Relaxant activity of raspberry (Rubus idaeus) leaf extract in guinea-pig ileum in vitro

Phytotherapy Research

Volumn 16, Issue 7, 2002, Pages 665-668

  Rojas Vera, Janne ^a,b   Patel, Asmita V ^a   Dacke, Christopher G ^a  

^a UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^b UNIVERSIDAD DE LOS ANDES   (Venezuela)

Author keywords

Guinea pig ileum; Myorelaxant; Pharmacological activity; Rosaceae; Rubus idaeus

Indexed keywords

ACETIC ACID ETHYL ESTER; CHLOROFORM; HEXANE; METHANOL; PLANT EXTRACT; RUBUS IDAEUS EXTRACT; SILICA GEL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; COLIC; DOSE RESPONSE; DRUG EFFECT; GUINEA PIG; ILEUM; NONHUMAN; PLANT LEAF; RASPBERRY; SMOOTH MUSCLE RELAXATION; THIN LAYER CHROMATOGRAPHY; TRADITIONAL MEDICINE; UTERUS RELAXATION; WOUND CARE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; ILEUM; INHIBITORY CONCENTRATION 50; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; ROSACEAE;

CAVIA PORCELLUS; ROSACEAE; RUBUS; RUBUS GLAUCUS; RUBUS IDAEUS; SUS SCROFA;

EID: 0036846569     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1040     Document Type: Article

References (21)

1. Abysique A, Lucchini S, Orsoni P, Mei N, Bouvier M. 1999. Effects of alverine critrate on cat intestinal mechano-receptor responses to chemical and medicinal stimuli. Aliment Pharmacol Ther 13: 561-566.
2. Beckett A, Belthle F, Fell K, Lock M. 1954. The active constituents of raspberry leaves. J Pharm Pharmacol 6: 785-796.
3. Bhakumi R. 1987. Chemical examination of the roots of Rubus ellipticus. Indian Drugs 24: 272.
4. Burn J, Camb M, Withell E. 1941. A principle in raspberry leaves which relaxes uterine muscle. Lancet 6149-6151.
5. Castleman M. 1991. The Healing Herbs. The Ultimate Guide to the Curative Power of Nature's Medicines. Rodale Press: Pennsylvania, 294-296.
6. Chou W, Oinaka T, Kanamaru F, Mizutani K, Chen F, Tanaka O. 1987. Diterpene glycosides from leaves of Chinese Rubus chingii and fruits of Rubus suavissimus and identification of the source plant of the Chinese folk medicine fu-pen-zi. Chem Pharm Bull 35: 3021-3024.
7. Gupta S. 1979. Chemical investigation of the leaves of Rubus moluccanus Linn (Rosaceae). J Indian Chem Soc 56:323-324.
8. Kitchen I. 1984. Textbook of In Vitro Practical Pharmacology. Butler & Tanner Ltd, Blackwell: Oxford, 153.
9. Lis-Balchin M, Hart S. 1999. Studies on the mode of action of peppermint oil Mentha x piperita L. in the guinea-pig ileum in vitro. Med Sci Res 27: 307-309.
10. Maga J, Squire C, Hughes H. 1992. Bramble dried leaf volatiles. Food Sci Hum Nut 29: 145-148.
11. Makhlouf G. 1994. Neuromuscular function of the small intestine. In Physiology of the Gastrointestinal Tract, Johnson L (ed), 3rd edn, Volume 1. Raven Press: New York 977-990.
12. Mingsheng L. 1994. Chemical constituents of Rubus plants. J Shenyan Col Pharm 11: 68-72.
13. Newall C. 1996. Herbal Medicines. A Guide for Healthcare Professionals. Pharmaceutical Press: London, 226.
14. 1 from Rubus imperialis. J Nat Prod 62: 1145-1146.
15. Nogueira E, Rosa G, Vassilief V. 1998. Involvement of GABA α-benzodiazepine receptor in the anxiolytic effect induced by hexanic fraction of Rubus brasiliensis. J Ethnopharmacol 61: 119-126.
16. Ody P. 1993. The Complete Medicinal Herbal. Dorling Kindersley: London, 170-171.
17. Patel A, Obiyan J, Patel N, Dacke C. 1995. Raspberry leaf extract relaxes intestinal smooth muscle in vitro. J Pharm Pharmacol 47: 1129.
18. Pattee P, Thompson W. 1992. Drug treatment of the irritable bowel syndrome. Drugs 44: 200-206.
19. Richards R, Durham D, Liu X. 1994. Antibacterial activity of compounds from Rubus pifaensis. Planta Med 60: 471-473.
20. Shepherd T, Robertson G, Griffiths D, Birch A. 1999. Epicuticular wax ester and triacylglycerol composition in relation to aphid infestation and resistance in red raspberry (Rubus idaeus). Phytochemistry 52: 1255-1267.
21. Zhou W. 1992. A new sweet diterpene-glucoside in leaves of Rubus suavissimus. Acta Bot Sinica 34: 315-318.