Released ATP is an extracellular cytotoxic mediator in salivary histatin 5-induced killing of Candida albicans

Infection and Immunity

Volumn 68, Issue 12, 2000, Pages 6848-6856

  Koshlukova, Svetlana E ^a   Araujo, Marcelo W B ^a   Baev, Didi ^a   Edgerton, Mira ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTATIN;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CELL DEATH; CYTOTOXICITY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANAEROBIOSIS; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; HUMANS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; RECEPTORS, PURINERGIC P2; SALIVARY PROTEINS;

EID: 0034442695     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.12.6848-6856.2000     Document Type: Article

References (45)

1. Ansehn, S., and L. Nilsson. 1984. Direct membrane-damaging effect of ketoconazole and tioconazole on Candida albicans demonstrated by bioluminescent assay of ATP. Antimicrob. Agents Chemother. 26:22-25.
2. Boman, H. G. 1995. Peptide antibiotics and their role in innate immunity. Annu. Rev. Immunol. 13:61-92.
3. Boyum, B., and G. Guidotti. 1997. Glucose-dependent, cAMP-mediated ATP efflux from S. cerevisiae. Microbiology 143:1901-1908.
4. Burnstock, G. 1996. P2 purinoceptors: localization, function and transduction mechanisms. Ciba Found. Symp. 198:1-29.
5. Cannon, R. D., A. R. Holmes, A. B. Mason, and B. C. Monk. 1995. Oral candida: clearance, colonization or candidiasis? J. Dent. Res. 74:1152-1161.
6. Chessell, I. P., A. D. Simon, A. D. Hibell, A. D. Michel, E. A. Barnard, and P. P. A. Humphry. 1998. Cloning and functional characterisation of the mouse P2X7 receptor. FEBS Lett. 439:26-30.
7. Chowdhury, B., S. Bose, S. Bhaduri, and S. Bose. 1997. Isolation and properties of an ATP transporter from a strain of Aspergillus niger. Eur. J. Biochem. 247:673-680.
8. Chvatchko, Y., S. Valera, J. Aubry, T. Renno, G. Buell, and J. Bonnefoy. 1996. The involvement of an ATP-gated ion channel, P(2X1), in thymocyte apoptosis. Immunity 5:275-283.
9. Cockayne, A., and F. C. Odds. 1984. Interactions of Candida albicans yeast cells, germ tubes and hyphae with human polymorphonuclear leukocytes in vitro. J. Gen. Microbiol. 130:465-471.
10. Colman, R. 1990. Aggregin: a platelet ADP receptor that mediates activation. FASEB J. 4:1425-1435.
11. Di Virgilio, F. 1995. The P2Z purinoreceptor: an intriguing role in immunity, inflammation and cell death. Immunol. Today 16:524-528.
12. Di Virgilio, F., P. Chiozzi, S. Falzoni, D. Ferrari, J.M. Sanz, V. Venketaraman, and O. R. Baricordi. 1998. Cytolytic P2X purinoceptors. Cell Death Differ. 5:191-199.
13. Edgerton, M., S. E. Koshlukova, T. E. Lo, B. G. Chrzan, R. M. Straubinger, and P. A. Raj. 1998. Candidacidal activity of salivary histatins: identification of a histatin 5-binding protein on Candida albicans. J. Biol. Chem. 273: 20438-20447.
14. Ferrari, D., P. Chiozzi, S. Falzoni, M. DalSusino, G. Collo, G. Buell, and F. Di Virgilo. 1997. ATP-mediated cytotoxicity in microglial cells. Neuropharmacology 36:1295-1301.
15. Fredholm, B. B., M. P. Abbracchio, G. Burnstock, J. W. Daly, T. K. Harden, K. A. Jacobson, P. Leff, and M. Williams. 1994. Nomenclature and classification of purinoreceptors. Pharmacol. Rev. 46:143-156.
16. Guidotti, G. 1996. ATP transport and ABC proteins. Chem. Biol. 3:703-706.
17. Gyurko, C., U. Lendenmann, R. Troxler, and F. Oppenheim. 2000. Candida albicans mutants deficient in respiration are resistant to the small cationic salivary antimicrobial peptide histatin 5. Antimicrob. Agents Chemother. 44:348-354.
18. Hassett, R., A. Romeo, and D. Kosman. 1998. Regulation of high affinity iron uptake in yeast Saccharomyces cerevisiae. Role of dioxygen and Fe (II). J. Biol. Chem. 273:7628-7636.
19. Helmerhorst, E. J., P. Breeuwer, W. van 't Hof, E. Walgreen-Weterings, L. C. J. M. Oomen, E. C. I. Veerman, A. V. N. Amerongen, and T. Abee. 1999. The cellular target of histatin 5 on Candida albicans is the energized mitochondrion. J. Biol. Chem. 274:7286-7291.
20. Hill, C. P., J. Yee, M.E. Selsted, and D. A. Eisenberg. 1991. Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization. Science 251:1481-1485.
21. Hoffmann, J. A., F. C. Kafatos, C. A. Janeway, and R. A. B. Ezekowitz. 1999. Phylogenetic perspectives in innate immunity. Science 284:1313-1318.
