Ethyl t-butyl ether: Review of reproductive and developmental toxicity

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 89, Issue 3, 2010, Pages 239-263

  De Peyster, Ann ^a  

^a SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

DART studies; Ethyl t butyl ether; Fuel oxygenates; Reproductive and developmental toxicity

Indexed keywords

ETHER DERIVATIVE; TERT BUTYL ALCOHOL; TERT BUTYL ETHYL ETHER; TERT BUTYL METHYL ETHER; UNCLASSIFIED DRUG; ETHYL TERT-BUTYL ETHER;

BIRTH; DATA BASE; DRUG ADMINISTRATION ROUTE; EMBRYO DEVELOPMENT; FERTILITY; FETUS DEVELOPMENT; HISTOLOGY; INHALATION TEST; NONHUMAN; ORGAN WEIGHT; POSTNATAL DEVELOPMENT; PRACTICE GUIDELINE; PRENATAL DEVELOPMENT; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROGENY; RABBIT; RAT; REPRODUCTIVE TOXICITY; REVIEW; SEMEN ANALYSIS; STEROIDOGENESIS; TOXICOLOGY; ANIMAL; DRUG EFFECTS; FEMALE; FETUS; REPRODUCTION; TOXICITY;

ORYCTOLAGUS CUNICULUS; RATTUS; RODENTIA;

ANIMALS; EMBRYONIC DEVELOPMENT; ETHYL ETHERS; FEMALE; FETUS; METHYL ETHERS; REPRODUCTION; TERT-BUTYL ALCOHOL;

EID: 77953554199     PISSN: 15429733     EISSN: 15429741     Source Type: Journal    
DOI: 10.1002/bdrb.20246     Document Type: Review

References (61)

