Histatins: Salivaryx peptides with copper(II)- and zinc(II)-binding motifs Perspectives for biomedical applications

FEBS Journal

Volumn 281, Issue 3, 2014, Pages 657-672

  Melino, Sonia ^a   Santone, Celeste ^a   Di Nardo, Paolo ^b   Sarkar, Bibudhendra ^c  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

ACTUN motif; Antimicrobial peptides; Candida albicans; Histidine rich peptide; Metallopeptides; Metalloprotease inhibitor; Reactive oxygen species; Saliva; Wound healing

Indexed keywords

ATCUNC16; CUPRIC ION; DH5; DHVAR 4; DHVAR 5; EPIDERMAL GROWTH FACTOR; HIST1CT; HISTATIN; HISTATIN 1; HISTATIN 10; HISTATIN 11; HISTATIN 12; HISTATIN 2; HISTATIN 3; HISTATIN 4; HISTATIN 5; HISTATIN 6; HISTATIN 7; HISTATIN 8; HISTATIN 9; HISTATIN C TER; JH 8194; LL 37 LINKER HISTATIN 5; MATRIX METALLOPROTEINASE; P 113D; POLYPEPTIDE ANTIBIOTIC AGENT; SARALASIN; UNCLASSIFIED DRUG; ZINC ION; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; COPPER; CYSTEINE PROTEINASE INHIBITOR; ISOPROTEIN; MATRIX METALLOPROTEINASE INHIBITOR; METALLOPROTEINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; ZINC;

AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; BINDING SITE; BIOTECHNOLOGY; CYSTIC FIBROSIS; DRUG STRUCTURE; GINGIVITIS; HUMAN; LUNG INFECTION; METAL BINDING; MOUTH INFECTION; MOUTH PLAQUE; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN MOTIF; REVIEW; SALIVA; STRUCTURE ACTIVITY RELATION; THRUSH; WOUND HEALING; ACTUN MOTIF; ANIMAL; ANTIMICROBIAL PEPTIDES; CANDIDA ALBICANS; CHEMISTRY; DRUG EFFECT; HISTIDINE RICH PEPTIDE; METABOLISM; METALLOPEPTIDES; PROTEIN CONFORMATION;

CANDIDA ALBICANS; VERTEBRATA;

ACTUN MOTIF; ANTIMICROBIAL PEPTIDES; CANDIDA ALBICANS; HISTIDINE RICH PEPTIDE; METALLOPEPTIDES; METALLOPROTEASE INHIBITOR; REACTIVE OXYGEN SPECIES; SALIVA; WOUND HEALING;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; COPPER; CYSTEINE PROTEINASE INHIBITORS; HISTATINS; HUMANS; MATRIX METALLOPROTEINASE INHIBITORS; PROTEIN CONFORMATION; PROTEIN ISOFORMS; WOUND HEALING; ZINC;

EID: 84897033162     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12612     Document Type: Review

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