Nepalese traditional medicine and symptoms related to Parkinsons disease and other disorders: Patterns of the usage of plant resources along the Himalayan altitudinal range

Journal of Ethnopharmacology

Volumn 153, Issue 1, 2014, Pages 178-189

  De Rus Jacquet, Aurélie ^a   Subedi, Rupa ^b   Ghimire, Suresh K ^b   Rochet, Jean Christophe ^a  

^a PURDUE UNIVERSITY   (United States)

^b TRIBHUVAN UNIVERSITY   (Nepal)

Author keywords

Ayurvedic; Ethnopharmacology; Nepal; Neurodegenerative diseases; Parkinsons disease; Traditional medicine

Indexed keywords

HERBACEOUS AGENT; PLANT MEDICINAL PRODUCT;

ACACIA CATECHU; ACORUS CALAMUS; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPARAGUS RACEMOSUS; AYURVEDA; CENTELLA ASIATICA; CENTRAL NERVOUS SYSTEM DISEASE; COMPARATIVE EFFECTIVENESS; CONSENSUS; CULTURAL ANTHROPOLOGY; CULTURAL FACTOR; ENGELHARDIA SPICATA; ENVIRONMENTAL IMPACT; ETHNOPHARMACOLOGY; HUMAN; INTERVIEW; MEDICINAL PLANT; NEPAL; PARKINSON DISEASE; PLANT EVOLUTION; RUBUS ELLIPTICUS; SPECIES DIVERSITY; SWERTIA; SWERTIA CHIRAYITA; TRADITIONAL HEALER; TRADITIONAL MEDICINE; ALTITUDE; CHEMISTRY; ENVIRONMENTAL PROTECTION; PHYTOTHERAPY; PROCEDURES;

ALTITUDE; CONSERVATION OF NATURAL RESOURCES; CROSS-CULTURAL COMPARISON; ETHNOPHARMACOLOGY; HUMANS; MEDICINE, AYURVEDIC; MEDICINE, TRADITIONAL; NEPAL; PARKINSON DISEASE; PHYTOTHERAPY; PLANT PREPARATIONS; PLANTS, MEDICINAL;

EID: 84897004347     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.02.016     Document Type: Article

References (103)

