Human Salivary Histatin 5 Fungicidal Action Does Not Induce Programmed Cell Death Pathways in Candida albicans

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 1, 2004, Pages 110-115

  Wunder, David ^a   Dong, Jin ^a   Baev, Didi ^a   Edgerton, Mira ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CARBONYL DERIVATIVE; CYTOCHROME C; FUNGAL ENZYME; HISTATIN; HISTATIN 5; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANDIDA ALBICANS; CARBONYLATION; CELL DEATH; CELL LEVEL; CELL SURVIVAL; CHROMOSOME ANALYSIS; CONTROLLED STUDY; DRUG EFFECT; DRUG SENSITIVITY; FUNGAL CELL; FUNGICIDAL ACTIVITY; HUMAN; MITOCHONDRION; MUTANT; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; PROTEIN SECRETION; SACCHAROMYCES CEREVISIAE; SALIVA; WESTERN BLOTTING; WILD TYPE;

ANTIFUNGAL AGENTS; APOPTOSIS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CANDIDA ALBICANS; CHROMOSOMES, FUNGAL; CYTOCHROMES C; DNA, FUNGAL; FUNGAL PROTEINS; HUMANS; MICROBIAL SENSITIVITY TESTS; MITOCHONDRIA; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; SACCHAROMYCES CEREVISIAE; SALIVARY PROTEINS; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE;

EID: 0347992031     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.1.110-115.2004     Document Type: Article

References (44)

