"Specificity determinants" improve therapeutic indices of two antimicrobial peptides piscidin 1 and dermaseptin S4 against the gram-negative pathogens Acinetobacter baumannii and Pseudomonas aeruginosa

Pharmaceuticals

Volumn 7, Issue 4, 2014, Pages 366-391

  Jiang, Ziqing ^a   Vasil, Adriana I ^a   Vasil, Michael L ^a   Hodges, Robert S ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Acinetobacter baumannii; Antimicrobial peptides; Gram negative pathogens; Pseudomonas aeruginosa; Specificity determinant(s); Temperature profiling by RP HPLC

Indexed keywords

ALPHA N ACETYLGLUTAMYLLEUCYLGLUTAMYLLYSYLGLYCYLGLYCYLLEUCYLGLUTAMYLGLYCYLGLUTAMYLLYSYLGLYCYLGLYCYLLYSYLGLUTAMYLLEUCYLGLUTAMYLLYSYLAMIDE; DERMASEPTIN S4; DERMASEPTIN S4 A14K; DERMASEPTIN S4 L7K; PISCIDIN 1; PISCIDIN 1 G13K; PISCIDIN 1 G8P; PISCIDIN 1 I9K; PISCIDIN 1 V12K; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; AMINO ACID SUBSTITUTION; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG DESIGN; DRUG ISOLATION; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ERYTHROCYTE; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PHYLLOMEDUSA; PREDICTION; PSEUDOMONAS AERUGINOSA; STRAIN DIFFERENCE; STRIPED BASS; STRUCTURE ANALYSIS; THERAPEUTIC INDEX;

EID: 84897063522     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph7040366     Document Type: Article

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