1. A. Agarwal, S. Malini, K.L. Bairy, and M.S. Rao Effect of Tinospora cordifolia on learning and memory in normal and memory deficit rats Indian J. Pharmacol. 34 2002 339 349
2. K.L. Bairt, Y. Rao, and B. Kumar Efficacy of Tinospora cordifolia on learning and memory in healthy volunteers: a double-blind, randomized, placebo controlled study Iran. J. Pharmacol. Ther. 3 2004 57 60
3. S.B. Bajracharya, P.A. Furley, and A.C. Newton Impacts of community-based conservation on local communities in the Annapurna conservation area, Nepal Biodivers. Conserv. 15 2006 2765 2786
4. R. Banerjee, A.A. Starkov, M.F. Beal, and B. Thomas Mitochondrial dysfunction in the limelight of Parkinsons disease pathogenesis Biochim. Biophys. Acta 1792 2009 651 663
5. S. Banerjee, T.K. Sur, S. Mandal, P.C. Das, and S. Sikdar Assessment of the anti-inflammatory effects of Swertia chirata in acute and chronic experimental models in male albino rats Indian J. Pharmacol. 32 2000 21 24
6. R. Betarbet, T.B. Sherer, G. MacKenzie, M. Garcia-Osuna, A.V. Panov, and J.T. Greenamyre Chronic systemic pesticide exposure reproduces features of Parkinsons disease Nat. Neurosci. 3 2000 1301 1306
7. S.K. Bhattacharya, A. Bhattacharya, K. Sairam, and S. Ghosal Anxiolytic-Antidepressant activity of Withania somnifera glycowithanolides: an experimental study Phytomed. Int. J. Phytother. Phytopharmacol. 7 2000 463 469
8. S.K. Bhattacharya, and A.V. Muruganandam Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress Pharmacol. Biochem. Behav. 75 2003 547 555
9. S.K. Bhattacharya, P.K. Reddy, S. Ghosal, A.K. Singh, and P.V. Sharma Chemical constituents of Gentianaceae XIX: CNS-depressant effects of swertiamarin J. Pharm. Sci. 65 1976 1547 1549
10. K.R. Bhattarai, I.E. Maren, and R.P. Chaudhary Medicinal Plant Knowledge of the Panchase Region in the Middle Hills of the Nepalese Himalayas 2011 Banko Janakari 21.
11. K.R. Bhattarai, and O.R. Vetaas Variation in plant species richness of different life forms along a subtropical elevation gradient in the Himalayas, east Nepal Global Ecol. Biogeogr. 12 2003 327 340
12. K.K. Bhutani, A.T. Paul, W. Fayad, and S. Linder Apoptosis inducing activity of steroidal constituents from Solanum xanthocarpum and Asparagus racemosus Phytomed. Int. J. Phytother. Phytopharmacol. 17 2010 789 793
13. M.L. Block, L. Zecca, and J.S. Hong Microglia-mediated neurotoxicity: uncovering the molecular mechanisms Nat. Rev. Neurosci. 8 2007 57 69
14. J. Bradwejn, Y. Zhou, D. Koszycki, and J. Shlik A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects J. Clin. Psychopharmacol. 20 2000 680 684
15. N.S. Brown, and R. Bicknell Hypoxia and oxidative stress in breast cancer. Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer Breast Cancer Res. 3 2001 323 327
16. C.B. Carroll, P.G. Bain, L. Teare, X. Liu, C. Joint, C. Wroath, S.G. Parkin, P. Fox, D. Wright, J. Hobart, and J.P. Zajicek Cannabis for dyskinesia in Parkinson disease: a randomized double-blind crossover study Neurology 63 2004 1245 1250
17. P.C. Chen, M.R. Vargas, A.K. Pani, R.J. Smeyne, D.A. Johnson, Y.W. Kan, and J.A. Johnson Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinsons disease: critical role for the astrocyte Proc. Natl. Acad. Sci. U.S.A. 106 2009 2933 2938
18. C.M. Clements, R.S. McNally, B.J. Conti, T.W. Mak, and J.P. Ting DJ-1, a cancer- and Parkinsons disease-Associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2 Proc. Natl. Acad. Sci. U.S.A. 103 2006 15091 15096
19. S.P. Close, P.J. Elliott, A.G. Hayes, and A.S. Marriott Effects of classical and novel agents in a MPTP-induced reversible model of Parkinsons disease Psychopharmacology 102 1990 295 300
