Effects on sleep and dopamine levels of microdialysis perfusion of cannabidiol into the lateral hypothalamus of rats

Life Sciences

Volumn 88, Issue 11-12, 2011, Pages 504-511

  Murillo Rodríguez, Eric ^a   Palomero Rivero, Marcela ^b   Millán Aldaco, Diana ^b   Mechoulam, Raphael ^c   Drucker Colín, René ^b  

^a Universidad del Mayab   (Mexico)

^b UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Cannabidiol; Dopamine; Lateral hypothalamus; Microdialysis; Wakefulness

Indexed keywords

CANNABIDIOL; DOPAMINE;

ALERTNESS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LEVEL; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; ELECTROENCEPHALOGRAM; ELECTROMYOGRAM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LATERAL HYPOTHALAMUS; MALE; MECHANICAL PROBE; MICRODIALYSIS; NONHUMAN; NUCLEUS ACCUMBENS; RAT; SLEEP; SLEEP DEPRIVATION; SLEEP REBOUND; SLEEP WAKING CYCLE;

ANIMALS; CANNABIDIOL; DOPAMINE; ELECTRODES, IMPLANTED; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; HYPOTHALAMUS; MALE; MICRODIALYSIS; NUCLEUS ACCUMBENS; PERFUSION; RATS; RATS, WISTAR; SLEEP; SLEEP DEPRIVATION;

CANNABIS SATIVA; RATTUS;

EID: 79952438369     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2011.01.013     Document Type: Article

References (54)

