Exchange protein directly activated by cAMP mediates slow delayed-rectifier current remodeling by sustained β-adrenergic activation in guinea pig hearts

Circulation Research

Volumn 114, Issue 6, 2014, Pages 993-1003

  Aflaki, Mona ^a,b   Qi, Xiao Yan ^a   Xiao, Ling ^a   Ordog, Balazs ^a   Tadevosyan, Artavazd ^a   Luo, Xiaobin ^a   Maguy, Ange ^a   Shi, Yanfen ^a   Tardif, Jean Claude ^a   Nattel, Stanley ^a,b  

^a MONTREAL HEART INSTITUTE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

arrhythmias; calcineurin; cardiac; heart failure; ion channels; adrenergic receptors

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; ANTIPORTER; CALCINEURIN; CYCLIC AMP; CYCLIC AMP DERIVATIVE; CYCLOSPORIN; DELAYED RECTIFIER POTASSIUM CHANNEL; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CYCLIC AMP; ISOPRENALINE; MEMBRANE PROTEIN; MESSENGER RNA; NUCLEAR FACTOR; POTASSIUM CHANNEL KCNE1; PROTEIN INHIBITOR; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ADENOVIRUS; ADRENERGIC STIMULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC STIMULATION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG EXPOSURE; ELECTROPHYSIOLOGY; ENZYME INHIBITION; GUINEA PIG; HEART ARRHYTHMIA; HEART DISEASE; HEART LEFT VENTRICLE; HEART MUSCLE CELL; IMMUNOFLUORESCENCE; IN VIVO STUDY; NONHUMAN; PRIMARY CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TISSUE REGENERATION; WHOLE CELL PATCH CLAMP;

ARRHYTHMIAS, CARDIAC; CALCINEURIN; HEART FAILURE; ION CHANNELS; Β-ADRENERGIC RECEPTORS;

ACTION POTENTIALS; ADRENERGIC BETA-AGONISTS; ANIMALS; CALCINEURIN; CALCIUM; CELLS, CULTURED; COLFORSIN; CYCLIC AMP; DELAYED RECTIFIER POTASSIUM CHANNELS; EGTAZIC ACID; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUINEA PIGS; HYPERTROPHY, LEFT VENTRICULAR; IMIDAZOLES; ION CHANNEL GATING; ISOPROTERENOL; MYOCYTES, CARDIAC; NFATC TRANSCRIPTION FACTORS; PATCH-CLAMP TECHNIQUES; POTASSIUM; PROPANOLAMINES; RECEPTORS, ADRENERGIC, BETA-1; RNA INTERFERENCE; RNA, SMALL INTERFERING; SECOND MESSENGER SYSTEMS;

EID: 84897056371     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.113.302982     Document Type: Article

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