISTOPATHOLOGY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTIS WEIGHT; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; BIOTRANSFORMATION; C57BL MOUSE; COMET ASSAY; DEFICIENCY; DOSE RESPONSE; DRUG EFFECTS; EXPOSURE; FERTILITY; GENETICS; KNOCKOUT MOUSE; METABOLISM; ORGAN SIZE; PATHOLOGY; RISK ASSESSMENT; SPERMATOZOON; TESTIS; TIME FACTOR;

MUS;

ALDEHYDE DEHYDROGENASE; ANIMALS; BIOMARKERS; BIOTRANSFORMATION; COMET ASSAY; DEOXYGUANOSINE; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYL ETHERS; FERTILITY; INHALATION EXPOSURE; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGAN SIZE; RISK ASSESSMENT; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; TESTIS; TIME FACTORS;

EID: 84897112721     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1192-z     Document Type: Article

References (44)

1. Aitken J, Fisher H (1994) Reactive oxygen species generation and human spermatozoa: the balance of benefit and risk. BioEssays 16:259-267 (Pubitemid 2073508)
2. Aitken RJ, Krausz C (2001) Oxidative stress, DNA damage and the Y chromosome. Reproduction 122:497-506 (Pubitemid 32975956)
3. Aitken RJ, Baker MA, Sawyer D (2003) Oxidative stress in the male germ line and its role in the aetiology of male infertility and genetic disease. Reprod Biomed Online 7:65-70 (Pubitemid 36874408)
4. Aitken RJ, Koopman P, Lewis SE (2004) Seeds of concern. Nature 432:48-52 (Pubitemid 39490823)
5. Bevan C, Tyl RW, Neeper-Bradley TL, Fisher LC, Panson RD, Douglas JF, Andrews LS (1997) Developmental toxicity evaluation of methyl tertiary-butyl ether (MTBE) by inhalation in mice and rabbits. J Appl Toxicol 17(Suppl 1):S21-S29 (Pubitemid 127781291)
6. Brennan P, Lewis S, Hashibe M, Bell DA, Boffetta P, Bouchardy C, Caporaso N, Chen C, Coutelle C, Diehl SR, Hayes RB, Olshan AF, Schwartz SM, Sturgis EM, Wei Q, Zavras AI, Benhamou S (2004) Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review. Am J Epidemiol 159:1-16 (Pubitemid 38049416)
7. Conaway C, Schroeder RE, Snyder NK (1985) Teratology evaluation of methyl tertiary butyl ether in rats and mice. J Toxicol Environ Health 16:797-809 (Pubitemid 16131168)
8. Cooke MS, Evans MD, Dizdaroglu M, Lunec J (2003) Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J 17:1195-1214 (Pubitemid 36775767)
9. de Peyster A (2010) Ethyl t-butyl ether: review of reproductive and developmental toxicity. Birth Defects Res B Dev Reprod Toxicol 89:239-263
10. de Peyster A, Stanard B, Westover C (2009) Effect of ETBE on reproductive steroids in male rats and rat Leydig cell cultures. Toxicol Lett 190:74-80
11. Donnelly ET, McClure N, Lewis SE (1999) The effect of ascorbate and alpha-tocopherol supplementation in vitro on DNA integrity and hydrogen peroxide-induced DNA damage in human spermatozoa. Mutagenesis 14:505-512
12. Faulkner TP, Wiechart JD, Hartman DM, Hussain AS (1989) The effects of prenatal tertiary butanol administration in CBA/J and C57BL/6 J mice. Life Sci 45:1989-1995 (Pubitemid 19277493)
13. Gaoua W (2003) Ethyl tertiary butyl ether (ETBE), CAS No. 637-92-3: Reproduction/developmental toxicity dose-range finding/probe study by the oral (gavage) route in two strains of rat. CIT Study No. 24168 RSR. Unpublished study for Totalfinaelf on behalf of the ETBE Producers' Consortium
14. Genesca A, Caballin MR, Miro R, Benet J, Germa JR, Egozcue J (1992) Repair of human sperm chromosome aberrations in the hamster egg. Hum Genet 89:181-186
15. Hagiwara A, Doi Y, Imai N, Nakashima H, Ono T, Kawabe M, Furukawa F, Tamano S, Nagano K, Fukushima S (2011) Medium-term multi-organ carcinogenesis bioassay of ethyl tertiary-butyl ether in rats. Toxicology 289:160-166
16. Kitagawa K, Kawamoto T, Kunugita N, Tsukiyama T, Okamoto K, Yoshida A, Nakayama K (2000) Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett 476:306-311 (Pubitemid 30410837)
17. Latendresse JR, Warbrittion AR, Jonassen H, Creasy DM (2002) Fixation of testes and eyes using a modified Davidson's fluid: comparison with Bouin's fluid and conventional Davidson's fluid. Toxicol Pathol 30:524-533
18. Le Gal A, Dreano Y, Gervasi PG, Berthou F (2001) Human cytochrome P450 2A6 is the major enzyme involved in the metabolism of three alkoxyethers used as oxyfuels. Toxicol Lett 124:47-58 (Pubitemid 33000348)
19. Lewis SE (2007) Is sperm evaluation useful in predicting human fertility? Reproduction 134:31-40
20. Lewis SE, Agbaje IM (2008) Using the alkaline comet assay in prognostic tests for male infertility and assisted reproductive technology outcomes. Mutagenesis 23:163-170
21. Lewis SE, Agbaje I, Alvarez J (2008) Sperm DNA tests as useful adjuncts to semen analysis. Syst Biol Reprod Med 54:111-125
