The ventilation distribution of helium-oxygen mixtures and the role of inertial losses in the presence of heterogeneous airway obstructions

Journal of Biomechanics

Volumn 44, Issue 6, 2011, Pages 1137-1143

  Katz, Ira M ^a,b   Martin, Andrew R ^a   Muller, Pierre Antoine ^a   Terzibachi, Karine ^a   Feng, Chia Hsiang ^a   Caillibotte, Georges ^a   Sandeau, Julien ^a,c   Texereau, Joëlle ^a  

^a AIR LIQUIDE   (France)

^b LAFAYETTE COLLEGE   (United States)

^c INSERM   (France)

Author keywords

Helium oxygen; Heterogeneous obstruction; Mathematical model; Respiratory mechanics; Turbulence; Two compartment test lung

Indexed keywords

AIRWAY OBSTRUCTION; CONVECTIVE LOSS; DENSITY DEPENDENT; ENGINEERING ANALYSIS; EXPERIMENTAL PARAMETERS; FLOW RESISTANCE; GAS VOLUME; HETEROGENEOUS OBSTRUCTION; HUMAN LUNG MODELS; IN-VITRO; IN-VIVO; OXYGEN MIXTURES; REGIONAL DISTRIBUTION; RELATIVE WEIGHTS; TWO-COMPARTMENT TEST LUNG; UNIFORM DISTRIBUTION;

BIOLOGICAL ORGANS; HELIUM; MECHANICS; OXYGEN; RESPIRATORY MECHANICS; TURBULENCE;

MATHEMATICAL MODELS;

HELIUM; OXYGEN;

AIRWAY OBSTRUCTION; ARTICLE; ARTIFICIAL VENTILATION; BIOENGINEERING; COMPARTMENT MODEL; CONTROLLED STUDY; DISEASE SEVERITY; FEEDBACK SYSTEM; GAS TRANSPORT; HELIUM OXYGEN BREATHING; IN VITRO STUDY; IN VIVO STUDY; LUNG DIFFUSION; LUNG MODEL; LUNG VASCULAR RESISTANCE; LUNG VENTILATION DISTRIBUTION; PRIORITY JOURNAL; PROCESS DESIGN; RESPIRATORY AIRFLOW; TOTAL LUNG CAPACITY; TURBULENT FLOW; VALIDATION PROCESS;

ADULT; AIRWAY OBSTRUCTION; HELIUM; HUMANS; LUNG; MODELS, BIOLOGICAL; OXYGEN; PULMONARY VENTILATION;

EID: 79953027197     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2011.01.022     Document Type: Article

References (31)