1. Aguilaniu, H., L. Gustafsson, M. Rigoulet, and T. Nystrom. 2001. Protein oxidation in Go cells of Saccharomyces cerevisiae depends on the state rather than rate of respiration and is enhanced in pos9 but not yap1 mutants. J. Biol. Chem. 276:35396-35404.
2. Baev, D., X. Li, and M. Edgerton. 2001. Genetically engineered human salivary histatin genes are functional in Candida albicans: development of a new system for studying histatin candidacidal activity. Microbiology 147: 3323-3334.
3. Baev, D., X. S. Li, J. Dong, P. Keng, and M. Edgerton. 2002. Human salivary histatin 5 causes disordered volume regulation and cell cycle arrest in Candida albicans. Infect. Immun. 70:4777-4784.
4. Cabiscol, E., E. Piulats, P. Echave, E. Herrero, and J. Ros. 2000. Oxidative stress promotes specific protein damage in Saccharomyces cerevisiae, J. Biol. Chem. 275:27393-27398.
5. Chang, E. C., B. F. Crawford, Z. Hong, T. Bilinski, and D. J. Kosman. 1991. Genetic and biochemical characterization of Cu,Zn superoxide dismutase mutants in Saccharomyces cerevisiae. J. Biol. Chem. 266:4417-4424.
6. Christin, L., D. R. Wysong, T. Meshulam, S. Wang, and R. D. Diamond. 1997. Mechanisms and target sites of damage in killing of Candida albicans hyphae by human polymorphonuclear neutrophils. J. Infect. Dis. 176: 1567-1578.
7. Coleman, D. C., D. E. Bennett, D. J. Sullivan, P. J. Gallagher, M. C. Henman, D. B. Shanley, and R. J. Russell. 1993. Oral Candida in HIV infection and AIDS: new perspectives/new approaches. Crit. Rev. Microbiol. 19:61-82.
8. Dumont, M. E., J. B. Schlichter, T. S. Cardillo, M. K. Hayes, G. Bethlendy, and F. Sherman. 1993. CYC2 encodes a factor involved in mitochondrial import of cytochrome c. Mol. Cell. Biol. 13: 6442-6451.
9. Edgerton, M., S. E. Koshlukova, T. E. Lo, B. G. Chrzan, R. M. Straubinger, and P. A. Raj. 1998. Candidacidal activity of salivary histatins: identification of a histatin 5-binding protein on Candida albicans. J. Biol. Chem. 273: 20438-20447.
10. Edgerton, M., and S. E. Koshlukova. 2000. Salivary histatin 5 and its similarities to the other antimicrobial proteins in human saliva. Adv. Dent. Res. 14:16-21.
11. Glick, P. A., and L. A. Pon. 1995. Isolation of highly purified mitochondria from Saccharomyces cerevisiae. Methods Enzymol. 260:213-223.
12. Greenspan, D. 1994. Treatment of oral candidiasis in HIV infection. Oral Surg. Oral Med. Oral Pathol. 78:211-215.
13. Helmerhorst, E. J., R. F. Troxler, and F. G. Oppenheim. 2001. The human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive oxygen species. Proc. Natl. Acad. Sci. USA 98:14637-14642.
14. Hwang, C. S., G. E. Rhie, J. H. Oh, W. K. Huh, H. S. Yim, and S. O. Kang. 2002. Copper- and zinc-containing superoxide dismutase (Cu/ZnSOD) is required for the protection of Candida albicans against oxidative stresses and the expression of its full virulence. Microbiology 148:3705-3713.
15. Hwang, C. S., G. Rhie, S. T. Kim, Y. R. Kim, W. K. Huh, Y. U. Baek, and S. O. Kang. 1999. Copper- and zinc-containing superoxide dismutase and its gene from Candida albicans. Biochim. Biophys. Acta 1427:245-255.
16. Janbon, G., F. Sherman, and E. Rustchenko. 1999. Appearance and properties of L-sorbose utilizing mutants of Candida albicans obtained on a selective plate. Genetics 153: 653-664.
17. Johnson, E. M., D. W. Warnock, J. Luker, S. R. Porter, and C. Scully. 1995. Emergence of azole drug resistance in Candida species from HIV-infected patients receiving prolonged fluconazole therapy for oral candidosis. J. Antimicrob. Chemother. 35:103-114.
18. Kobayashi, D., K. Kondo, N. Uehara, S. Otokozawa, N. Tsuji, A. Yagihashi, and N. Watanabe. 2002. Endogenous reactive oxygen species is an important mediator of miconazole antifungal effect. Antimicrob. Agents Chemother. 46:3113-3117.
19. Koshlukova, S. E., T. L. Lloyd, M. W. B. Araujo, and M. Edgerton. 1999. Salivary histatin 5 induces non-lytic release of ATP from Candida albicans leading to cell death. J. Biol. Chem. 274:18872-18879.
20. Kourie, J. I. 1998. Interaction of reactive oxygen species with ion transport mechanisms. Am. J. Physiol. 275:C1-C24.
21. Lamarre, C., J. D. LeMay, N. Deslauriers, and Y. Bourbonnais. 2001. Candida albicans expresses an unusual cytoplasmic manganese-containing superoxide dismutase (SOD3 gene product) upon the entry and during the stationary phase. J. Biol. Chem. 276:43784-43791.