22. Li Q, Kobayashi M, Inagaki H, Hirata Y, Hirata K, Shimizu T, Wang RS, Suda M, Kawamoto T, Nakajima T, Kawada T (2011) Effects of subchronic inhalation exposure to ethyl tertiary butyl ether on splenocytes in mice. Int J Immunopathol Pharmacol 24:837-847
23. McGregor D (2010) Tertiary-butanol: a toxicological review. Crit Rev Toxicol 40:697-727
24. Meamar M, Zribi N, Cambi M, Tamburrino L, Marchiani S, Filimberti E, Fino MG, Biggeri A, Menezo Y, Forti G, Baldi E, Muratori M (2012) Sperm DNA fragmentation induced by cryopreservation: new insights and effect of a natural extract from Opuntia ficus-indica. Fertil Steril 98:326-333
25. Medinsky MA, Wolf DC, Cattley RC, Wong B, Janszen DB, Farris GM, Wright GA, Bond JA (1999) Effects of a thirteen-week inhalation exposure to ethyl tertiary butyl ether on fischer-344 rats and CD-1 mice. Toxicol Sci 51:108-118 (Pubitemid 29439235)
26. Niemela O, Parkkila S, Bradford B, Iimuro Y, Pasanen M, Thurman RG (2002) Effect of Kupffer cell inactivation on ethanol-induced protein adducts in the liver. Free Radic Biol Med 33:350-355 (Pubitemid 34786273)
27. Novitskiy G, Traore K, Wang L, Trush MA, Mezey E (2006) Effects of ethanol and acetaldehyde on reactive oxygen species production in rat hepatic stellate cells. Alcohol Clin Exp Res 30:1429-1435 (Pubitemid 44114695)
28. O'Brien PJ, Siraki AG, Shangari N (2005) Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health. Crit Rev Toxicol 35:609-662
29. Ollero M, Gil-Guzman E, Lopez MC, Sharma RK, Agarwal A, Larson K, Evenson D, Thomas AJ Jr, Alvarez JG (2001) Characterization of subsets of human spermatozoa at different stages of maturation: implications in the diagnosis and treatment of male infertility. Hum Reprod 16:1912-1921 (Pubitemid 32916222)
30. Saito A, Sasaki T, Kasai T, Katagiri T, Nishizawa T, Noguchi T, Aiso S, Nagano K, Fukushima S (2013) Hepatotumorigenicity of ethyl tertiary-butyl ether with 2-year inhalation exposure in F344 rats. Arch Toxicol 87:905-914
31. Secretan B, Straif K, Baan R, Grosse Y, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Freeman C, Galichet L, Cogliano V (2009) A review of human carcinogens - part E: tobacco, areca nut, alcohol, coal smoke, and salted fish. Lancet Oncol 10:1033-1034
32. Seitz HK, Stickel F (2007) Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer 7:599-612 (Pubitemid 47106631)
33. Sgambato A, Iavicoli I, De Paola B, Bianchino G, Boninsegna A, Bergamaschi A, Pietroiusti A, Cittadini A (2009) Differential toxic effects of methyl tertiary butyl ether and tert-butanol on rat fibroblasts in vitro. Toxicol Ind Health 25:141-151
34. Simon L, Brunborg G, Stevenson M, Lutton D, McManus J, Lewis SE (2010) Clinical significance of sperm DNA damage in assisted reproduction outcome. Hum Reprod 25:1594-1608
35. Simon L, Lutton D, McManus J, Lewis SE (2011) Sperm DNA damage measured by the alkaline Comet assay as an independent predictor of male infertility and in vitro fertilization success. Fertil Steril 95:652-657
36. Smith C, O'Donovan MR, Martin EA (2006) hOG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII. Mutagenesis 21:185-190 (Pubitemid 43882069)
37. Stanard B, Westover C, Hirakawa B, Gonzalez J, and de Peyster A (2003) Effect of ethyl t-butyl ether (ETBE) on testosterone in male rats. Toxicologist 72:S1, Abstract 644. Toxicologist
38. Thomson LK, Fleming SD, Aitken RJ, De Iuliis GN, Zieschang JA, Clark AM (2009) Cryopreservation-induced human sperm DNA damage is predominantly mediated by oxidative stress rather than apoptosis. Hum Reprod 24:2061-2070
39. Wang M, McIntee EJ, Cheng G, Shi Y, Villalta PW, Hecht SS (2000) Identification of DNA adducts of acetaldehyde. Chem Res Toxicol 13:1149-1157
40. Weng Z, Suda M, Ohtani K, Mei N, Kawamoto T, Nakajima T, Wang RS (2011) Aldh2 knockout mice were more sensitive to DNA damage in leukocytes due to ethyl tertiary butyl ether exposure. Ind Health 49:396-399
41. Weng Z, Suda M, Ohtani K, Mei N, Kawamoto T, Nakajima T, Wang RS (2012) Differential genotoxic effects of subchronic exposure to ethyl tertiary butyl ether in the livers of Aldh2 knockout and wild-type mice. Arch Toxicol 86:675-682
42. Weng Z, Suda M, Ohtani K, Mei N, Kawamoto T, Nakajima T, Wang RS (2013) Subchronic exposure to ethyl tertiary butyl ether resulting in genetic damage in Aldh2 knockout mice. Toxicology 311:107-114
43. Yamaki K, Yoshino S (2009) Inhibition of IgE-induced mast cell activation by ethyl tertiary-butyl ether, a bioethanol-derived fuel oxygenate. J Pharm Pharmacol 61:1243-1248
44. Yuan Y, Wang HF, Sun HF, Du HF, Xu LH, Liu YF, Ding XF, Fu DP, Liu KX (2007) Adduction of DNA with MTBE and TBA in mice studied by accelerator mass spectrometry. Environ Toxicol 22:630-635 (Pubitemid 350105975)