1. Brighenti C., Barbini P., Gnudi G., Cevenini G., Pecchiari M., Angelo E.D. Helium-oxygen ventilation in the presence of expiratory flow-limitation: a model study. Respir. Physiol. Neurobiol. 2007, 157:326-334.
2. Corcoran T.E., Gamard S. Development of aerosol drug delivery with helium oxygen gas mixtures. J. Aerosol Med. 2004, 17:299-309.
3. de Lange E.E., Altes T.A., Patrie J.T., Battiston J.J., Juersvich A.P., Mugler J.P., Platts-Mills T.A. Changes in regional airflow obstruction over time in the lungs of patients with asthma: evaluation with 3He MR imaging. Radiology 2009, 250:567-575.
4. Dekker E. Transition between laminar and turbulent flow in the human trachea. J. Appl. Physiol. 1961, 166:1060-1064.
5. Despas P.J., Leroux M., Macklem P.T. Site of airway obstruction in asthma as determined by measureing maximal expiratory flow breathing air and a helium-oxygen mixture. J. Clin. Inv. 1972, 51:3235-3243.
6. Frazier M.D., Cheifetz I.M. The role of heliox in paediatric respiratory disease. Paediatr. Respir. Rev. 2010, 11:46-53.
7. Gemci T., Ponyavin V., Chen Y., Chen H., Collins R. Computational model of airflow in upper 17 generations of human respiratory tract. J. Biomech. 2008, 41:2047-2054.
8. Goris M.L., Zhu H.J., Blankenberg F., Chan F., Robinson T.E. An automated approach to quantitative air trapping measurements in mild sustic fibrosis. Chest 2003, 123:1655-1663.
9. Ho C.-M., Tai Y.-C. Micro-electro-mechanical systems (MEMS) and fluid flows. Annu. Rev. Fluid Mech. 1998, 30:579-612.
10. Irvin C.G., Bates H.T. Physiologic dysfunction of the asthmatic lung: what's going on down there, anyway?. Proc. Am. Thorac. Soc. 2009, 6:306-311.
11. Jaber S., Fodil R., Carlucci A., Boussarsar M., Pigeot J., Lemaire F., Harf A., Lofaso F., Isabey D., Brochard L. Noninvasive ventilation with helium-oxygen in acute exacerbations of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2000, 161:1191-1200.
12. Jolliet P., Tassaux D. Helium-oxygen ventilation. Respir. Physiol. 2002, 8:295-307.
13. Kim I.K., Phrampus E., Venkataraman S.T., Pitetti R., Saville A.L., Corcoran T.E., Gracely E., Funt N., Thompson A. Helium/oxygen-driven albuterol nebulization in the treatment of children with moderate to severe asthma exacerbations: a randomized, controlled trial. Pediatrics 2005, 116:1127-1133.
14. Kim I.K., Saville A.L., Sikes K.L., Corcoran T.E. Heliox-driven albuterol nebulization for asthma exacerbations: an overview. Respir. Care 2006, 51:613-618.
15. Ley-Zaporozhan J., Ley S., Kauczor H.-U. Morphological and functional imaging in COPD with CT and MRI: present and future. Eur. Radiol. 2008, 18:510-521.
16. Maggiore S.M., Richard J.-C.M., Abroug F., Diehl J.L., Antonelli M., Sauder P., Mancebo J., Ferrer M., Lellouche F., Lecourt L., Beduneau G., Brochard L. A multicenter, randomized trial of noninvasive ventilation with helium-oxygen mixture in exacerbations of chronic obstructive lung disease. Crit. Care Med. 2010, 38:145-151.
17. Mink S.N., Wilson T.A. How does HeO2 increase maximum expiratory flow in human lungs?. J. Clin. Invest 1980, 66:720-729.
18. O'Donnell D.E., Banzett R.B., Carrieri-Kohlman V., Casaburi R., Davenport P.W., Gandevia S.C., Gelb A.F., Mahler D.A., Webb K.A. Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable. Proc. Am. Thorac. Soc. 2007, 4:145-168.
19. Oliveira P.J., Pinho F.T. Pressure drop coefficient of laminar Newtonian flow in axisymmetric sudden expansions. Int. J. Heat Fluid Flow 1997, 18:518-529.
20. Otis, A.B., Fenn, W.O., Rahn, H., 1950. Mechanics of Breathing in Man.
21. Otis A.B., McKerrow C.B., Bartlett R.A., Mead J., McIlroy M.B., Selverstone N.J., Radford E.P. Mechanical factors in distribution of pulmonary ventilation. J. Appl. Physiol. 1956, 8:427-443.
22. Palange P., Valli G., Onorati P., Antonucci R., Paoletti P., Rosato A., Manfredi F., Serra P. Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients. J. Appl. Physiol. 2004, 97:1637-1642.
23. Papamoschou D. Theoretical validation of the respiratory benefits of helium-oxygen mixtures. Respir. Physiol. 1995, 99:183-190.
24. Pedley T.J., Schroter R.C., Sudlow M.F. Pressure flow relations in branched tubes. J. Physiol. 1969, 204:114P.
25. Pedley T.J., Schroter R.C., Sudlow M.F. The prediction of pressure drop and variation of resistance within the human bronchial airways. Respir. Physiol. 1970, 9:387-405.
26. Pedley T.J., Sudlow M.F., Milic-Emili J. A non-linear theory of the distribution of pulmonary ventilation. Respir. Physiol. 1972, 15:1-38.
27. Sandeau J., Katz I., Fodil R., Louis B., Apiou-Sbirlea G., Caillibotte G., Isabey D. CFD simulation of particle deposition in a reconstructed human oral extrathoracic airway for air and helium-oxygen mixtures. J. Aerosol Sci. 2010, 41:281-294.
28. Soong T.T., Nicolaides P., Yu C.P., Soong S.C. A statistical description of the human tracheobronchial tree geometry. Respir. Physiol. 1979, 37:161-172.
29. Venegas J.G., Schroeder T., Harris S., Winkler R.T., Melo M.F.V. The distribution of ventilation during bronchoconstriction is patchy and bimodal: a PET imaging study. Respir. Physiol. Neurobiol. 2005, 148:57-64.
30. Venegas J.G., Winkler T., Musch G., Melo M.F.V., Layfield D., Tgavalekos N., Fischman A.J., Callahan R.J., Bellani G., Harris R.S. Self-organized patchiness in asthma as a prelude to catastrophic shifts. Nature 2005, 434:777-782.
31. Zhang Z., Kleinstreuer C., Kim C.S. Flow structure and particle transport in a triple bifurcation airway model. Trans. ASME 2001, 123:320-330.