Molecular correlates of altered expression of potassium currents in failing rabbit myocardium

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 288, Issue 5 57-5, 2005, Pages

  Rose, Jochen ^a   Armoundas, Antonis A ^a   Tian, Yanli ^a   DiSilvestre, Deborah ^a   Burysek, Miroslava ^a   Halperin, Victoria ^a   O'Rourke, Brian ^a   Kass, David A ^a   Marbán, Eduardo ^a   Tomaselli, Gordon F ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Action potential; Heart failure; IK1; IK; Ito

Indexed keywords

BINDING PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; KCHIP2 PROTEIN; KIR2.1 PROTEIN; KV1.4 PROTEIN; KV4.2 PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HEART FAILURE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE POTENTIAL; HEART PACING; HEART REPOLARIZATION; HEART WEIGHT; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; POTASSIUM CURRENT; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBONUCLEASE PROTECTION ASSAY; RNA PROBE; WESTERN BLOTTING;

ACTION POTENTIALS; ANIMALS; CALCIUM-BINDING PROTEINS; FEMALE; GENE EXPRESSION; HEART FAILURE, CONGESTIVE; KCNQ POTASSIUM CHANNELS; KCNQ1 POTASSIUM CHANNEL; KV CHANNEL-INTERACTING PROTEINS; KV1.4 POTASSIUM CHANNEL; MALE; POTASSIUM; POTASSIUM CHANNELS, INWARDLY RECTIFYING; POTASSIUM CHANNELS, VOLTAGE-GATED; RABBITS; RNA, MESSENGER; SHAL POTASSIUM CHANNELS;

EID: 20944452268     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00526.2003     Document Type: Article

References (53)

