Transcriptional regulation of the salivary histatin gene: Finding of a strong positive regulatory element and its binding protein

Journal of Biochemistry

Volumn 145, Issue 3, 2009, Pages 279-288

  Imamura, Yasuhiro ^a   Fujigaki, Yoshihisa ^a   Oomori, Yuriko ^a   Ouryouji, Ken ^a   Yanagisawa, Shigeru ^a   Miyazawa, Hiroo ^a   Wang, Pao Li ^a  

^a MATSUMOTO DENTAL UNIVERSITY   (Japan)

Author keywords

DNA binding proteins; Histatin; Positive regulatory element; Saliva; Transcriptional regulation

Indexed keywords

DNA BINDING PROTEIN; DOUBLE STRANDED DNA; HISTATIN; SINGLE STRANDED DNA; NUCLEAR PROTEIN; NUCLEOTIDE;

ANIMAL CELL; ARTICLE; CELL STRAIN COS7; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; SALIVA LEVEL; SALIVARY GLAND; TRANSCRIPTION REGULATION; ANIMAL; ANTIBODY SPECIFICITY; CELL STRAIN 3T3; CELL STRAIN COS1; CERCOPITHECUS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; MOLECULAR WEIGHT; PROTEIN BINDING; SALIVA;

CANDIDA ALBICANS;

ANIMALS; BASE SEQUENCE; CERCOPITHECUS AETHIOPS; CLONING, MOLECULAR; COS CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HELA CELLS; HISTATINS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; NIH 3T3 CELLS; NUCLEAR PROTEINS; NUCLEOTIDES; ORGAN SPECIFICITY; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SALIVA; SEQUENCE DELETION; TRANSCRIPTION, GENETIC;

EID: 66549129983     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvn165     Document Type: Article

References (47)

