N-acylated and D enantiomer derivatives of a nonamer core peptide of lactoferricin B showing improved antimicrobial activity

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 5, 1999, Pages 1267-1269

  Wakabayashi, Hiroyuki ^a   Matsumoto, Hiroshi ^a   Hashimoto, Koichi ^a   Teraguchi, Susumu ^a   Takase, Mitsunori ^a   Hayasawa, Hirotoshi ^a  

^a MORINAGA MILK INDUSTRY CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; DRUG DERIVATIVE; LACTOFERRICIN B; UNCLASSIFIED DRUG;

ACYLATION; AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG CONJUGATION; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOMER; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL;

EID: 0032930276     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.5.1267     Document Type: Article

References (15)

1. Alvarez-Bravo, J., S. Kurata, and S. Natori. 1994. Novel synthetic antimicrobial peptides effective against methicillin-resistant Staphylococcus aureus. Biochem. J. 302:535-538.
2. Bellamy, W., M. Takase, H. Wakabayashi, K. Kawase, and M. Tomita. 1992. Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin. J. Appl. Bacteriol. 73:472-479.
3. Bellamy, W., M. Takase, K. Yamauchi, H. Wakabayashi, K. Kawase, and M. Tomita. 1992. Identification of the bactericidal domain of lactoferrin. Biochim. Biophys. Acta 1121:130-136.
4. Bellamy, W., H. Wakabayashi, M. Takase, K. Kawase, S. Shimamura, and M. Tomita. 1993. Role of cell binding in the antibacterial mechanism of lactoferricin B. J. Appl. Bacteriol. 75:478-484.
5. Chapple, D. S., D. J. Mason, C. L. Joannou, E. W. Odell, V. Gant, and R. W. Evans. 1998. Structure-function relationship of antibacterial synthetic peptides homologous to a helical surface region on human lactoferrin against Escherichia coli serotype 0111. Infect. Immun. 66:2434-2440.
6. Chen, H.-C., J. H. Brown, J. L. Morell, and C. M. Huang. 1988. Synthetic magainin analogues with improved antimicrobial activity. FEBS Lett. 236: 462-466.
7. Hoek, K. S., J. M. Milne, P. A. Grieve, D. A. Dionysius, and R. Smith, 1997. Antibacterial activity of bovine lactoferrin-derived peptides. Antimicrob. Agents Chemother. 41:54-59.
8. Houghten, R. A., C. Pinilla, S. E. Blondelle, J. R. Appel, C. T. Dooley, and J. H. Cuervo. 1991. Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery. Nature 354:84-86.
9. Hwang, P. M., N. Zhou, X. Shan, C. H. Arrowsmith, and H. J. Vogel. 1998. Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin. Biochemistry 37:4288-4298.
10. Kang, J. H., M. K. Lee, K. L. Kim, and K.-S. Hahm. 1996. Structure-biological activity relationships of 11-residue highly basic peptide segment of bovine lactoferrin. Int. J. Pept. Protein Res. 48:357-363.
11. Odell, E. W., R. Sarra, M. Foxworthy, D. S. Chapple, and R. W. Evans. 1996. Antibacterial activity of peptides homologous to a loop region in human lactoferrin. FEBS Lett. 382:175-178.
12. Wade, D., A. Boman, B. Wåhlin, C. M. Drain, D. Andreu, H. G. Boman, and R. B. Merrifield. 1990. All-D amino acid-containing channel-forming antibiotic peptides. Proc. Natl. Acad. Sci. USA 87:4761-4765.
13. Wakabayashi, H., S. Abe, T. Okutomi, S. Tansho, K. Kawase, and H. Yamaguchi. 1996. Cooperative anti-Candida effects of lactoferrin or its peptides in combination with azole antifungal agents. Microbiol. Immunol. 40: 821-825.
14. Wakabayashi, H., S. Abe, S. Teraguchi, H. Hayasawa, and H. Yamaguchi. 1998. Inhibition of hyphal growth of azole-resistant strains of Candida albicans by triazole antifungal agents in the presence of lactoferrin-related compounds. Antimicrob. Agents Chemother. 42:1587-1591.
15. Wakabayashi, H., T. Hiratani, K. Uchida, and H. Yamaguchi. 1996. Antifungal spectrum and fungicidal mechanism of an N-terminal peptide of bovine lactoferrin. J. Infect. Chemother. 1:185-189.