1. Ahmmed GU, Dong PH, Song G, Ball NA, Xu Y, Walsh RA, and Chiamvimonvat N. Changes in Ca(2+) cycling proteins underlie cardiac action potential prolongation in a pressure-overloaded guinea pig model with cardiac hypertrophy and failure. Circ Res 86: 558-570, 2000.
2. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, and Rhodes KJ. Modulation of A-type potassium channels by a family of calcium sensors. Nature 403: 553-556, 2000.
3. Antzelevitch C, Sicouri S, Litovsky SH, Lukas A, Kishnan SC, Di Diego JM, Gintant GA, and Liu DW. Heterogeneity within the ventricular wall eElectrophysiology and pharmacology of epicardial, endocardial, and M cells. Circ Res 69: 1427-1449, 1991.
4. Armoundas AA, Wu R, Juang G, Marban E, and Tomaselli GF. Electrical and structural remodeling of the failing ventricle. Pharmacol Ther 92: 213-230, 2001.
5. Beuckelmann DJ, Nabauer M, and Erdmann E. Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure. Circ Res 73: 379-385, 1993.
6. 2+. J Physiol 414: 499-520, 1989.
7. + current changes and action potential duration. J Am Coll Cardiol 41: 1611-1622, 2003.
8. Brooksby P, Levi AJ, and Jones JV. The electrophysiological characteristics of hypertrophied ventricular myocytes from the spontaneously hypertensive rat. J Hypertens 11: 611-622, 1993.
9. Cerbai E, Barbieri M, Li Q, and Mugelli A. Ionic basis of action potential prolongation of hypertrophied cardiac myocytes isolated from hypertensive rats of different ages. Cardiovasc Res 28: 1180-1187, 1994.
10. + current in rabbit ventricular myocytes. Cardiovasc Res 31: 963-974,1996.
11. Choy AM, Kuperschmidt S, Lang CC, Pierson RN, and Roden DM. Regional expression of HERG and KvLQT1 in heart failure (Abstract). Circulation 94: 164, 1996.
12. Cohn JN, Archibald DG, Ziesche S, Franciosa JA, Harston WE, Tristani FE, Dunkman WB, Jacobs W, Francis GS, Flohr KH, Goldman S, Cobb FR, Shan PM, Saunders R, Fletcher RD, Loeb HS, Hughes VC, and Baker B. Effect of vasodilator therapy on mortality in chronic congestive heart failure Results of a Veterans Administration Cooperative Study. N Engl J Med 314: 1547-1552, 1986.
13. Deschenes I, DiSilvestre D, Juang GJ, Wu RC, An WF, and Tomaselli GF. Regulation of Kv4.3 current by KChlP2 splice variants: a component of native cardiac T(to)? Circulation 106: 423-429, 2002.
14. o-induced electrical heterogeneity and extrasystolic activity in isolated canine ventricular epicardium. Phase 2 reentry. Circulation 89: 1839-1850, 1994.
15. Dixon JE and McKinnon D. Quantitative analysis of potassium channel mRNA expression in atrial and ventricular muscle of rats. Circ Res 75: 252-260, 1994.
16. + channel in ventricular muscle. A molecular correlate for the transient outward current. Circ Res 79: 659-668, 1996.
17. + current in rat ventricle. J Physiol 500: 51-64, 1997.
18. Furukawa T, Bassett AL, Furukawa N, Kimura S, and Myerburg RJ. The ionic mechanism of reperfusion-induced early afterdepolarizations in feline left ventricular hypertrophy. J Clin Invest 91: 1521-1531, 1993.
19. K differs in feline left ventricular hypertrophy. Am J Physiol Heart Circ Physiol 266: H1121-H1131, 1994.
20. Greenstein JL, Wu R, Po S, Tomaselli GF, and Winsiow RL. Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration. Circ Res 87: 1026-1033, 2000.
21. + current on the guinea pig action potential. Circ Res 84: 964-972, 1999.
22. Johns DC, Nuss HB, and Marban E. Suppression of neuronal and cardiac transient outward currents by viral gene transfer of dominant-negative Kv4.2 constructs. J Biol Chem 272: 31598-31603. 1997.
23. Kääb S, Dixon J, Due J, Ashen MD, Näbauer M, Beuckelmann DJ, McKinnon D, and Tumaselli GF. Molecular basis of transient outward current downregulation in human heart failure: a decrease in Kv4.5 mRNA correlates with a reduction in current density. Circulation 98: 1383-1393, 1998.
24. Kääb S, Nuss HB, Chiamvimonvat N, O'Rourke B, Pak PH, Kass DA, Marban E, and Tomaselli GF. Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing induced heart failure. Circ Res 78: 262-273, 1996.
25. Keating MT and Sanguinetti MC. Molecular genetic insights into-cardiovascular disease. Science 212: 681-685, 1996.
26. Kleiman RB and Houser RS. Outward currents in normal and hypertrophied feline ventricular myocytes. Am J Physiol Heart Circ Physiol 256: H1450-H1451, 1989.
27. to: further diversity by alternative mRNA splicing. Am J Physiol Heart Circ Physiol 275: H1963-H1970, 1998.