20. Y. Couch, L. Alvarez-Erviti, N.R. Sibson, M.J. Wood, and D.C. Anthony The acute inflammatory response to intranigral alpha-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation J. Neuroinflammation 8 2011 166
21. W. Dauer, and S. Przedborski Parkinsons disease: mechanisms and models Neuron 39 2003 889 909
22. T.M. Dawson, and V.L. Dawson Molecular pathways of neurodegeneration in Parkinsons disease Science 302 2003 819 822
23. T.M. Dawson, H.S. Ko, and V.L. Dawson Genetic animal models of Parkinsons disease Neuron 66 2010 646 661
24. M.J. Devine, H. Plun-Favreau, and N.W. Wood Parkinsons disease and cancer: two wars, one front Nat. Rev. Cancer 11 2011 812 823
25. D. Dhingra, and P.K. Goyal Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of Tinospora cordifolia in mice Indian J. Pharm. Sci. 70 2008 761 767
26. S. Diwanay, D. Chitre, and B. Patwardhan Immunoprotection by botanical drugs in cancer chemotherapy J. Ethnopharmacol. 90 2004 49 55
27. R.L. Doty Olfactory dysfunction in Parkinson disease. Nat. Rev. Neurol. 8 2012 329 339
28. DPR Medicinal Plants of Nepal. Department of Plant Resources (DPR) 2007 Ministry of Forest and Soil Conservation, Government of Nepal Thapathali, Kathmandu, Nepal.
29. M. Fort Geomorphic and hazards mapping in the dry, continental Himalaya - 1-50,000 maps of Mustang District, Nepal Mt. Res. Dev. 7 1987 222 238
30. D. Garcia, J. Leiro, R. Delgado, M.L. Sanmartin, and F.M. Ubeira Mangifera indica L. extract (Vimang) and mangiferin modulate mouse humoral immune responses Phytother. Res. 17 2003 1182 1187
31. M.B. Gewali S. Awale, Aspects of Traditional Medicine Nepal 2008 Institute of Natural Medicine, University of Toyama Japan.
32. S.K. Ghimire Medicinal Plants in the Nepal Himalaya: Current Issues, Sustainable Harvesting, Knowledge Gaps and Research Priorities, Medicinal Plants in Nepal: An Anthology of Contemporary Research 2008 Ecological Society (ECOS) Kathmandu, Nepal 25 42.
33. F.V. Gomes, E.A. Del Bel, and F.S. Guimaraes Cannabidiol attenuates catalepsy induced by distinct pharmacological mechanisms via 5-HT receptor activation in mice Prog. Neuro-psychopharmacol. Biol. Psychiatry 46C 2013 43 47
34. D.M. Gurfinkel, S. Chow, R. Hurren, M. Gronda, C. Henderson, C. Berube, D.W. Hedley, and A.D. Schimmer Disruption of the endoplasmic reticulum and increases in cytoplasmic calcium are early events in cell death induced by the natural triterpenoid Asiatic acid Apoptosis 11 2006 1463 1471
35. N. Haleagrahara, and K. Ponnusamy Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats J. Toxicol. Sci. 35 2010 41 47
36. H. Hörtnagl, and I. Hanin Toxins affecting the cholinergic system H. Herken, F. Hucho, Selective Neurotoxicity 1992 293 332
37. M.J. Howes, and P.J. Houghton Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function Pharmacol. Biochem. Behav. 75 2003 513 527
38. S.S. Huang, C.S. Chiu, H.J. Chen, W.C. Hou, M.J. Sheu, Y.C. Lin, P.H. Shie, and G.J. Huang Antinociceptive activities and the mechanisms of anti-inflammation of asiatic acid in mice Evid. Based Complement. Alternat. Med. 2011 1 10
39. IUCN, 2004. Protected Areas Programme. Durban World Parks Congress.
40. U. Jana, T.K. Sur, L.N. Maity, P.K. Debnath, and D. Bhattacharyya A clinical study on the management of generalized anxiety disorder with Centella asiatica Nepal Med. Coll. J. 12 2010 8 11
41. J. Jankovic, and W. Poewe Therapies in Parkinsons disease Curr. Opin. Neurol. 25 2012 433 447
42. C.P. Khare Indian Medicinal Plants: An Illustrated Dictionary 2007 Springer New York.
43. H. Kim, T.H. Han, and S.G. Lee Anti-inflammatory activity of a water extract of Acorus calamus L. leaves on keratinocyte HaCaT cells J. Ethnopharmacol. 122 2009 149 156
44. S.K. Kulkarni, and A. Dhir Withania somnifera: an Indian ginseng Prog. Neuro-psychopharmacol. Biol. Psychiatry 32 2008 1093 1105
