Structure-guided design of fluorescent S-adenosylmethionine analogs for a high-throughput screen to target SAM-I riboswitch RNAs

Chemistry and Biology

Volumn 21, Issue 3, 2014, Pages 345-356

  Hickey, Scott F ^a   Hammond, Ming C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RIBOSE; S ADENOSYLMETHIONINE; S ADENOSYLMETHIONINE 1; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; BACTERIAL RNA; CARBOCYANINE; CYANINE DYE 5; FLUORESCENT DYE; MESSENGER RNA; METHIONINE ADENOSYLTRANSFERASE; RIBOSWITCH;

ARTICLE; BINDING ASSAY; CONTROLLED STUDY; FLUORESCENCE POLARIZATION; HIGH THROUGHPUT SCREENING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RIBOSWITCH; RNA STRUCTURE; RNA SYNTHESIS; STAPHYLOCOCCUS AUREUS; ANALOGS AND DERIVATIVES; BINDING SITE; CHEMISTRY; CONFORMATION; DRUG DESIGN; DRUG EFFECTS; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MOLECULAR DYNAMICS; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS;

BACTERIAL PROTEINS; BINDING SITES; CARBOCYANINES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; FLUORESCENCE POLARIZATION; FLUORESCENT DYES; HIGH-THROUGHPUT SCREENING ASSAYS; KINETICS; METHIONINE ADENOSYLTRANSFERASE; MOLECULAR DYNAMICS SIMULATION; NUCLEIC ACID CONFORMATION; RIBOSWITCH; RNA, BACTERIAL; RNA, MESSENGER; S-ADENOSYLMETHIONINE; STAPHYLOCOCCUS AUREUS;

EID: 84897060734     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.01.004     Document Type: Article

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