Human salivary histatin-5 exerts potent fungicidal activity against Cryptococcus neoformans

Biochimica et Biophysica Acta - General Subjects

Volumn 1336, Issue 3, 1997, Pages 367-369

  Tsai, Hsiaoyun ^a   Bobek, Libuse A ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Antifungal agent; Fungal disease; Fungal pathogen; Histatin; HIV; Opportunistic infection; Yeast

Indexed keywords

HISTATIN; HISTATIN 5; UNCLASSIFIED DRUG;

CANDIDA ALBICANS; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; ESCHERICHIA COLI; FUNGICIDAL ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; SALIVA; SHORT SURVEY;

CANDIDA ALBICANS; ESCHERICHIA COLI; FILOBASIDIELLA NEOFORMANS;

EID: 0030670607     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4165(97)00076-7     Document Type: Article

References (10)

1. Oppenheim F.G., Xu T., McMillian F.M., Levitz S.M., Diamond R.D., Offner G.D., Troxler R.F. Histatins, a novel family of histidine-rich proteins in human parotid secretion. J. Biol. Chem. 263:1988;7472-7477.
2. Pollock J.J., Denepitiya L., Mackay B.J., Iacono V.J. Fungistatic and fungicidal activity of human parotid salivary histidine-rich polypeptides on Candida albicans. Infect. Immun. 44:1984;702-707.
3. Rayhan R., Xu L., SantarpiaIII R.P., Tylenda C.A., Pollock J.J. Antifungal activities of salivary histidine-rich polypeptides against Candida albicans and other oral yeast isolates. Oral Microbiol. Immunol. 7:1992;51-52.
4. Sabra R., Branch R.A. Amphotericin B nephrotoxicity. Drug Safety. 5:1990;94-108.
5. Goodman J.L., Winston D.J., Greenfield R.A., Chandrasekar P.H., Fox B., Kaizer H., Shadduck R.K., Shea T.C., Stiff P., Friedman D.J., Powderly W.G., Silber J.L., Horowitz H., Lichtin A., Wolff S.N., Mangan K.F., Silver S.M., Weisdorf D., Ho W.G., Gilbert G., Buell D. A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation. N. Engl. J. Med. 326:1992;845-851.
6. Mitchell T.G., Perfect J.R. Cryptococcosis in the era of AIDS-100 years after the discovery of Cryptococcus neoformans. Clin. Microb. Rev. 8:1995;515-548.
7. Raj P.A., Edgerton M., Levine M.J. Salivary Histatin-5: Dependence of sequence, chain length, and helical conformation for candidacidal activity. J. Biol. Chem. 265:1990;3898-3905.
8. H.Tsai, L.A. Bobek, Studies on the mechanism of human salivary histatin-5 cidal activity using histatin-5 variants and azole-sensitive and -resistant Candida species. Antimicrob. Agents Chemother. (1997) accepted.
9. Tsai H., Raj P.A., Bobek L.A. Candidacidal activity of recombinat human salivary histatin-5 and its mutants. Infect. Immun. 64:1996;5000-5007.
10. Driscoll J., Zuo Y., Xu T., Troxler R.F., Oppenheim F.G. Investigation of the anticandidal mechanism of histatins. J. Dent. Res. (abstr. 1751). 75:1996;358.