45. Kunwar, R.M., Acharya R.P., 2013. Impact Assessment of Invasive Plant Species in Selected Ecosystems of Bhadaure Tamagi VDC, Kaski. An Ecosystem-based Adaptation in Mountain Ecosystem in Nepal. IUCN Nepal, Lalitpur, Nepal.
46. C. Kurbitz, D. Heise, T. Redmer, F. Goumas, A. Arlt, J. Lemke, G. Rimbach, H. Kalthoff, and A. Trauzold Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells Cancer Sci. 102 2011 728 734
47. W.J. Kwak, J.H. Kim, K.H. Ryu, Y.B. Cho, S.D. Jeon, and C.K. Moon Effects of gentianine on the production of pro-inflammatory cytokines in male Sprague-Dawley rats treated with lipopolysaccharide (LPS) Biol. Pharm. Bull. 28 2005 750 753
48. Lama, Y.C., Ghimire, S.K., Aumeeruddy-Thomas, Y., 2001. Medicinal Plants of Dolpo: Amchis knowledge and Conservation People and Plants Initiative. WWF Nepal Program, Kathmandu.
49. L. Liu, J. Wang, L. Shi, W. Zhang, X. Du, Z. Wang, and Y. Zhang beta-Asarone induces senescence in colorectal cancer cells by inducing lamin B1 expression Phytomed. Int. J. Phytother. Phytopharmacol. 20 2013 512 520
50. N.P. Manandhar Plants and People of Nepal 2002 Timber Press, Incorporated Portland Oregon, USA
51. J. Massano, and K.P. Bhatia Clinical approach to Parkinsons disease: features, diagnosis, and principles of management Cold Spring Harb. Perspect. Med. 2 2012 a008870
52. D.E. Moerman Agreement and meaning: rethinking consensus analysis J. Ethnopharmacol. 112 2007 451 460
53. MoFSC Nepal Biodiversity Strategy 2002 His Majestys Government of Nepal Kathmandu, Nepal 170 (p)
54. L.B. Moran, and M.B. Graeber Towards a pathway definition of Parkinsons disease: a complex disorder with links to cancer, diabetes and inflammation Neurogenetics 9 2008 1 13
55. K.R. Muller-Vahl, H. Kolbe, U. Schneider, and H.M. Emrich Cannabis in movement disorders Forschende Komplementarmedizin 6 Suppl. 3 1999 23 27
56. E. Murillo-Rodriguez, M. Palomero-Rivero, D. Millan-Aldaco, R. Mechoulam, and R. Drucker-Colin Effects on sleep and dopamine levels of microdialysis perfusion of cannabidiol into the lateral hypothalamus of rats Life Sci. 88 2011 504 511
57. R. Neupane, and S.D. Shrestha Hydrogeologic Assessment and Groundwater Reserve Evaluation in Northwestern Parts of Dun Valley Aquifers of Chitwan, Inner Terai 2009 Bulletin of the Department of Geology, Tribhuvan University Kathmandu, Nepal 43 54.
58. NTNC Sustainable Development Plan of Mustang (2008-2013) 2008 National Trust for Nature Conservation Nepal.
59. M.H. Oh, P.J. Houghton, W.K. Whang, and J.H. Cho Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity Phytomed. Int. J. Phytother. Phytopharmacol. 11 2004 544 548
60. R. Ojha, A.N. Sahu, A.V. Muruganandam, G.K. Singh, and S. Krishnamurthy Asparagus recemosus enhances memory and protects against amnesia in rodent models Brain Cogn. 74 2010 1 9
61. D. Pal, S. Sur, S. Mandal, A. Das, A. Roy, S. Das, and C.K. Panda Prevention of liver carcinogenesis by amarogentin through modulation of G(1)/S cell cycle check point and induction of apoptosis Carcinogenesis 33 2012 2424 2431
62. M.S. Parihar, and T. Hemnani Experimental excitotoxicity provokes oxidative damage in mice brain and attenuation by extract of Asparagus racemosus J. Neural Transm. 111 2004 1 12
63. B.C. Park, K.O. Bosire, E.S. Lee, Y.S. Lee, and J.A. Kim Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells Cancer Lett. 218 2005 81 90
64. B.C. Park, S.H. Paek, Y.S. Lee, S.J. Kim, E.S. Lee, H.G. Choi, C.S. Yong, and J.A. Kim Inhibitory effects of asiatic acid on 7,12-dimethylbenz[a] anthracene and 12-O-tetradecanoylphorbol 13-Acetate-induced tumor promotion in mice Biol. Pharm. Bull. 30 2007 176 179
65. E.K. Perry, and R.H. Perry Acetylcholine and hallucinations: disease-related compared to drug-induced alterations in human consciousness Brain Cogn. 28 1995 240 258