22. Laun, P., A. Pichova, F. Madeo, J. Fuchs, A. Ellinger, S. Kohlwein, I. Dawes, K. U. Frohlich, and M. Breitenbach. 2001. Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis. Mol. Microbiol. 39:1166-1173.
23. 1 arrest in dioxygen stress in Saccharomyces cerevisiae. J. Biol. Chem. 271:24885-24893.
24. Lee, J. H., I. Y. Choi, I. S. Kil, S. Y. Kim, E. S. Yang, and J. W. Park. 2001. Protective role of superoxide dismutases against ionizing radiation in yeast. Biochim. Biophys. Acta 1526:191-198.
25. Levine, R. L., D. Garland, C. N. Oliver, A. Amici, I. Climent, A. G. Lenz, B. W. Ahn, S. Shaltiel, and E. R. Stadtman. 1990. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 186:464-478.
26. Levine, R. L., J. A. Williams, E. R. Stadtman, and E. Shacter. 1994. Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol. 233:346-357.
27. Ludovico, P., F. Rodrigues, A. Almeida, M. T. Silva, A. Barrientos, and M. Corte-Real. 2002. Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiae. Mol. Biol. Cell 13:2598-2606.
28. Madeo, F., E. Frohlich, and K. U. Frohlich. 1997. A yeast mutant showing diagnostic markers of early and late apoptosis. J. Cell Biol. 139:729-734.
29. Madeo, F., E. Frohlich, M. Ligr, M. Grey, S. J. Sigrist, D. H. Wolf, and K. U. Frohlich. 1999. Oxygen stress: a regulator of apoptosis in yeast. J. Cell Biol. 145:757-767.
30. Madeo, F., E. Herker, C. Maidener, S. Wissing, S. Lachelt, M. Herlan, M. Fehr, K. Lauber, S. J. Sigrist, S. Wesselborg, and K. U. Frohlich. 2002. A caspase-related protease regulates apoptosis in yeast. Mol. Cell 9:911-917.
31. Madeo, F., S. Engelhardt, E. Herker, N. Lehmann, C. Maldener, A. Proksch, S. Wissing, and K. U. Frohlich. 2002. Apoptosis in yeast: a new model system with applications in cell biology and medicine. Curr. Genet. 41:208-216.
32. Maeno, E., Y. Ishizaki, T. Kanaseki, A. Hazama, and Y. Okada. 2000. Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis. Proc. Natl. Acad. Sci. USA 97:9487-9492.
33. Oppenheim, F. G., T. Xu, F. M. McMillian, S. M. Levitz, R. D. Diamond, G. D. Offner, and R. F. Troxler. 1988. Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans. J. Biol. Chem. 263: 7472-7477.
34. Raj, P. A., M. Edgerton, and M. J. Levine. 1990. Salivary histatin 5: dependence of sequence, chain length, and helical conformation for candidacidal activity. J. Biol. Chem. 265:3898-3905.
35. Redding, S. W., R. C. Zellars, W. R. Kirkpatrick, R. K. McAtee, M. A. Caceres, A. W. Fothergill, J. L. Lopez-Ribot, C. W. Bailey, M. G. Rinaldi, and T. F. Patterson. 1999. Epidemiology of oropharyngeal Candida colonization and infection in patients receiving radiation for head and neck cancer. J. Clin. Microbiol. 37:3896-3900.
36. Rex, J. H., M. G. Rinaldi, and M. A. Pfaller. 1995. Resistance of Candida species to fluconazole. Antimicrob. Agents Chemother. 39:1-8.
37. Rhie, G. E., C. S. Hwang, M. J. Brady, S. T. Kim, Y. R. Kim, W. K. Huh, Y. U. Baek, B. H. Lee, J. S. Lee, and S. O. Kang. 1999. Manganese-containing superoxide dismutase and its gene from Candida albicans. Biochim. Biophys. Acta 1426:409-419.
38. Severin, F. F., and A. A. Hyman. 2002. Pheromone induces programmed cell death in S. cerevisiae. Curr. Biol. 12:R233-R235.
39. Troxler, R. F., G. D. Offner, T. Xu, J. C. Vanderspek, and F. G. Oppenheim. 1990. Structural relationship between salivary histatins. J. Dent. Res. 69:2-6.
40. Tsai, H., and L. A. Bobek. 1997. Human salivary histatin 5 exerts potent fungicidal activity against Cryotococcus neoformans. Biochim. Biophys. Acta 1336:367-369.
41. Tsai, H., and L. A. Bobek. 1997. Studies of the mechanism of human salivary histatin-5 candidacidal activity with histatin-5 variants and azole-sensitive and -resistant Candida species. Antimicrob. Agents Chemother. 41:2224-2228.
42. Xu, T., S. M. Levitz, R. D. Diamond, and F. G. Oppenheim. 1991. Anticandidal activity of major human salivary histatins. Infect. Immun. 59:2549-2554.
43. Xu, Y. Y., I. Ambudkar, H. Yamagishi, W. Swaim, T. J. Walsh, and B. C. O'Connell. 1999. Histatin 3-mediated killing of Candida albicans: effect of extracellular salt concentration on binding and internalization. Antimicrob. Agents Chemother. 43:2256-2262.
44. Zhou, X., W. Yin, S. Q. Doi, S. W. Robinson, K. Takeyasu, and X. Fan. 2003. Stimulation of Na, K-ATPase by low potassium requires reactive oxygen species. Am. J. Physiol. Cell Physiol. 285:C319-C326.