1. Tenovuo, J. (1998) Antimicrobial function of human saliva - how important is it for oral health? Acta Odontol. Scand. 56, 250-256
2. Pollock, J.J., Denepitiya, L., MacKay, B.J., and Ianoco, V.J. (1984) Fungistatic and fungicidal activity of human parotid salivary histidine-rich polypeptides on Candida albicans. Infect. Immun. 44, 702-707
3. Oppenheim, F.G., Xu, T., McMillian, F.M., Levitz, S.M., Diamond, R.D., Offner, G.D., and Troxler, R.F. (1988) Histatins, a novel family of histidine-rich proteins in human parotid secretion. J. Biol. Chem. 263, 7472-7477
4. Wang, P.-L., Kanehira, T., Nagai, N., Nagatsuka, H., Imamura, Y., Tanaka, J., and Kuboki, Y. (2005) Localization of histatins in human oral tissues by immunohistochemical analysis. Dent. Jpn 41, 39-41
5. Lal, K., Pollock, J.J., Santarpia, R.P., III, Heller, H.M., Kaufman, H.W., Fuhrer, J., and Steigbigel, R.T. (1992) Pilot study comparing the salivary cationic protein concentrations in healthy adults and AIDS patients: correlation with antifungal activity. J. Acquir. Immun. Defic. Syndr. 5, 904-914
6. Sabatini, L. and Azen, E.A. (1989) Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2). Biochem. Biophys. Res. Commun. 160, 495-502
7. Hay, D.I. (1973) The interaction of human parotid salivary proteins with hydroxyl apatite. Arch. Oral Biol. 18, 1517-1529
8. Hay, D.I. (1975) Fractionation of human parotid salivary proteins and the isolation of an histidine-rich acidic peptide which shows high affinity for hydroxyapatite surfaces. Arch. Oral Biol. 20, 553-558
9. Oppenheim, F.G., Yang, Y.C., Diamond, R.D., Hyslop, D., Offner, G.D., and Troxler, R.F. (1986) The primary structure and function characterization of the neutral histidine-rich polypeptide from human parotid secretion. J. Biol. Chem. 261, 1177-1182
10. Troxler, R.F., Offner, G.D., Xu, T., Vanderspek, J.C., and Oppenheim, F.G. (1990) Structural relationship between salivary histatins. J. Dent. Res. 69, 2-6
11. Perinpanayagam, H.E.R., VanWuyckhuyse, B.C., Ji, Z.S., and Tabak, L.A. (1995) Characterization of low-molecular-weight peptides in human parotid saliva. J. Dent. Res. 74, 345-350
12. Raji, P.A., Edgerton, M., and Levin, M.J. (1990) Salivary histatin 5: dependence of sequence, chain length, and helical conformation for candidacidal activity. J. Biol. Chem. 265, 3898-3905
13. Xu, T., Levitz, M., Diamond, R., and Oppenheim, F.G. (1991) Anticandidal activity of major human salivary histatins. Infect. Immun. 59, 2549-2554
14. Xu, Y., Ambudkar, I., Yamagishi, H., Swain, W., Walsh, T.G., and O'Connell, B.C. (1999) Histatin 3-mediated killing of Candida albicans: effect of extracellular salt concentration on binding and internalization. Antimicrobe. Agents Chemother. 43, 2256-2262
15. Edgerton, M., Koshlukova, S.E., Lo, T.E., Chrzan, B.G., Straubinger, R.M., and Raj, P.A. (1998) Candidacidal activity of salivary histatins. J. Biol. Chem. 273, 20438-20447
16. Li, X.S., Reddy, M.S., Baev, D., and Edgerton, M. (2003) Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5. J. Biol. Chem. 278, 28553-28561
17. Helmerhorst, E.J., Breeuwer, P., van't Hof, W., Walgreen-Wetering, E., Oomen, L.C., Veerman, E.C., Amerongen, A.V., and Abee, T. (1999) The cellular target of histatin 5 on Candida albicans is the energized mitochondrion. J. Biol. Chem. 274, 7286-7291
18. Helmerhorst, E.J., Troxler, R.F., and Oppenheim, F.G. (2001) The human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive oxygen species. Proc. Natl Acad. Sci. USA 98, 14637-14642
19. Baev, D., Li, X.S., Dong, J., Keng, P., and Edgerton, M. (2002) Human salivary histatin 5 cases disordered volume regulation and cell cycle arrest in Candida albicans. Infect. Immun. 70, 4777-4784
20. Koshlukova, S.E., Lloyd, T.L., Araujo, M.W.B., and Edgerton, M. (1999) Salivary histatin 5 induces non-lytic release of ATP from Candida albicans leading to cell death. J. Biol. Chem. 274, 18872-18879
21. Nishikata, M., Kanehira, T., Oh, H., Tani, H., Tazaki, M., and Kuboki, Y. (1991) Salivary histatin as an inhibitor of a protease produced by the oral Bacterium Bacteroides gingivalis. Biochem. Biophys. Res. Commun. 174, 625-630
22. Gusman, H., Grogan, J., Kagan, H.M., Troxler, R.F., and Oppenheim, F.G. (2001) Salivary histatin 5 is a potent competitive inhibitor of the cysteine protease clostripain. FEBS Lett. 489, 97-100 (Pubitemid 32176013)
23. Sugiyama, K., Suzuki, Y., and Furuta, H. (1985) Isolation and characterization of histamine-releasing peptides from human parotid saliva. Life Sci. 37, 475-480 (Pubitemid 15068202)
24. Yoshida, M., Kimura, T., Kitaichi, K., Suzuki, R., Baba, K., Matsushima, M., Tatsumi, Y., Shibata, E., Takagi, K., Hasegawa, T., and Takagi, K. (2001) Induction of histamine release from rat peritoneal mast cells by histatins. Biol. Pharm. Bull. 24, 1267-1270
25. Murakami, Y., Nagata, H., Shizukuishi, S., Nakashima, K., Okawa, T., Takigawa, M., and Tsunemitsu, A. (1994) Histatin as a synergistic stimulator with epidermal growth factor of rabbit chondrocyte proliferation. Biochem. Biophys. Res. Commun. 198, 274-280