1. Agency for Toxic Substances and Disease Registry (ATSDR). 1996. Toxicological profile for methyl-t-butyl ether. http://www.atsdr.cdc. gov/toxprofiles/tp91.html
2. Anderson FA. 2005. Amended final report of the safety assessment of t-butyl alcohol used in cosmetics. Int J Toxicol 24(Suppl 2):1-20.
3. Berger T, Horner CM. 2003. In vivo exposure of female rats to toxicants may affect oocyte quality. Reprod Toxicol 17:273-281 (erratum appears in Reprod Toxicol 2004 18:447).
4. Bevan C, Tyl RW, Neeper-Bradley L, Fisher LC, Panson RD, Douglas JF, Andrews LS. 1997a. Developmental toxicity evaluation of methyl tertiary-butyl ether (MTBE) by inhalation in mice and rabbits. J Appl Toxicol 17(Suppl 1):S21-S29. (Pubitemid 127781291)
5. Bevan C, Neeper-Bradley L, Tyl RW, Fisher LC, Panson RD, Kneiss JJ, Andrews LS. 1997b. Two-generation reproductive toxicity study of methyl tertiary-butyl ether (MTBE) in rats. J Appl Toxicol 17(Suppl 1):S13-S19.
6. Biles RW, Schroeder RE, Holdsworth CE. 1987. Methyl tertiary butyl ether inhalation in rats: A single generation reproduction study. Toxicol Ind Health 3:519-533.
7. Boorman GA, Eustis SL, Elwell MR, Montgomery C. 1990. Pathology of the Fischer rat. New York: Academic Press.
8. BRRC (Bushy Run Research Center). 1989a. Developmental toxicity study of inhaled methyl tertiary butyl ether in CD-1 mice. Project Report 52-526. Bushy Run Research Center, Export, PA.
9. BRRC (Bushy Run Research Center). 1989b. Developmental toxicity study of inhaled methyl tertiary butyl ether in New Zealand white rabbits. Project Report 51-268. Bushy Run Research Center, Export, PA.
10. BRRC (Bushy Run Research Center). 1991. Two-generation reproduction study of inhaled methyl tert-butyl ether in CD (Sprague-Dawley) rats. Project ID 53-594. Bushy Run Research Center, Export, PA.
11. Chernoff N, Rogers JM, Turner CI, Francis BM. 1991. Significance of supernumerary ribs in rodent developmental toxicity studies: postnatal persistence in mice and rats. Fundam Appl Toxicol 17:448-453.
12. CIIT (Chemical Industry Institute of Toxicology). 1996a. Ethyl tertiary butyl ether (ETBE): ninety-day vapor inhalation toxicity study in Fischer 344 rats. Chemical Industry Institute of Toxicology final report 95029 for ARCO Chemical Company, PA, Research Triangle Park, NC.
13. CIIT (Chemical Industry Institute of Toxicology). 1996b. Ethyl tertiary butyl ether (ETBE): ninety-day vapor inhalation toxicity study in CD-1 mice. Chemical Industry Institute of Toxicology final report 95030 for ARCO Chemical Company, PA, Research Triangle Park, NC.
14. CIT (Centre International de Toxicologie). 2003. Ethyl tertiary butyl ether (ETBE), CAS No. 637-92-3: Reproduction/developmental toxicity dose-range finding/probe study by the oral (gavage) route in two strains of rat. CIT Study No. 24168 RSR. Unpublished study for Totalfinaelf on behalf of the ETBE Producers' Consortium, Evreux, France.
15. CIT (Centre International de Toxicologie). 2004a. Ethyl tertiary butyl ether (ETBE): Two-generation study (reproduction and fertility effects) by the oral route (gavage) in rats. CIT Study No. 24859 RSR. Unpublished study for Totalfinaelf on behalf of the ETBE Producers' Consortium, Evreux, France.
16. CIT (Centre International de Toxicologie). 2004b. Ethyl tertiary butyl ether (ETBE): Prenatal developmental toxicity study by the oral route (gavage) in rats. CIT Study No. 24860 RSR. Unpublished study for Totalfinaelf on behalf of the ETBE Producers' Consortium, Evreux, France.
17. Conaway CC, Schroeder RE, Snyder NK. 1985. Teratology evaluation of methyl tertiary butyl ether in rats and mice. J Toxicol Environ Health 16:797-809.
18. Creasy DM. 2003. Evaluation of testicular toxicology: A synopsis and discussion of the recommendations proposed by the Society of Toxicologic Pathology. Birth Defects Res (B) 68:408-415.
19. Cruzan G, Borghoff SJ, de Peyster A, Hard GC, McClain M, McGregor DB, Thomas MG. 2007. Methyl tertiary-butyl ether mode of action for cancer endpoints in rodents. Reg Toxicol Pharmacol 47:156-165.
20. Dang ZC, Rorije E, Esch TH, Muller A, Hakkert BC, Piersma AH. 2009. Retrospective analysis of relative parameter sensitivity in multi-generation reproductive toxicity studies. Reprod Toxicol 28:196-202.
