MRSA virulence and spread

Cellular Microbiology

Volumn 14, Issue 10, 2012, Pages 1513-1521

  Otto, Michael ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM10 ENDOPEPTIDASE; BACTERIAL PROTEIN; CIPROFLOXACIN; CLINDAMYCIN; CYTOLYSIN; DNA FRAGMENT; ERYTHROMYCIN; EXFOLIATIN; LEUKOTOXIN; MEMBRANE PROTEIN; METICILLIN; OXACILLIN; PANTON VALENTINE LEUKOCIDIN; PENICILLIN BINDING PROTEIN 2A; PENICILLIN G; PHENOL SOLUBLE MODULIN; PSEUDOMONIC ACID; STAPHYLOCOCCUS ALPHA TOXIN; STAPHYLOCOCCUS ENTEROTOXIN; TETRACYCLINE; TOXIC SHOCK SYNDROME TOXIN 1; UNCLASSIFIED DRUG; VANCOMYCIN; VIRULENCE FACTOR;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIAL GENETICS; BACTERIAL GENOME; BACTERIAL STRAIN; BACTERIAL TRANSMISSION; BACTERIAL VIRULENCE; BIOFILM; BONE AND JOINT INFECTIONS; CLONE; COAGULASE NEGATIVE STAPHYLOCOCCUS; COMMUNICABLE DISEASE; DEVICE INFECTION; EPIDEMIC; FURUNCULOSIS; GENE EXPRESSION; GENE REARRANGEMENT; GENETIC ASSOCIATION; HOSPITAL INFECTION; HOST RESISTANCE; HUMAN; IMMUNE EVASION; IMMUNITY; LUNG INFECTION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MORTALITY; NEUTROPHIL; NONHUMAN; OSTEOMYELITIS; PHENOTYPE; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; SKIN INFECTION; SOFT TISSUE INFECTION; STAPHYLOCOCCAL BACTEREMIA;

COMMUNITY-ACQUIRED INFECTIONS; CROSS INFECTION; GENE TRANSFER, HORIZONTAL; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR EPIDEMIOLOGY; STAPHYLOCOCCAL INFECTIONS; VIRULENCE; VIRULENCE FACTORS;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;

EID: 84866337917     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2012.01832.x     Document Type: Article

References (50)