1. F.H. Alves, C.C. Crestani, F.V. Gomes, F.S. Guimarães, F.M. Correa, and L.B. Resstel Cannabidiol injected into the bed nucleus of the stria terminalis modulates baroreflex activity through 5-HT1A receptors Pharmacol Res 62 2010 228 236
2. O. Arias-Carrión, M. Stamelou, E. Murillo-Rodríguez, M. Menéndez-González, and E. Pöppel Dopaminergic reward system: a short integrative review Int Arch Med 6 2010 3 24
3. M. Asikainen, T. Deboer, T. Porkka-Heiskanen, D. Stenberg, and I. Tobler Sleep deprivation increases brain serotonin turnover in the Djungarian hamster Neurosci Lett 198 1995 21 24
4. J.A. Best, H.F. Nijhout, and M.C. Reed Homeostatic mechanisms in dopamine synthesis and release: a mathematical model Theor Biol Med Model 6 2009 21
5. J. Best, M. Reed, and H.F. Nijhout Models of dopaminergic and serotonergic signaling Pharmacopsychiatry 43 Suppl 1 2010 S61 S66
6. S. Bhattacharyya, P.D. Morrison, P. Fusar-Poli, R. Martin-Santos, S. Borgwardt, and T. Winton-Brown Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology Neuropsychopharmacology 3 2010 764 774
7. C. Blanco-Centurión, M. Xu, E. Murillo-Rodriguez, D. Gerashchenko, A.M. Shiromani, and R.J. Salin-Pascual Adenosine and sleep homeostasis in the Basal forebrain J Neurosci 26 2006 8092 8100 (Pubitemid 44315134)
8. A.A. Borbély, and P. Achermann Sleep homeostasis and models of sleep regulation M.H. Kryger, T. Roth, W.C. Dement, Principles and Practice of Sleep Medicine 4th ed. 2005 Elsevier/Saunders Philadelphia 405 417
9. A.C. Campos, and F.S. Guimarães Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats Psychopharmacology 199 2008 223 230
10. E.A. Carlini, and J.M. Cunha Hypnotic and antiepileptic effects of cannabidiol J Clin Pharmacol 21 Suppl. 8-9 1981 417S 427S
11. M. Danhof, G. Alvan, S.G. Dahl, J. Kuhlmann, and G. Paintaud Mechanism-based pharmacokinetic/pharmacodynamic modeling - a new classification of biomarkers Pharm Res 22 2005 1432 1437 (Pubitemid 41215882)
12. E.C. de Lang, P.G. Ravenstijn, D. Groenendaal, and T.J. van Steeg Toward the prediction of CNs drug-effect profiles in physiological and pathological conditions using MD and mechanism-based pharmacokinetic-pharmacodynamic modeling AAPS J 7 2005 E532 E543
13. F. Desarnaud, E. Murillo-Rodriguez, L. Lin, M. Xu, D. Gerashchenko, and S.N. Shiromani The diurnal rhythm of hypocretin in young and old F344 rats Sleep 27 2004 851 856 (Pubitemid 39095716)
14. J. Fadel, and A.Y. Deutch Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area Neuroscience 111 2002 379 387 (Pubitemid 34442621)
15. S.N. Haber, H.J. Groenewegen, E.A. Grove, and W.J. Nauta Efferent connections of the ventral pallidum: evidence of a dual striato pallidofugal pathway J Comp Neurol 235 1985 322 335 (Pubitemid 15041616)
16. B. Jones Arousal systems Front Biosci 8 2003 s438 s451
17. N.A. Jones, A.J. Hill, I. Smith, S.A. Bevan, C.M. Williams, and B.J. Whalley Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo J Pharmacol Exp Ther 332 2010 569 577
18. J. Kampe, M.H. Tschöp, J.H. Hollis, and B.J. Oldfield An anatomic basis for the communication of hypothalamic, cortical and mesolimbic circuitry in the regulation of energy balance Eur J Neurosci 30 2009 415 430
19. I. Léna, S. Parrot, O. Deschaux, S. Muffat-Joly, V. Sauvinet, and B. Renaud Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep-wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats J Neurosci Res 81 2005 891 899 (Pubitemid 41532155)
20. S. Leu-Semenescu, I. Arnulf, C. Decaix, F. Moussa, F. Clot, and C. Boniol Sleep and rhythm consequences of a genetically induced loss of serotonin Sleep 33 2010 307 314
21. Y. Li, J. Peris, L. Zhong, and H. Derendorf Microdialysis as a tool in local pharmacodynamics AAPS J 8 2006 E222 E235
22. R.R. Llinás, and M. Steriade Bursting of thalamic neurons and states of vigilance J Neurophysiol 95 2006 3297 3308 (Pubitemid 43846141)
23. J. Lu, T.C. Jhou, and C.B. Saper Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter J Neurosci 26 2006 193 202 (Pubitemid 43089532)
24. I. Magen, Y. Avraham, Z. Ackerman, L. Vorobiev, R. Mechoulam, and E.M. Berry Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation Br J Pharmacol 159 2010 950 957
25. R. Mechoulam, and L. Hanus Cannabidiol: an overview of some chemical and pharmacological aspects. Part I: chemical aspects Chem Phys Lipids 121 2002 35 43 (Pubitemid 36044540)
26. R. Mechoulam, M. Peters, E. Murillo-Rodríguez, and L.O. Hanus Cannabidiol - recent advances Chem Biodivers 4 2007 1678 1692 (Pubitemid 47377200)
27. E.Z. Millan, T.M. Furlong, and G.P. McNally Accumbens shell-hypothalamus interactions mediate extinction of alcohol seeking J Neurosci 30 2010 4626 4635
28. J.M. Monti Hypnotic-like effects of cannabidiol in the rat Psychopharmacology 3 1977 263 265