21. Daniel MA, Evans MA. 1982. Quantitative comparison of maternal ethanol and maternal tertiary butanol diet on postnatal development. J Pharmacol Exp Ther 222:294-300.
22. de Peyster A, MacLean KJ, Stephens BA, Ahern LD, Westover CM, Rozenshteyn D. 2003. Subchronic studies in Sprague-Dawley rats to investigate mechanisms of MTBE-induced Leydig cell cancer. Toxicol Sci 72:31-42.
23. de Peyster A, Stanard B, Westover C. 2009. Effects of ETBE on reproductive steroids in male rats and rat Leydig cell cultures. Toxicol Lett 190:74-80.
24. European Fuel Oxygenates Association (EFOA 2010), www.efoa.org. Accessed 1/13/10.
25. Faulkner TP, Wiethert JD, Harman DM, Hussain AS. 1989. The effects of prenatal tertiary butanol administration in CBA/J and C57BL/6J mice. Life Sci 45:1989-1995.
26. Foulon O, Jaussely C, Repetto M, Urtizberea M, Blacker AM. 2000. Postnatal evolution of supernumerary ribs in rats after a single administration of sodium salicylate. J Appl Toxicol 20:205-209.
27. Francis EZ, Kimmel GL 1988. Proceedings of the workshop on one- vs. two-generation reproductive effects studies. J Am Coll Toxicol 7: 911-925.
28. Grant KA, Samson HH. 1982. Ethanol and tertiary butanol induced microcephaly in the neonatal rat: Comparison of brain growth parameters. Neurobehav Toxicol Teratol 4:315-321.
29. Harris SB, DeSesso JM. 1994. Practical guidance for evaluating and interpreting developmental toxicity tests. J Hazard Materials 39: 245-266.
30. Hess RA, Moore BJ. 1993. Histological methods for evaluation of the testis. In: Methods in toxicology, vol. 3A: male reproductive toxicology. Chapin RE, Heindel JJ, Tyson CA, Witschi HR, editors. New York: Academic Press. p. 52-85.
31. Hood RD, Miller DB. 2006. Maternally mediated effects on development. In: Hood RD, editor. Developmental and reproductive toxicology, a practical approach, 2nd ed. Boca Raton: Taylor and Francis.
32. Huntingdon Life Sciences (HLS). 2004. TBA: Reproduction/developmental toxicity screening in rats; Study Number 03-4254. Princeton, NJ: Huntingdon Life Sciences.
33. IIT Research Institute (Illinois Institute of Technology Research Institute). 1991. Four-week inhalation toxicity study of ethyl tert-butyl ether (ETBE) in rats. IIT Research Institute, Life Sciences research under contract to Amoco Corporation, Chicago, IL; Study No. 1544. Unpublished report.
34. Janer G, Hakkert BC, Slob W, Vermeire T, Piersma AH. 2007. A retrospective analysis of the two-generation study: What is the added value of the second generation? Reprod Toxicol 24:97-102.
35. Li D, Yuan C, Gong Y, Huang Y, Han X. 2008. The effects of methyl-t-butyl ether (MTBE) on the male rat reproductive system. Food Chem Toxicol 46:2402-2408.
36. MARTA. 2004. Historical control database of preclinical developmental teratology and reproductive toxicity parameters. A joint project of MARTA and MTA: www.hcd.org.
37. Marty MS, Allen B, Chapin RE, Cooper R, Daston GP, Flaws JA, Foster PMD, Makris SL, Mylchreest E, Sandler D, Tyl RW. 2009. Inter-laboratory control data for reproductive endpoints required in the OPPTS 870.3800/OECD 416 reproduction and fertility test. Birth Defects Res (Part B) 86:470-489.
38. McGregor D. 2006. Methyl-tertiary-butyl ether: Studies for potential human health hazards. Crit Rev Toxicol 36:319-358.
39. McGregor D. 2007. Ethyl tertiary-butyl ether: A toxicological review. Crit Rev Toxicol 37:287-312.
40. Medinsky MA, Wolf DC, Cattley RC, Wong B, Janszen DB, Farris GM, Wright GA, Bond JA. 1999. Effects of a thirteen-week inhalation exposure to ethyl tertiary butyl ether on Fischer-344 rats and CD-1 mice. Toxicol Sci 51:108-118 (erratum appears in Toxicol Sci 2006 94:441).
41. METI (Ministry of Economy, Trade and Industry). 2008a. Single generation oral toxicity study in rats. In: Risk Assessment of Ethyl Tertiary Butyl Ether (ETBE). Full report in Japanese can be accessed through the Japan Petroleum Energy Center website.
42. METI (Ministry of Economy, Trade and Industry). 2008b. Prenatal developmental toxicity test in rats In: Risk Assessment of Ethyl Tertiary Butyl Ether (ETBE). Full report in Japanese can be accessed through the Japan Petroleum Energy Center website.