1. Abraham, E.P., and Chain, E. (1940) An enzyme from bacteria able to destroy penicillin. Nature 146: 837.
2. Amaral, M.M., Coelho, L.R., Flores, R.P., Souza, R.R., Silva-Carvalho, M.C., Teixeira, L.A., etal. (2005) The predominant variant of the Brazilian epidemic clonal complex of methicillin-resistant Staphylococcus aureus has an enhanced ability to produce biofilm and to adhere to and invade airway epithelial cells. J Infect Dis 192: 801-810.
3. Ammerlaan, H.S., Kluytmans, J.A., Wertheim, H.F., Nouwen, J.L., and Bonten, M.J. (2009) Eradication of methicillin-resistant Staphylococcus aureus carriage: a systematic review. Clin Infect Dis 48: 922-930.
4. Barber, M., and Rozwadowska-Dowzenko, M. (1948) Infection by penicillin-resistant staphylococci. Lancet 2: 641-644.
5. Bubeck Wardenburg, J., Bae, T., Otto, M., DeLeo, F.R., and Schneewind, O. (2007) Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nat Med 13: 1405-1406.
6. CDC (1999) From the Centers for Disease Control and Prevention. Four pediatric deaths from community-acquired methicillin-resistant Staphylococcus aureus - Minnesota and North Dakota, 1997-1999. JAMA 282: 1123-1125.
7. CDC (2002) Staphylococcus aureus resistant to vancomycin - United States, 2002. MMWR Morb Mortal Wkly Rep 51: 565-567.
8. Chambers, H.F., and DeLeo, F.R. (2009) Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Microbiol 7: 629-641.
9. Chatterjee, S.S., Chen, L., Joo, H.S., Cheung, G.Y., Kreiswirth, B.N., and Otto, M. (2011) Distribution and regulation of the mobile genetic element-encoded phenol-soluble modulin PSM-mec in methicillin-resistant Staphylococcus aureus PLoS ONE 6: e28781.
10. Cheung, G.Y., Wang, R., Khan, B.A., Sturdevant, D.E., and Otto, M. (2011) Role of the accessory gene regulator agr in community-associated methicillin-resistant Staphylococcus aureus pathogenesis. Infect Immun 79: 1927-1935.
11. Cremieux, A.C., Dumitrescu, O., Lina, G., Vallee, C., Cote, J.F., Muffat-Joly, M., etal. (2009) Panton-valentine leukocidin enhances the severity of community-associated methicillin-resistant Staphylococcus aureus rabbit osteomyelitis. PLoS ONE 4: e7204.
12. DeLeo, F.R., and Chambers, H.F. (2009) Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era. J Clin Invest 119: 2464-2474.
13. DeLeo, F.R., Kennedy, A.D., Chen, L., Bubeck Wardenburg, J., Kobayashi, S.D., Mathema, B., etal. (2011) Molecular differentiation of historic phage-type 80/81 and contemporary epidemic Staphylococcus aureus Proc Natl Acad Sci USA 108: 18091-18096.
14. Diekema, D.J., Pfaller, M.A., Schmitz, F.J., Smayevsky, J., Bell, J., Jones, R.N., and Beach, M. (2001) Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillance Program, 1997-1999. Clin Infect Dis 32 (Suppl. 2): S114-S132.
15. Diep, B.A., Chambers, H.F., Graber, C.J., Szumowski, J.D., Miller, L.G., Han, L.L., etal. (2008) Emergence of multidrug-resistant, community-associated, methicillin-resistant Staphylococcus aureus clone USA300 in men who have sex with men. Ann Intern Med 148: 249-257.
16. Diep, B.A., Chan, L., Tattevin, P., Kajikawa, O., Martin, T.R., Basuino, L., etal. (2010) Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury. Proc Natl Acad Sci USA 107: 5587-5592.
17. von Eiff, C., Becker, K., Machka, K., Stammer, H., and Peters, G. (2001) Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group. N Engl J Med 344: 11-16.
18. Foster, T.J., and Hook, M. (1998) Surface protein adhesins of Staphylococcus aureus Trends Microbiol 6: 484-488.
19. Hanberger, H., Walther, S., Leone, M., Barie, P.S., Rello, J., Lipman, J., etal. (2011) Increased mortality associated with meticillin-resistant Staphylococcus aureus (MRSA) infection in the intensive care unit: results from the EPIC II study. Int J Antimicrob Agents 38: 331-335.
20. Hartman, B., and Tomasz, A. (1981) Altered penicillin-binding proteins in methicillin-resistant strains of Staphylococcus aureus Antimicrob Agents Chemother 19: 726-735.
21. Hiramatsu, K., Cui, L., Kuroda, M., and Ito, T. (2001) The emergence and evolution of methicillin-resistant Staphylococcus aureus Trends Microbiol 9: 486-493.
22. Jevons, M.P., Coe, A.W., and Parker, M.T. (1963) Methicillin resistance in staphylococci. Lancet 1: 904-907.
23. Joshi, G.S., Spontak, J.S., Klapper, D.G., and Richardson, A.R. (2011) Arginine catabolic mobile element encoded speG abrogates the unique hypersensitivity of Staphylococcus aureus to exogenous polyamines. Mol Microbiol 82: 9-20.
24. Katayama, Y., Ito, T., and Hiramatsu, K. (2000) A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus Antimicrob Agents Chemother 44: 1549-1555.
