Inhibition of IgE-induced mast cell activation by ethyl tertiary-butyl ether, a bioethanol-derived fuel oxygenate

Journal of Pharmacy and Pharmacology

Volumn 61, Issue 9, 2009, Pages 1243-1248

  Yamaki, Kouya ^a   Yoshino, Shin ^a  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Degranulation; Ethyl tertiary butyl ether; IgE; Mast cell; Phosphatidylinositol 3 kinase; RBL2H3

Indexed keywords

ALCOHOL; BETA N ACETYLHEXOSAMINIDASE; BIOLOGICAL MARKER; CALCIUM; ETHER DERIVATIVE; ETHYL TERT BUTYL ETHER; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; OVALBUMIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TERT BUTYL ALCOHOL; TYROSINE; UNCLASSIFIED DRUG; ETHYL TERT-BUTYL ETHER; FOSSIL FUEL;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL ACTIVATION; CELL FUNCTION; CELL LINE; CONTROLLED STUDY; CROSS LINKING; CYTOTOXICITY; DESENSITIZATION; ENZYME RELEASE; GROWTH INHIBITION; MAST CELL; MAST CELL DEGRANULATION; MEDIATOR; NONHUMAN; PROTEIN PHOSPHORYLATION; ANIMAL; CELL SURVIVAL; DEGRANULATION; DRUG EFFECT; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; RAT;

ANIMALS; CALCIUM; CELL DEGRANULATION; CELL LINE; CELL SURVIVAL; ETHANOL; ETHYL ETHERS; FOSSIL FUELS; IMMUNOGLOBULIN E; MAST CELLS; OVALBUMIN; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; TERT-BUTYL ALCOHOL; TYROSINE;

EID: 85047682629     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.61.09.0015     Document Type: Article

References (24)

1. McGregor D. Ethyl tertiary-butyl ether: a toxicological review. Crit Rev Toxicol 2007; 37: 287-312.
2. Medinsky MA et al. Effects of a thirteen-week inhalation exposure to ethyl tertiary butyl ether on Fischer-344 rats and CD-1 mice. Toxicol Sci 1999; 51: 108-118.
3. Prescott-Matthews JS et al. Methyl tert-butyl ether causes α2u-globulin nephropathy and enhanced renal cells proliferation in male Fischer-344 rats. Toxicol Appl Pharmacol 1997; 143: 301-314.
4. Nihlen A et al. Controlled ethyl tert-butyl ether (ETBE) exposure of male volunteers. (ii) Acute effects. Toxicol Sci 1998; 46: 143-150.
5. McGregor D. Methyl tertiary-butyl ether: studies for potential human health hazards. Crit Rev Toxicol 2006; 36: 821-835.
6. Peng Z, Beaven MA. An essential role for phospholipase D in the activation of protein kinase C and degranulation in mast cells. J Immunol 2005; 174: 5201-5208.
7. 2 pathway in a rat mast cell line. J Immunol 1995; 154: 5391-5402.
8. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63.
9. Kao JP et al. Photochemically generated cytosolic calcium pulses and their detection by fluo-3. J Biol Chem 1989; 264: 8179-8184.
10. Iavicoli I et al. Methyl-tertiary-butyl ether (MTBE) inhibits growth and induces cell transformation in rodent fibroblasts. Anticancer Res 2002; 22: 2173-2177.
11. Zhang J et al. Phosphorylation of Tyr342 in the linker region of Syk is critical for FcεRI signaling in mast cells. Mol Cell Biol 2002; 22: 8144-8154.
12. 2+ entrymechanism.J Biol Chem 2001; 276: 14814-14820.
13. Lin P et al. Activation of phospholipase D in a rat mast (RBL 2H3) cell line: a possible unifying mechanism for IgE-dependent degranulation and arachidonic acid metabolite release. J Immunol 1991; 146: 1609-1616.
14. 2, C, and D activity in RBL cells stimulated through FcεR1 is due to spreading and not simply adhesion. J Cell Sci 1998; 110: 771-780.
15. Beaven MA et al. The calcium signal and phosphatidylinositol breakdown in 2H3 cells. J Biol Chem 1984; 259: 7137-7142.
16. Dippel E et al. A heterotrimeric G protein complex couples the muscarinic m1 receptor to phospholipase C-β. Proc Natl Acad Sci USA 1996; 93: 1391-1396.
17. Santini F, Beaven MA. Tyrosine phosphorylation of a mitogen-activated protein kinase-like protein occurs at a late step in exocytosis: studies with tyrosine phosphatase inhibitors and various secretagogues in rat RBL-2H3 cells. J Biol Chem 1993; 268: 22716-22722.
18. 2+ transients. Anesthesiology 2000; 92: 1746-1756.
19. Minami K et al. The inhibitory effects of anesthetics and ethanol on substance P receptors expressed in Xenopus oocytes. Anesth Analg 2002; 94: 79-83.
20. Moriya K et al. ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fcε receptor I-mediated activation of Syk. Proc Natl Acad Sci 1997; 94: 12539-12544.
21. Yu M et al. Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcεRI. J Immunol 2006; 176: 2421-2429.
22. Parravicini V et al. Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat Immunol 2002; 3: 741-748.
23. Durieux ME. Halothane inhibits signaling through m1 muscarinic receptors expressed in Xenopus oocyte. Anesthesiology 1995; 82: 174-182.
24. Choi OH et al. Antigen and carbachol mobilize calcium by similar mechanisms in a transfected mast cell line (RBL-2H3 cells) that expresses M1 muscarinic receptors. J Immunol 1993; 151: 5586-5595.