43. METI (Ministry of Economy, Trade and Industry). 2008c. Preliminary prenatal developmental toxicity test in rabbits. In: Risk Assessment of Ethyl Tertiary Butyl Ether (ETBE). Full report in Japanese can be accessed through the Japan Petroleum Energy Center website.
44. METI (Ministry of Economy, Trade and Industry). 2008d. Final prenatal developmental toxicity test in rabbits. In: Risk Assessment of Ethyl Tertiary Butyl Ether (ETBE). Full report in Japanese can be accessed through the Japan Petroleum Energy Center website.
45. METI (Ministry of Economy, Trade and Industry). 2008e. 90-day repeated inhalation toxicity test in rats. In: Risk Assessment of Ethyl Tertiary Butyl Ether (ETBE). Full report in Japanese can be accessed through the Japan Petroleum Energy Center website.
46. METI (Ministry of Economy, Trade and Industry). 2008f. 180-day repeated oral toxicity test in rats. In: Risk Assessment of Ethyl Tertiary Butyl Ether (ETBE). Full report in Japanese can be accessed through the Japan Petroleum Energy Center website.
47. METI (Ministry of Economy, Trade and Industry). 2008g. Comparison of two generation reproductive toxicity study and one generation reproductive toxicity study on ETBE. Section 2.1.3.2 3. in: Risk Assessment of Ethyl Tertiary Butyl Ether (ETBE). Full report in Japanese can be accessed through the Japan Petroleum Energy Center website.
48. METI (Ministry of Economy, Trade and Industry). 2009. The Executive Summary: Risk Assessment of Ethyl Tertiary Butyl Ether (ETBE) and Outline of the "Executive Summary" by JPEC (Japan Petroleum Energy Center). October 16, 2009.
49. Moser GJ, Wong BA, Wolf DC, Moss OR, Goldsworthy TL. 1996. Comparative short-term effects of methyl tertiary butyl ether and unleaded gasoline vapor in female B6C3F1 mice. Fundam Appl Toxicol 31:173-183.
50. Moser GJ, Wolf DC, Sar M, Gaido KW, Janszen D, Goldsworthy TL. 1998. Methyl tertiary butyl ether-induced endocrine alterations in mice are not mediated through the estrogen receptor. Toxicol Sci 41:77-87.
51. Nelson BK, Brightwell WS, Khan A, Burg JR, Goad PT. 1989. Lack of selective developmental toxicity of three butanol isomers administered by inhalation to rats. Fundam Appl Toxicol 12:469-479.
52. Nelson BK, Brightwell WS, Khan A, Shaw PB, Krieg EV, Massari VJ. 1991. Behavioral teratology investigation of tertiary-butanol administered by inhalation to rats. Pharmacopsychoecologia 4:1-7.
53. NTP (National Toxicology Program). 1995. Toxicology and carcinogenesis studies of t-butyl alcohol in F344/N rats and B6C3F1 mice (drinking water studies). Tech. Rep. Ser. No. 436; NIH Publ. No. 95-3167. Research Triangle Park, NC: NTP.
54. NTP (National Toxicology Program). 1997. NTP technical report on toxicity studies of t-butyl alcohol (CAS no. 75-65-0) administered by inhalation to F344/N rats and B6C3F1 mice. Technical Report Series no. 53, NIH Publ. No. 97-3942). Research Triangle Park, NC: NTP.
55. Rudén C, Hansson SO. 2008. Comment on: "A retrospective analysis of the two-generation study: What is the added value of the second generation?" (Letter to the Editor) Reprod Toxicol 25: 397-405.
56. Tyl RW, Marr MC. 2006. Developmental toxicity testing: methodology. In: Hood RD, editor. Developmental and reproductive toxicology, a practical approach, 2nd ed. Boca Raton, FL: Taylor and Francis. p. 201-261.
57. UBTL, Inc. (Utah Biomedical Testing Laboratory). 1994. Twenty-eight (28) day dermal toxicity study in rats administered test article F-266. UBTL, Inc. under contract to ARCO, Salt Lake City, UT; UBTL Study No. 66894. Unpublished report.
58. Vetrano KM. 1993. Final report to ARCO Chemical Company on the odor and taste threshold studies performed with MTBE and ETBE. TRC Environmental Corporation under contract to ARCO, Windsor, CT; Project No. 14332-M31. Unpublished report.
59. White RD, Daughtrey WC, Wells MS. 1995. Health effects of inhaled tertiary amyl methyl ether and ethyl tertiary butyl ether. Toxicol Lett 82:719-724.
60. Williams T, Cattley R., Borghoff S. 2000. Alterations in endocrine responses in male Sprague-Dawley rats following oral administration of methyl tert-butyl ether. Toxicol Sci 54:168-176. (Pubitemid 30152467)
61. Zhang YP, Macina OR, Roenkranz H, Karon MH, Mattison DR, Klopman G. 1997. Prediction of the metabolism and toxicological profiles of gasoline oxygenates. Inhal Toxicol 9:237-254. (Pubitemid 27195504)