25. Klevens, R.M., Morrison, M.A., Nadle, J., Petit, S., Gershman, K., Ray, S., etal. (2007) Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 298: 1763-1771.
26. Kobayashi, S.D., Malachowa, N., Whitney, A.R., Braughton, K.R., Gardner, D.J., Long, D., etal. (2011) Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection. J Infect Dis 204: 937-941.
27. Li, M., Diep, B.A., Villaruz, A.E., Braughton, K.R., Jiang, X., DeLeo, F.R., etal. (2009) Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus Proc Natl Acad Sci USA 106: 5883-5888.
28. Li, M., Cheung, G.Y., Hu, J., Wang, D., Joo, H.S., Deleo, F.R., and Otto, M. (2010) Comparative analysis of virulence and toxin expression of global community-associated methicillin-resistant Staphylococcus aureus strains. J Infect Dis 202: 1866-1876.
29. Li, M., Du, X., Villaruz, A.E., Diep, B.A., Wang, D., Song, Y., etal. (2012) MRSA epidemic linked to a quickly spreading colonization and virulence determinant. Nat Med 18: 816-819.
30. Lipinska, U., Hermans, K., Meulemans, L., Dumitrescu, O., Badiou, C., Duchateau, L., etal. (2011) Panton-Valentine leukocidin does play a role in the early stage of Staphylococcus aureus skin infections: a rabbit model. PLoS ONE 6: e22864.
31. Lowy, F.D. (1998) Staphylococcus aureus infections. N Engl J Med 339: 520-532.
32. Nakamura, A., Miyake, K., Misawa, S., Kuno, Y., Horii, T., Hori, S., etal. (2012) Association between antimicrobial consumption and clinical isolates of methicillin-resistant Staphylococcus aureus: a 14-year study. J Infect Chemother 18: 90-95.
33. Novick, R.P., Ross, H.F., Projan, S.J., Kornblum, J., Kreiswirth, B., and Moghazeh, S. (1993) Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. EMBO J 12: 3967-3975.
34. O'Brien, L.M., Walsh, E.J., Massey, R.C., Peacock, S.J., and Foster, T.J. (2002) Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization. Cell Microbiol 4: 759-770.
35. Otto, M. (2008) Staphylococcal biofilms. Curr Top Microbiol Immunol 322: 207-228.
36. Otto, M. (2010) Basis of virulence in community-associated methicillin-resistant Staphylococcus aureus Annu Rev Microbiol 64: 143-162.
37. Peschel, A. (2002) How do bacteria resist human antimicrobial peptides? Trends Microbiol 10: 179-186.
38. Queck, S.Y., Khan, B.A., Wang, R., Bach, T.H., Kretschmer, D., Chen, L., etal. (2009) Mobile genetic element-encoded cytolysin connects virulence to methicillin resistance in MRSA. PLoS Pathog 5: e1000533.
39. Rammelkamp, C.H., and Maxon, T. (1942) Resistance of Staphylococcus aureus to the action of penicillin. Proc R Soc Exp Biol Med 51: 386-389.
40. Roche, F.M., Meehan, M., and Foster, T.J. (2003) The Staphylococcus aureus surface protein SasG and its homologues promote bacterial adherence to human desquamated nasal epithelial cells. Microbiology 149: 2759-2767.
41. Roundtree, P.M., and Freeman, B.M. (1956) Infections caused by a particular phage type of Staphylococcus aureus Med J Aust 42: 157-161.
42. Rudkin, J.K., Edwards, A.M., Bowden, M.G., Brown, E.L., Pozzi, C., Waters, E.M., etal. (2012) Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system. J Infect Dis 205: 798-806.
43. Shopsin, B., Drlica-Wagner, A., Mathema, B., Adhikari, R.P., Kreiswirth, B.N., and Novick, R.P. (2008) Prevalence of agr dysfunction among colonizing Staphylococcus aureus strains. J Infect Dis 198: 1171-1174.
44. Shorr, A.F. (2007) Epidemiology of staphylococcal resistance. Clin Infect Dis 45 (Suppl. 3): S171-S176.
45. Vandenesch, F., Naimi, T., Enright, M.C., Lina, G., Nimmo, G.R., Heffernan, H., etal. (2003) Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence. Emerg Infect Dis 9: 978-984.
46. Wang, R., Braughton, K.R., Kretschmer, D., Bach, T.H., Queck, S.Y., Li, M., etal. (2007) Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med 13: 1510-1514.
47. Weidenmaier, C., Kokai-Kun, J.F., Kristian, S.A., Chanturiya, T., Kalbacher, H., Gross, M., etal. (2004) Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections. Nat Med 10: 243-245.
48. Wertheim, H.F., Vos, M.C., Ott, A., van Belkum, A., Voss, A., Kluytmans, J.A., etal. (2004) Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers. Lancet 364: 703-705.
49. Wertheim, H.F., Melles, D.C., Vos, M.C., van Leeuwen, W., van Belkum, A., Verbrugh, H.A., and Nouwen, J.L. (2005) The role of nasal carriage in Staphylococcus aureus infections. Lancet Infect Dis 5: 751-762.
50. Wilson, G.J., Seo, K.S., Cartwright, R.A., Connelley, T., Chuang-Smith, O.N., Merriman, J.A., etal. (2011) A novel core genome-encoded superantigen contributes to lethality of community-associated MRSA necrotizing pneumonia. PLoS Pathog 7: e1002271.