66. S. Phoboo, A. Devkota, and P.K. Jha Medicinal Plants in Nepal: An Anthology of Contemporary Research 2008 Ecological Society (ECOS) Kathmandu, Nepal 1 24
67. J.R. Press, K.K. Shrestha, and D.A. Sutton Annotated Checklist of the Flowering Plants of Nepal 2000 The Natural History Museum London.
68. L. Qin, X. Wu, M.L. Block, Y. Liu, G.R. Breese, J.S. Hong, D.J. Knapp, and F.T. Crews Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration Glia 55 2007 453 462
69. W. Qin, V. Haroutunian, P. Katsel, C.P. Cardozo, L. Ho, J.D. Buxbaum, and G.M. Pasinetti PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia Arch. Neurol. 66 2009 352 361
70. C.P. Ramsey, C.A. Glass, M.B. Montgomery, K.A. Lindl, G.P. Ritson, L.A. Chia, R.L. Hamilton, C.T. Chu, and K.L. Jordan-Sciutto Expression of Nrf2 in neurodegenerative diseases J. Neuropathol. Exp. Neurol. 66 2007 75 85
71. J.C. Rochet, B.A. Hay, and M. Guo Molecular insights into Parkinsons disease Prog. Mol. Biol. Transl. Sci. 107 2012 125 188
72. J. Rojas-Vera, A.V. Patel, and C.G. Dacke Relaxant activity of raspberry (Rubus idaeus) leaf extract in guinea-pig ileum in vitro Phytother. Res. 16 2002 665 668
73. V. Sanchez-Guajardo, C.J. Barnum, M.G. Tansey, and M. Romero-Ramos Neuroimmunological processes in Parkinsons disease and their relation to alpha-synuclein: microglia as the referee between neuronal processes and peripheral immunity ASN Neuro. 5 2013 113 139
74. L.H. Sanders, and J. Timothy Greenamyre Oxidative damage to macromolecules in human Parkinson disease and the rotenone model Free Radic. Biol. Med. 62 2013 111 120
75. N.P. Seeram, Y. Zhang, and M.G. Nair Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins Nutr. Cancer 46 2003 101 106
76. D. Shen, Q. Wu, M. Wang, Y. Yang, E.J. Lavoie, and J.E. Simon Determination of the predominant catechins in Acacia catechu by liquid chromatography/electrospray ionization-mass spectrometry J. Agric. Food Chem. 54 2006 3219 3224
77. P. Shengji Banking on Biodiversity: Report on the Regional Consultation on Biodiversity Assessment in the Hindu Kush-Himalayas: December 19-20 1996 International Centre for Integrated Mountain Development Kathmandu, Nepal 1995.
78. Y. Shirakami, M. Shimizu, and H. Moriwaki Cancer chemoprevention with green tea catechins: from bench to bed Curr. Drug Targets 13 2012 1842 1857
79. P.K. Shukla, V.K. Khanna, M.M. Ali, R.R. Maurya, S.S. Handa, and R.C. Srimal Protective effect of acorus calamus against acrylamide induced neurotoxicity Phytother. Res. 16 2002 256 260
80. J.M. Shulman, P.L. De Jager, and M.B. Feany Parkinsons disease: genetics and pathogenesis Annu. Rev. Pathol. 6 2011 193 222
81. T. Sidiq, A. Khajuria, P. Suden, S. Singh, N.K. Satti, K.A. Suri, V.K. Srinivas, E. Krishna, and R.K. Johri A novel sarsasapogenin glycoside from Asparagus racemosus elicits protective immune responses against HBsAg Immunol. Lett. 135 2011 129 135
82. A. Soumyanath, Y.P. Zhong, S.A. Gold, X. Yu, D.R. Koop, D. Bourdette, and B.G. Gold Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro J. Pharm. Pharmacol. 57 2005 1221 1229
83. M.G. Spillantini, M.L. Schmidt, V.M. Lee, J.Q. Trojanowski, R. Jakes, and M. Goedert Alpha-synuclein in Lewy bodies Nature 388 1997 839 840
84. J. St-Pierre, S. Drori, M. Uldry, J.M. Silvaggi, J. Rhee, S. Jager, C. Handschin, K. Zheng, J. Lin, W. Yang, D.K. Simon, R. Bachoo, and B.M. Spiegelman Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators Cell 127 2006 397 408
85. A. Subedi, R.P. Chaudhary, J.J. Vermeulen, and B. Gravendeel Panisea panchaseensis sp. nov (Orchidaceae) from central Nepal Nord. J. Bot. 29 2011 361 365
