Effects of gentianine on the production of pro-inflammatory cytokines in male Sprague-Dawley rats treated with lipopolysaccharide (LPS)

Biological and Pharmaceutical Bulletin

Volumn 28, Issue 4, 2005, Pages 750-753

  Kwak, Wie Jong ^a,b   Kim, Joo Hyon ^a   Ryu, Keun Ho ^a   Cho, Yong Baik ^a   Jeon, Sun Duck ^a   Moon, Chang Kiu ^b  

^a SK Chemicals   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Anti inflammatory mechanism; Gentianine; Interleukin (IL) 6; Lipopolysacharide (LPS); Tumor necrosis factor (TNF)

Indexed keywords

ANTIINFLAMMATORY AGENT; CYTOKINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GENTIANINE; INTERLEUKIN 6; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENTIAN; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE; INFLAMMATION; MALE; NONHUMAN; NORMAL HUMAN; RAT;

ADULT; ALKALOIDS; ANIMALS; ANTI-INFLAMMATORY AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 21144433116     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.28.750     Document Type: Article

References (23)

1. Johji Y., Takao K., Tokunosuke S., Hajime F., Yakugaku Zasshi, 98, 1446-1451 (1978).
2. Wan A. S. C., Macko E., Douglas B., Asian J. Med., 8, 334-335 (1972).
3. Butler D. M., Malfait A. M., Mason L. J., Warden P. J., Kollias G., Maini R. N., Feldmann M., Brennan F. M., J. Immunol., 159, 2867-2876 (1997).
4. Mease P. J., Goffe B. S., Metz J., VanderStoep A., Finck B., Burge D. J., Lancet, 356, 385-390 (2000).
5. Tracey K. J., "The Cytokine Handbook," 2nd ed., Academic Press, New York, 1996.
6. Asherson R. A., Pascoe L., Ann. Rheum. Dis., 61, 859-860 (2002).
7. Reiff A., Takei S., Sadeqhi S., Arthritis Rheum., 44, 1411-1415 (2001).
8. Hamblin A. S., "Textbook of Immunopharmacology," 3rd ed., Blackwell Scientific Publications, Oxford, 1994.
9. Govindachari T. R., Nagarajan K., Rajappa S., J. Chem. Soc., 2725-2726 (1957).
10. Douni E., Akassoglou K., Alexopoulou L., Georgopoulos S., Haralambous S., Hill S., Kassiotis G., Kontoyiannis D., Pasparakis M., Plows D., Probert L., Kollias G., J. Inflamm., 47, 27-38 (1995).
11. Huang R. P., J. Immunol. Methods, 255, 1-13 (2001).
12. Bencsics A., Elenkov I. J., Vizi E. S., J. Neuroimmunol., 73, 1-6 (1997).
13. Douni E., Kollias G., J. Exp. Med., 188, 1343-1352 (1998).
14. Alexopoulou L., Pasparakis M., Kollias G., Eur. J. Immunol., 27, 2588-2592 (1997).
15. Beutler B., J. Invest. Med., 43, 227-235 (1995).
16. Elenkov I. J., Hasko G., Kovacs K. J., Vizi E. S., J. Neuroimmunol., 61, 123-131 (1995).
17. Erroi A., Fantuzzi G., Mengozzi M., Sironi M., Orencole S. F., Clark B. D., Dinarello C. A., Isetta A., Gnocchi P., Giovarelli M., Infect. Immun., 61, 4356-4359 (1993).
18. O'Brien-Ladner A. R., Blumer B. M., Wesselius L. J., J. Lab. Clin. Med., 132, 497-506 (1988).
19. Meldrum D. R., Meng X., Sheridan B. C., McIntyre R. C., Jr., Harken A. H., Banerjee A., Shock, 9, 256-260 (1998).
20. Targan S. R., Hanauer S. B., van Deventer S. J., Mayer L., Present D. H., Braakman T., DeWoody K. L., Schaible T. F., Rutgeerts P. J., N. Eng. J. Med., 337, 1029-1035 (1997).
21. Moncada S., Palmer R. M., Higgs D. A., Pharmacol. Rev., 43, 109-142 (1992).
22. Zukerman S. H., Shellhaas J., Butler L. D., Eur. J. Immunol., 12, 301-305 (1989).
23. Sands B. E., Tremaine W. J., Sandborn W. J., Rutgeerts P. J., Hanauer S. B., Mayer L., Targan S. R., Podolsky D. K., Inflamm. Bowel Dis., 7, 83-88 (2001).