28. Li GR, Lau CP, Ducharme A, Tardif JC, and Nattel S. Transmural action potential and ionic current remodeling in ventricles of failing canine hearts. Am J Physiol Heart Circ Physiol 283: H1031-H1041, 2002.
29. Li Q and Keung EC. Effects of myocardial hypertrophy on transient outward current. Am J Physiol Heart Circ Physiol 266: H1738-H1745, 1994.
30. + currents by protein kinase C and adenosine implications for ischemic preconditioning. Circ Res 78: 443-454, 1996.
31. Marx SO, Kurokawa J, Reiken S, Motoike H, D'Armiento J, Marks AR, and Kass RS. Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science 295: 496-499, 2002.
32. Melnyk P, Zhang L, Shrier A, and Nattel S. Differential distribution of Kir2.1 and Kir23 subunits in canine atrium and ventricle. Am J Physiol Heart Circ Physiol 283: H1123-H1133, 2002.
33. O'Rourke B, Peng LF, Kääb S, Tunin R, Tomaselli GF, and Marban E. Mechanisms of altered exciation-contraction coupling in canine tachycardia-induced heart failure I: experimental studies. Circ Res 84: 562-570, 1999.
34. Packer M. Lack of relation between ventricular arrhythmias and sudden death in patients with chronic heart failure. Circulation 85: 150-156, 1992.
35. Pak PH, Nuss HB, Tunin RS, Kääb S, Tomaselli GF, Marban E, and Kass DA. Repolarization abnormalities, arrhythmias and sudden death in canine tachycardia-induced cardiomyopathy. J Am Coll Cardiol 30: 576-584, 1997.
36. Po S, Roberds S, Snyders DJ, Tamkun MM, and Bennett PB. Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current? Circ Res 72: 1326-1336, 1993.
37. Pogwizd SM, Schlotthauer K, Li L, Yuan W, and Bers DM. Arrhythmogenesis and contractile dysfunction in heart failure: roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. Circ Res 88: 1159-1167, 2001.
38. Ramakers C, Vos MA, Doevendans PA, Schoenmakers M, Wu YS, Scicchitano S, Iodice A, Thomas GP, Antzelevitch C, and Dumaine R. Coordinated down-regulation of KCNQ1 and KCNE1 expression contributes to reduction of I(Ks) in canine hypertrophied hearts. Cardiovasc Res 57: 486-496, 2003.
39. Rosati B, Pan Z, Lypen S, Wang HS, Cohen I, Dixon JE, and McKinnon D. Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. J Physiol 533: 119-125, 2001.
40. Rozanski GJ, Xu L, Zhang K, and Patel KP. Altered ionic currents of ventricular myocytes in rats with experimental heart failure. Am J Physiol Heart Circ Physiol 274: H259-H265, 1998.
41. Rozanski GJ, Xu Z, Whitney RT, Murakami H, and Zucker IH. Electrophysiology of rabbit ventricular myocytes following sustained rapid ventricular pacing. J Mol Cell Cardiol 29: 721-732, 1997.
42. Ryder KO, Bryant SM, and Hart G. Membrane current changes in left ventricular myocytes isolated from guinea pigs after abdominal aortic coarctation. Cardiovasc Res 27: 1278-1287, 1993.
43. Schroeder BC, Waldegger S, Fehr S, Bleich M, Warth R, Greger R, and Jentsch TJ. A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403: 196-199, 2000.
44. Stevenson WG, Stevenson LW, Middlekauff HR, and Saxon LA. Sudden death prevention in patients with advanced ventricular dysfunction. Circulation 88: 2953-2961, 1993.
45. Tinel N, Diochot S, Lauritzen I, Barhanin J, Lazdunski M, and Borsotto M. M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit. FEBS Lett 480: 137-141, 2000.
46. Tsuji Y, Opthof T, Kamiya K, Yasui K, Liu W, Lu Z, and Kodama I. Pacing-induced heart failure causes a reduction of delayed rectifier potassium currents along with decreases in calcium and transient outward currents in rabbit ventricle. Cardiovasc Res 48: 300-309, 2000.
47. Volders PG, Sipido KR, Vos MA, Spatjens RL, Leunissen JD, Carmeliet E, and Wellens UJ. Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes. Circulation 100: 2455-2461, 1999.
48. Volders PGA, Sipido KR, Carmeliet E, Spatjens R, and Vos MA. Repolarizing K+ currents Ito1 and IKs are larger in the right than the left ventricular midmyocardium of the dog. Circulation 98: 1-611, 1998.
49. Walsh KB and Kass MS. Regulation of a heart potassium channel by protein kinase A and C. Science 242: 67-69, 1988.
50. Wang Z, Feng J, Shi H, Pond A, Nerbonne JM, and Nattel S. Potential molecular basis of different physiological properties of the transient outward K+ current in rabbit and human atrial myocytes. Circ Res 84: 551-561, 1999.
51. Wettwer E, Amos GJ, Posival H, and Ravens U. Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin. Circ Res 75: 473-482, 1994.
52. + channel gene expression in rat ventricle. J Physiol 504: 271-286, 1997.
53. Winslow RL, Rice J, Jafri S, Marban E, and O'Rourke B. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies. Circ Res 84: 571-586, 1999.