86. X.L. Tang, X.Y. Yang, H.J. Jung, S.Y. Kim, S.Y. Jung, D.Y. Choi, W.C. Park, and H. Park Asiatic acid induces colon cancer cell growth inhibition and apoptosis through mitochondrial death cascade Biol. Pharm. Bull. 32 2009 1399 1405
87. R. Tarawneh, and J.E. Galvin Potential future neuroprotective therapies for neurodegenerative disorders and stroke Clin. Geriatr. Med. 26 2010 125 147
88. R.T. Trotter, and M.H. Logan Informant Consensus: A New Approach for Identifying Potentially Effective Medicinal Plants, Plants in Indigenous Medicine & Diet: Biobehavioral Approaches 1986 Etkin N.L. Bedford Hills, NY 91 112
89. Upadhyay, M., 2012. Panchase Protected Forest: An Introduction. Panchase Protected Forest Program, Forestry Nepal.
90. I. Vandebroek The dual intracultural and intercultural relationship between medicinal plant knowledge and consensus Econ. Bot. 64 2010 303 317
91. K. Venderova, E. Ruzicka, V. Vorisek, and P. Visnovsky Survey on cannabis use in Parkinsons disease: subjective improvement of motor symptoms Mov. Disord. 19 2004 1102 1106
92. R.F. Villaran, A.M. Espinosa-Oliva, M. Sarmiento, R.M. De Pablos, S. Arguelles, M.J. Delgado-Cortes, V. Sobrino, N. Van Rooijen, J.L. Venero, A.J. Herrera, J. Cano, and A. Machado Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: potential risk factor in Parkinson's disease J. Neurochem. 114 2010 1687 1700
93. S.B. Vohora, S.A. Shah, and P.C. Dandiya Central nervous system studies on an ethanol extract of Acorus calamus rhizomes J. Ethnopharmacol. 28 1990 53 62
94. F. Wang, Z. Chang, Q. Fan, and L. Wang Epigallocatechin-3-gallate inhibits the proliferation and migration of human ovarian carcinoma cells by modulating p38 kinase and matrix metalloproteinase-2 Mol. Med. Rep. 9 2014 1085 1089
95. J.Y. Wang, L.L. Wen, Y.N. Huang, Y.T. Chen, and M.C. Ku Dual effects of antioxidants in neurodegeneration: direct neuroprotection against oxidative stress and indirect protection via suppression of glia-mediated inflammation Curr. Pharm. Des. 12 2006 3521 3533
96. A.B. West, V.L. Dawson, and T.M. Dawson To die or grow: Parkinsons disease and cancer Trends Neurosci. 28 2005 348 352
97. C.L. Xu, Q.Z. Wang, L.M. Sun, X.M. Li, J.M. Deng, L.F. Li, J. Zhang, R. Xu, and S.P. Ma Asiaticoside: attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax Pharmacol. Biochem. Behav. 100 2012 413 418
98. N. Yoshimi, K. Matsunaga, M. Katayama, Y. Yamada, T. Kuno, Z. Qiao, A. Hara, J. Yamahara, and H. Mori The inhibitory effects of mangiferin, a naturally occurring glucosylxanthone, in bowel carcinogenesis of male F344 rats Cancer Lett. 163 2001 163 170
99. R.J. Youle, and A.M. van der Bliek Mitochondrial fission, fusion, and stress Science 337 2012 1062 1065
100. Y. Zhang, and G.B. Gordon A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway Mol. Cancer Ther. 3 2004 885 893
101. B. Zheng, Z. Liao, J.J. Locascio, K.A. Lesniak, S.S. Roderick, M.L. Watt, A.C. Eklund, Y. Zhang-James, P.D. Kim, M.A. Hauser, E. Grunblatt, L.B. Moran, S.A. Mandel, P. Riederer, R.M. Miller, H.J. Federoff, U. Wullner, S. Papapetropoulos, M.B. Youdim, I. Cantuti-Castelvetri, A.B. Young, J.M. Vance, R.L. Davis, J.C. Hedreen, C.H. Adler, T.G. Beach, M.B. Graeber, F.A. Middleton, J.C. Rochet, and C.R. Scherzer PGC-1alpha, a potential therapeutic target for early intervention in Parkinsons disease Sci. Transl. Med. 2 2010 (52ra73)
102. X. Zou, S.L. Liu, J.Y. Zhou, J. Wu, B.F. Ling, and R.P. Wang Beta-Asarone induces LoVo colon cancer cell apoptosis by up-regulation of caspases through a mitochondrial pathway in vitro and in vivo Asian Pac. J. Cancer Prev. 13 2012 5291 5298
103. A.W. Zuardi, J.A. Crippa, J.E. Hallak, J.P. Pinto, M.H. Chagas, G.G. Rodrigues, S.M. Dursun, and V. Tumas Cannabidiol for the treatment of psychosis in Parkinsons disease J. Psychopharmacol. 23 2009 979 983