Bench and mathematical modeling of the effects of breathing a helium/oxygen mixture on expiratory time constants in the presence of heterogeneous airway obstructions

BioMedical Engineering Online

Volumn 11, Issue , 2012, Pages

  Martin, Andrew R ^a   Katz, Ira M ^b,c   Terzibachi, Karine ^b   Gouinaud, Laure ^b   Caillibotte, Georges ^b   Texereau, Joëlle ^b  

^a Delaware Research and Technology Center   (United States)

^b Medical Gases Group   (France)

^c LAFAYETTE COLLEGE   (United States)

Author keywords

Airway resistance; Exhalation; Gas trapping; Heliox; Helium; Hyperinflation; Lung; Mechanical ventilation; Time constant; Ventilation distribution

Indexed keywords

EXHALATION; GAS TRAPPING; HELIOX; HYPERINFLATION; LUNG; MECHANICAL VENTILATION; TIME CONSTANTS;

ELASTICITY; FORECASTING; HELIUM; MATHEMATICAL MODELS; MIXTURES; VENTILATION;

BIOLOGICAL ORGANS;

HELIUM; OXYGEN;

ADULT; AIRWAY OBSTRUCTION; ARTICLE; ARTIFICIAL VENTILATION; BIOLOGICAL MODEL; BREATHING; DRUG EFFECT; EXHALATION; HUMAN; LUNG; LUNG COMPLIANCE; PATHOPHYSIOLOGY; PHYSIOLOGY; TIME;

ADULT; AIRWAY OBSTRUCTION; EXHALATION; HELIUM; HUMANS; LUNG; LUNG COMPLIANCE; MODELS, BIOLOGICAL; OXYGEN; RESPIRATION; RESPIRATION, ARTIFICIAL; TIME FACTORS;

EID: 84861551593     PISSN: None     EISSN: 1475925X     Source Type: Journal    
DOI: 10.1186/1475-925X-11-27     Document Type: Article

References (24)