29. J.M. Monti, and D. Monti The involvement of dopamine in the modulation of sleep and waking Sleep Med Rev 11 2007 113 133 (Pubitemid 46330853)
30. E. Murillo-Rodríguez, C. Blanco-Centurión, D. Gerashchenko, R.J. Salín-Pascual, and P.J. Shiromani The diurnal rhythm of adenosine levels in the basal forebrain of young and old rats Neuroscience 123 2004 361 370 (Pubitemid 38032913)
31. E. Murillo-Rodríguez, D. Millán-Aldaco, M. Palomero-Rivero, R. Mechoulam, and R. Drucker-Colín Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats FEBS Lett 580 2006 4337 4345 (Pubitemid 44137348)
32. E. Murillo-Rodríguez, D. Millán-Aldaco, M. Palomero-Rivero, R. Mechoulam, and R. Drucker-Colín The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent Behav Neurosci 122 2008 1378 1382
33. E. Murillo-Rodríguez, O. Arias-Carrión, K. Sanguino-Rodríguez, M. González-Arias, and R. Haro Mechanisms of sleep-wake cycle modulation CNS Neurol Dis Drug Targets 8 2009 245 253
34. M. Narita, Y. Nagumo, S. Hashimoto, M. Narita, J. Khotib, and M. Miyatake Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine J Neurosci 26 2006 398 405 (Pubitemid 43237102)
35. A.N. Nicholson, C. Turner, B.M. Stone, and P.J. Robson Effect of delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults J Clin Psychopharmacol 24 2004 305 313 (Pubitemid 38658039)
36. Y.F. Pan, J. Feng, Q.Y. Cheng, and F.Z. Li Intracerebral microdialysis technique and its application on brain pharmacokinetic-pharmacodynamic study Arch Pharm Res 30 2007 1635 1645
37. G. Paxinos, and C. Watson The rat brain in stereotaxic coordinates fourth ed. 2005 Academic Press San Diego, CA
38. C. Peyron, D.K. Tighe, A.N. van den Pol, L. de Lecea, H.C. Heller, and J.G. Sutcliffe Neurons containing hypocretin (orexin) project to multiple neuronal systems J Neurosci 18 1998 9996 10015 (Pubitemid 28543775)
39. T. Porkka-Heiskanen, R.E. Strecker, and R.W. McCarley Brain site-specificity of extracellular adenosine concentration changes during sleep deprivation and spontaneous sleep: an in vivo microdialysis study Neuroscience 99 2000 507 517 (Pubitemid 30612453)
40. Y. Ren, J. Whittard, A. Higuera-Matas, C.V. Morris, and Y.L. Hurd Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances J Neurosci 29 2009 14764 14769
41. L.B. Resstel, R.F. Tavares, S.F. Lisboa, S.R. Joca, F.M. Corrêa, and F.S. Guimarães 5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats Br J Pharmacol 156 2009 181 188
42. E.B. Russo, G.W. Guy, and P.J. Robson Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine Chem Biodivers 4 2007 1729 1743 (Pubitemid 47377201)
43. C.B. Saper, T.C. Chou, and T.E. Scammell The sleep switch: hypothalamic control of sleep and wakefulness Trends Neurosci 24 2001 726 731 (Pubitemid 33097540)
44. P. Soares Vde, A.C. Campos, V.C. Bortoli, H. Zangrossi Jr., F.S. Guimarães, and A.W. Zuardi Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors Behav Brain Res 2 2010 225 229
45. M. Steriade, S. Datta, D. Paré, G. Oakson, and R.C. Curró Dossi Neuronal activities in brain-stem cholinergic nuclei related to tonic activation processes in thalamocortical systems J Neurosci 10 1990 2541 2559
46. N.V. Suntsova, and O.Y. Dergacheva Dynamics of neuron activity in the lateral preoptic area of the hypothalamus during the sleep-waking cycle Neurosci Behav Physiol 33 2003 651 658 (Pubitemid 37160473)
47. N.V. Suntsova, O.Y. Dergacheva, and A.A. Burikov The role of the posterior hypothalamus in controlling the paradoxical phase of sleep Neurosci Behav Physiol 30 2000 161 167 (Pubitemid 30410161)
48. R. Szymusiak, N. Alam, T.L. Steininger, and D. McGinty Sleep-waking discharge patterns of ventrolateral preoptic/anterior hypothalamic neurons in rats Brain Res 803 1998 178 188 (Pubitemid 28392144)
49. N. Taepavarapruk, P. Taepavarapruk, J. John, Y.Y. Lai, J.M. Siegel, and A.G. Phillips State-dependent changes in glutamate, glycine, GABA, and dopamine levels in cat lumbar spinal cord J Neurophysiol 100 2008 598 608
50. M.M. Thakkar, V. Ramesh, R.E. Strecker, and R.W. McCarley Microdialysis perfusion of orexin-A in the basal forebrain increases wakefulness in freely behaving rats Arch Ital Biol 139 2001 313 328 (Pubitemid 32274943)
51. J.P. Wisor, S. Nishino, I. Sora, G.H. Uhl, E. Mignot, and D.M. Edgar Dopaminergic role in stimulant-induced wakefulness J Neurosci 21 2001 1787 1794 (Pubitemid 32184295)
52. D.S. Zahm, and L. Heimer Specificity in the efferent projections of the nucleus accumbens in the rat: comparison of the rostral pole projection patterns with those of the core and shell J Comp Neurol 327 1993 220 232 (Pubitemid 23019812)
53. T.V. Zanelati, C. Biojone, F.A. Moreira, F.S. Guimarães, and S.R. Joca Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors Br J Pharmacol 1 2010 122 128
54. A.W. Zuardi Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action Rev Bras Psiquiatr 30 2008 271 280