Conformational activation of poly(ADP-ribose) polymerase-1 upon DNA binding revealed by small-angle X-ray scattering

Biochemistry

Volumn 53, Issue 11, 2014, Pages 1779-1788

  Mansoorabadi, Steven O ^a,d   Wu, Meilan ^a   Tao, Zhihua ^a   Gao, Peng ^a   Pingali, Sai Venkatesh ^b   Guo, Liang ^c   Liu, Hung Wen ^a  

^a Section of Molecular Genetics and Microbiology   (United States)

^b OAK RIDGE NATIONAL LABORATORY   (United States)

^c ARGONNE NATIONAL LABORATORY   (United States)

^d AUBURN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DNA; LIGANDS; MOLECULAR DYNAMICS; PROTEINS; X RAY SCATTERING;

CONFORMATIONAL CHANGE; INTER-DOMAIN INTERACTIONS; MOLECULAR DYNAMICS SIMULATIONS; NICOTINAMIDE ADENINE DINUCLEOTIDES; POLY(ADP RIBOSE) POLYMERASE 1; POLY(ADP-RIBOSE)-POLYMERASE 1 (PARP-1); SMALL ANGLE X-RAY SCATTERING; STRUCTURAL INFORMATION;

POLYMERS;

NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1;

ALLOSTERISM; ARTICLE; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DNA BINDING; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVE SITE; ENZYME MECHANISM; LIGAND BINDING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; X RAY CRYSTALLOGRAPHY;

DNA; HUMANS; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN BINDING; PROTEIN CONFORMATION; SCATTERING, SMALL ANGLE; X-RAY DIFFRACTION;

EID: 84897083413     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi401439n     Document Type: Article

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