1. Farré R, Navajas D. Assessment of expiratory flow limitation in chronic obstructive pulmonary disease: a new approach. Eur Respir J 2004, 23:187-188. 10.1183/09031936.04.00131804, 14979488.
2. O'Donnell DE. Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease. Proc Am Thoracic Soc 2006, 3:180-184.
3. Permutt S. The role of the large airways on smooth muscle contraction in asthma. J Appl Physiol 2007, 103:1457-1458. 10.1152/japplphysiol.00568.2007, 17540837.
4. Barbini P, Brighenti C, Gnudi G. A simulation study of expiratory flow limitation in obstructive patients during mechanical ventilation. Annals of Biomed Eng 2006, 34:1879-1889.
5. Brighenti C, Barbini P, Gnudi G, Cevenini G, Pecchiari M, D'Angelo E. Helium-oxygen ventilation in the presence of expiratory flow-limitation: A model study. Respir Physiol Neurobiol 2007, 157:326-334. 10.1016/j.resp.2006.12.012, 17293172.
6. D'Angelo E, Santus P, Civitillo MF, Centanni S, Pecchiari M. Expiratory flow-limitation and heliox breathing in resting and exercising COPD patients. Respir Physiol Neurobiol 2009, 169:291-296. 10.1016/j.resp.2009.09.009, 19770071.
7. Pecchiari M, Pelucchi A, D'Angelo E, Foresi A, Milic-Emili J, D'Angelo E. Effect of heliox breathing on dynamic hyperinflation in COPD patients. Chest 2004, 125:2075-2082. 10.1378/chest.125.6.2075, 15189924.
8. Palange P, Valli G, Onorati P, Antonucci R, Paoletti P, Rosato A, Manfredi F, Serra P. Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients. J Appl Physiol 2004, 97:1637-1642. 10.1152/japplphysiol.01207.2003, 15234959.
9. Manthous CA, Hall JB, Melmed A, Caputo MA, Walter J, Klocksieben JM, Schmidt GA, Wood LDH. Heliox improves pulsus paradoxus and peak expiratory flow in nonintubated patients with severe asthma. Am J Respir Crit Care Med 1995, 151:310-314.
10. Papamoschou D. Theoretical validation of the respiratory benefits of helium-oxygen mixtures. Respir Physiol 1995, 99:183-190. 10.1016/0034-5687(94)00071-7, 7740207.
11. Katz IM, Martin AR, Muller P-A, Terzibachi K, Feng C-H, Caillibotte G, Sandeau J, Texereau J. The ventilation distribution of helium-oxygen mixtures and the role of inertial losses in the presence of heterogeneous airway obstructions. J Biomechanics 2011, 44:1137-1143.
12. de Lange EE, Altes TA, Patrie JT, Battiston JJ, Juersvich AP, Mugler JP, Platts-Mills TA. Changes in regional airflow obstruction over time in the lungs of patients with asthma: Evaluation with 3He MR imaging. Radiology 2009, 250:567-575. 10.1148/radiol.2502080188, 19188325.
13. Venegas JG, Schroeder T, Harris S, Winkler RT, Melo MFV. The distribution of ventilation during bronchoconstriction is patchy and bimodal: A PET imaging study. Resp Physiol Neurobiol 2005, 148:57-64.
14. Kurahashi K, Ohtsuka M, Usuda Y. Central airway occlusion underestimates intrinsic positive end-expiratory pressure: a numerical and physical simulation. Exp Lung Res 2009, 35:756-769. 10.3109/01902140902878496, 19916859.
15. Diehl J-L, Peigne V, Guérot E, Faisy C, Lecourt L, Mercat A. Helium in the adult critical care setting. Annals of Intensive Care 2011, 1:24. 10.1186/2110-5820-1-24, 3224492, 21906368.
16. Otis AB, McKerrow CB, Bartlett RA, Mead J, McIlroy MB, Selverstone NJ, Radford EP. Mechanical factors in distribution of pulmonary ventilation. J Appl Physiol 1956, 8:427-443.
17. Silva CA M, Ventura CE. A simple model illustrating the respiratory system's time constant concept. Adv Physiol Educ 2006, 30:129-130. 10.1152/advan.00011.2006, 16912150.
18. Brunner JX, Laubscher TP, Banner MJ, Iotti G, Braschi A. Simple method to measure total expiratory time constant based on the passive expiratory flow-volume curve. Crit Care Med 1995, 23:1117-1122. 10.1097/00003246-199506000-00019, 7774225.
19. Despas PJ, Leroux M, Macklem PT. Site of airway obstruction in asthma as determined by measuring maximal expiratory flow breathing air and a helium-oxygen mixture. J Clin Investig 1972, 51:3235-3243. 10.1172/JCI107150, 333005, 4640957.
20. Hamilton Medical Hamilton G5 Operator's Manual 2008, 6-22. 624074/02, Hamilton Medical.
21. Katz IM, Martin AR, Feng C-H, Majoral C, Caillibotte G, Marx T, Bazin J-E, Daviet C. Airway pressure distribution during xenon anesthesia: the insufflation phase at constant flow (volume controlled mode). Appl Cardiopulm Pathophysiol 2012, 16:5-16.
22. Lichtwarck-Aschoff M, Helmer A, Kawati R, Lattuada M, Sjostrand UH, Zugel N, Guttman J, Hedenstierna G. Good short-term agreement between measured and calculated tracheal pressure. Brit J Anesth 2003, 91:239-48.
23. Jarreau P-H, Louis B, Dassieu G, Desfrere L, Blanchard PW, Moriette G, Isabey D, Harf A. Estimation of inspiratory pressure drop in neonatal and pediatric endotracheal tubes. J Appl Physiol 1999, 87:36-46.
24. Katz I, Caillibotte G, Martin AR, Arpentinier P. Property value estimation for inhaled therapeutic binary gas mixtures: He, Xe, N2O, and N2 with O2. Med Gas Res 2011, 1:28. 10.1186/2045-9912-1-28, 3354644, 22146153.