26. Fitzgerald, D.H., Coleman, D.C., and O'Connell, B.C. (2003) Binding, internalization and degradation of histatin 3 in histatin-resistant derivatives of Candida albicans. FEMS Microbiol. Lett. 220, 247-253
27. Edlund, T., Walker, M.D., Barr, P.J., and Rutter, W.J. (1985) Cell-specific expression of the rat insulin gene: evidence for role two distinct 5′ flanking elements. Science 230, 912-916 (Pubitemid 16193988)
28. Gerster, T., Matthias, P., Thali, M., Jiricny, J., and Schaffner, W. (1987) Cell type-specificity elements of the immunoglobulin heavy chain gene. EMBO J. 6, 1323-1330
29. Walker, M.D., Edlund, T., Boulet, A.M., and Rutter, W.J. (1983) Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes. Nature 306, 557-561 (Pubitemid 14203819)
30. Petropoulos, C.J., Rosenberg, M.P., Jenkins, N.A., Copeland, N.G., and Hughes, S.H. (1989) The chicken skeletal muscle alpha-actin promoter is tissue specific in transgenic mice. Mol. Cell Biol. 9, 3785-3792
31. Sobocki, T., Jayman, F., Sobocka, M.B., Marmur, J.D., and Banerjee, P. (2007) Isolation, sequencing, and functional analysis of the TATA-less murine ATPase promoter and structural analysis of the ATPase II gene. Biochim. Biophys. Acta 1769, 61-75
32. Thomson, R.B., Igarashi, P., Biemesder, D., Kim, R., Abu-Alfa, A., Soleimani, M., and Aronson, P.S. (1995) Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family. J. Biol. Chem. 270, 17594-17601
33. Nakamura, Y., Inoue, M., Okumura, Y., Shiota, M., Nishikawa, M., Arase, S., and Kido, H. (2003) Cloning, expression analysis, and tissue distribution of esp-1/testisin, a membrane-type serine protease from the rat. J. Med. Invest. 50, 78-86
34. vanderSpek, J.C., Offner, G.D., Troxler, R.F., and Oppenheim, F.G. (1990) Molecular cloning of human submandibular histatins. Arch. Oral Biol. 35, 137-143
35. Imamura, Y., Wang, P.-L., Kuno, T., Otogoto, J., Fujii, T., and Ota, N. (2006) A simple method of obtaining lingual mucosal cells with a toothbrush for DNA extraction. Oral Therap. Pharmacol. 25, 17-21
36. Imamura, Y., Katahira, T., and Kitamura, D. (2004) Identification and characterization of a novel BASH N terminus-associated protein, BNAS2. J. Biol. Chem. 279, 26425-26432 (Pubitemid 38798795)
37. Imamura, Y., Nakagawa, T., Iguchi-Ariga, S.M.M., and Ariga, H. (1993) Transcriptional regulation of the N-myc gene: identification of positive regulatory element and its double- and single-stranded DNA binding proteins. Biochim. Biophys. Acta 1216, 273-285
38. Sato, M., Azuma, M., Hayashi, Y., Yoshida, H., Yanagawa, T., and Yura, Y. (1987) 5-Azacytidine induction of stable myoepithelial and acinar cells from a human salivary intercalated duct cell clone. Cancer Res. 47, 4453-4459 (Pubitemid 17128149)
39. Ahmad, M., Piludu, M., Oppenheim, F.G., Helmerhorst, E.J., and Hand, A.R. (2004) Immunocytochemical localization of histatins in human salivary glands. J. Histochem. Cytochem. 52, 361-370
40. Royce, L.S., Kibbey, M.C., Mertz, P., Kleinman, H.K., and Baum, B.J. (1993) Human neoplastic submandibular intercalated duct cells express an acinar phenotype when cultured on a basement membrane matrix. Differentiation 52, 247-255 (Pubitemid 23096127)
41. Hoffman, M.P., Kibbey, M.C., Letterio, J.J., and Kleinman, H.K. (1996) Role of laminin-1 and TGF-β 3 in acinar differentiation of a human submandibular gland cell line (HSG). J. Cell Sci. 109, 2013-2021
42. Balducci-Silano, P.L., Suzuki, K., Ohta, M., Saito, J., Ohmori, M., Montani, V., Napolitano, G., Shong, M., Taniguchi, S.I., Pietrarelli, M., Lavaroni, S., Mori, A., Singer, D.S., and Kohn, L.D. (1998) Regulation of major histocompatibility (MHC) class II human leukocyte antigen-DR alpha gene expression in thyrocytes by single strand binding protein-1, a transcription factor that also regulates thyrotropin receptor and MHC class I gene expression. Endocrinology 139, 2300-2313 (Pubitemid 28513752)
43. Kimura, K., Saga, H., Hayashi, K., Obata, H., Chimori, Y., Ariga, H., and Sobue, K. (1998) c-Myc gene single-strand binding protein-1, MSSP-1, suppresses transcription α-smooth muscle actin gene in chicken visceral smooth muscle cells. Nucleic Acids Res. 26, 2420-2425 (Pubitemid 28297344)
44. Wu, L. (2006) Structure and function characterization of single-strand DNA binding protein SSDP1: carboxyl-terminal of SSDP1 has transcription activity. Biochem. Biophys. Res. Commun. 339, 977-984
45. Bai, G., Norton, D.D., Prenger, M.S., and Kusiak, J.W. (1998) Single-stranded DNA-binding proteins and neuron-restrictive silencer factor participate in cell-specific transcriptional control of the NMDAR1 gene. J. Biol. Chem. 273, 1086-1091
46. Dickinson, L.A. and Kohwi-Shigematsu, T. (1995) Nucleolin is a matrix attachment region DNA-binding protein that specifically recognizes a region with high base-unpairing potential. Mol. Cell Biol. 15, 456-465
47. Mitchell, P.J. and Tjian, R. (1989) Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science 245, 371-378 (Pubitemid 19203358)