22. Kagan, B. L., T. Ganz, and R. I. Lehrer. 1994. Defensins: a family of antimicrobial and cytotoxic peptides. Toxicology 87:131-149.
23. Koshlukova, S. E., T. L. Lloyd, M. W. B. Araujo, and M. Edgerton. 1999. Salivary histatin 5 induces non-lytic release of ATP from Candida albicans leading to cell death. J. Biol. Chem. 274:18872-18879.
24. Lieberthal, W., S. Menza, and J. Levine. 1998. Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells. Am. J. Physiol. 274:F315-F327.
25. 31P nuclear magnetic resonance study of the effect of azide on xylose fermentation by Candida tropicalis. Appl. Environ. Microbiol. 55:1974-1980.
26. Ludtke, S. J., K. He, W. T. Heller, T. A. Harroun, L. Yang, and H. W. Huang. 1996. Membrane pores induced by magainin. Biochemistry 35:13723-13728.
27. Noshiro, A., C. Rurwin, M. Laux, K. Nicolay, W. A. Scheffers, and H. Holzer. 1987. Mechanisms of stimulation of endogenous fermentation in yeast by carbonyl cyanide m-chlorophenylhydrazone. J. Biol. Chem. 262:14154-14157.
28. Odds, F. C. 1987. Candida infections: an overview. Crit. Rev. Microbiol. 15:1-5.
29. Olson, V., R. Hansing, and D. McClary. 1976. The role of metabolic energy in the lethal action of basic proteins on Candida albicans. Can. J. Microbiol. 23:166-174.
30. Oppenheim, F. G., T. Xu, F. McMillian, S. M. Levitz, R. D. Diamond, G. D. Offner, and R. F. Troxler. 1988. Histatins, a novel family of histidine-rich proteins in human parotid secretion. J. Biol. Chem. 263:7472-7477.
31. Prasad, R., P. Wergifosse, A. Goffeau, and E. Balzi. 1995. Molecular cloning and characterization of a novel gene of C. albicans. CDR1, conferring multiple resistance to drugs and antifungals. Curr. Genet. 27:320-329.
32. Raj, P. A., M. Edgerton, and M. J. Levine. 1990. Salivary histatin 5 - dependence of sequence, chain length and helical conformation for candidacidal activity. J. Biol. Chem. 265:3898-3905.
33. Raj, P. A., E. Marcus, and M. Edgerton. 1996. Delineation of an active fragment and poly(L-proline) II conformation for candidacidal activity of bactenecin 5. Biochemistry 35:4314-4325.
34. Raj, P. A., E. Marcus, and D. K. Sukumaran. 1998. Structure of human salivary histatin 5 in aqueous and nonaqueous solutions. Biopolymers 45:51-67.
35. Rassendren, F., G. Buell, C. Virginio, R. A. North, and A. Surprenant. 1997. The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA. J. Biol. Chem. 272:5482-5486.
36. Roman, R. M., Y. Wang, S. D. Lidofsky, A. P. Feranchak, N. Lomri, B. F. Scharschmidt, and J. G. Fitz. 1997. Hepatocellular ATP-binding cassette protein expression enhances ATP release and autocrine regulation of cell volume. J. Biol. Chem. 272:21970-21976.
37. Schlosser, S., A. Burgstahler, and M. Nathanson. 1996. Isolated rat hepatocytes can signal to other hepatocytes and bile duct cells by release of nucleotides. Proc. Natl. Acad. Sci. USA 93:9948-9953.
38. Schwiebert, E. M., M. E. Egan, T.-H. Hwang, S. B. Fulmer, S. S. Allen, G. R Cutting, and W. B. Guggino. 1995. CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP. Cell 81:1063-1073.
39. Serrano, R. 1977. Energy requirements for maltose transport in yeast. Eur. J. Biochem. 80:97-102.
40. 7). Science 272:735-738.
41. Todorov, L. D., S. Mihaylova-Todorora, T. D. Westfall, P. Sneddon, C. Kennedy, R. A. Bjur, and D. P. Westfall. 1997. Neuronal release of soluble nucleotidases and their role in neurotransmitter inactivation. Nature 387: 76-79.
42. Tsai, H., P. A. Raj, and L. A. Bobek. 1996. Candidacidal activity of recombinant salivary histatin-5 and variants. Infect. Immun. 64:5000-5007.
43. Wang, Y., R. Roman, S. D. Lidofsky, and J. G. Fitz. 1996. Autocrine signaling through ATP release represents a novel mechanism for cell volume regulation. Proc. Natl. Acad. Sci. USA 93:12020-12025.
44. Xu, T., S. M. Levitz, R. D. Diamond, and F. G. Oppenheim. 1991. Anticandidal activity of major salivary histatins. Infect. Immun. 59:2549-2554.
45. Xu, Y., I. Ambudkar, H. Yamagushi, W. Swam, T. Walsh, and B. O'Connell. 1999. Histatin 3-mediated killing of Candida albicans: effect of extracellular salt concentration on binding and internalization. Antimicrob. Agents and Chemother. 43:2256-2262.