Effects of net charge and the number of positively charged residues on the biological activity of amphipathic α-helical cationic antimicrobial peptides

Biopolymers - Peptide Science Section

Volumn 90, Issue 3, 2008, Pages 369-383

  Jiang, Ziqing ^a   Vasil, Adriana I ^a   Hale, John D ^b   Hancock, Robert E W ^b   Vasil, Michael L ^a   Hodges, Robert S ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Amphipathicity; Antimicrobial activity; Antimicrobial peptide; Helicity; Hemolytic activity; Hydrophobicity; Peptide self association

Indexed keywords

ASSOCIATION REACTIONS; BACTERIA; BIOACTIVITY; BLOOD; CONCENTRATION (PROCESS); HYDROPHOBICITY; POLYPEPTIDES; TURBULENT FLOW;

AMPHIPATHIC; AMPHIPATHICITY; ANTI-MICROBIAL ACTIVITIES; ANTI-MICROBIAL PEPTIDES; ANTIMICROBIAL ACTION; ANTIMICROBIAL ACTIVITY; ANTIMICROBIAL PEPTIDE; BIOLOGICAL ACTIVITIES; BIOPHYSICAL PROPERTIES; CATIONIC ANTIMICROBIAL PEPTIDES; GRAM-POSITIVE BACTERIA; HELICITY; HEMOLYTIC ACTIVITIES; HEMOLYTIC ACTIVITY; HUMAN RED BLOOD CELLS; MINIMAL INHIBITORY CONCENTRATIONS; NET CHARGES; PEPTIDE CONCENTRATION; PEPTIDE SELF-ASSOCIATION; POSITIVE CHARGES; POSITIVELY CHARGED; PSEUDOMONAS AERUGINOSA; SELF ASSOCIATIONS; SHARP TRANSITION;

AMINES;

N ALPHA ACETYLGLUTAMYLTRYPTOPHANYLGLUTAMYLSERYLPHENYLALANYLLEUCYLGLUTAMYLTHREONYLPHENYLALANYLGLUTAMYLSERYLALANYLLYSYLGLUTAMYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLGLUTAMYLALANYLISOLEUCYLSERYLSERINE AMIDE; N ALPHA ACETYLLYSYLTRYPTOPHANYLLYSYLGLUTAMYLPHENYLALANYLLEUCYLLYSYLGLUTAMYLPHENYLALANYLLYSYLGLUTAMYLALANYLLYSYLLYSYLGLUTAMYLVALYLLEUCYLHISTIDYLGLUTAMYLALANYLLEUCYLLYSYLALANYLISOLEUCYLSERYLGLUTAMATE AMIDE; N ALPHA ACETYLLYSYLTRYTOPHANYLLYSYLGLUTAMYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYLGLUTAMYLALANYLLYSYLLYSYLGLUTAMYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYLALANYLISOLEUCYLSERYLSERINE AMIDE; N ALPHA ACETYLLYSYLTRYTOPHANYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYLSERYLALANYLLYSYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYLALANYLISOLEUCYLSERYLLYSINE AMIDE; N ALPHA ACETYLLYSYLTRYTOPHANYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLLYSYLSERYLALANYLLYSYLLYSYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYLALANYLISOLEUCYLSERYLSERINE AMIDE; N ALPHA ACETYLSERYLTRYPTOPHANYLLYSYLSERYLPHENYLALANYLLEUCYLLYSYLTHREONYLPHENYLALANYLSERYLSERYLALANYLLYSYLSERYLTHREONYLVALYLLEUCYLHISTIDYLTHREONYLALANYLLEUCYLLYSYLALANYLISOLEUCYLSERYLSERINE AMIDE; PEPTIDE DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; DRUG STRUCTURE; ELECTRICITY; ERYTHROCYTE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PEPTIDE SYNTHESIS; PH; PSEUDOMONAS AERUGINOSA; PURIFICATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; AMINO ACID SEQUENCE; CHEMISTRY; CIRCULAR DICHROISM; DRUG EFFECT; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGICAL EXAMINATION; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; SYNTHESIS; TEMPERATURE;

NEGIBACTERIA; POSIBACTERIA; PSEUDOMONAS AERUGINOSA;

AMINO ACID SEQUENCE; ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; HEMOLYSIS; HUMANS; HYDROPHOBICITY; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; PSEUDOMONAS AERUGINOSA; TEMPERATURE;

EID: 46749108538     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.20911     Document Type: Article

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