Asiaticoside: Attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax

Pharmacology Biochemistry and Behavior

Volumn 100, Issue 3, 2012, Pages 413-418

  Xu, Chang Liang ^a   Wang, Qi Zhi ^b   Sun, Ling Mei ^c   Li, Xiu Min ^a   Deng, Ji Min ^a   Li, Lu Fan ^a   Zhang, Jin ^a   Xu, Rong ^d   Ma, Shi Ping ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b INSTITUTE OF BOTANY   (China)

^c NORTHEASTERN UNIVERSITY   (United States)

^d NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Asiaticoside; Bcl 2 Bax ratio; Neuroprotection; Parkinson's disease; Redox

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ASIATICOSIDE; DOPAMINE; GLUTATHIONE; MALONALDEHYDE; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CENTELLA ASIATICA; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; DOSE RESPONSE; DRUG ISOLATION; DRUG MEGADOSE; GENE EXPRESSION; LIPID PEROXIDATION; LOCOMOTION; MALE; MOTOR COORDINATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OPEN FIELD TEST; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PARKINSONISM; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA; UPREGULATION;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; ANTIOXIDANTS; BCL-2-ASSOCIATED X PROTEIN; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; GENE EXPRESSION REGULATION; GLUTATHIONE; LIPID PEROXIDATION; MALE; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; OXIDATION-REDUCTION; PARKINSONIAN DISORDERS; PROTO-ONCOGENE PROTEINS C-BCL-2; RANDOM ALLOCATION; RATS; RATS, WISTAR; RNA, MESSENGER; SUBSTANTIA NIGRA; TRITERPENES;

CENTELLA ASIATICA; RATTUS;

EID: 80054860012     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2011.09.014     Document Type: Article

References (29)

1. Z.I. Alam, S.E. Daniel, A.J. Lees, D.C. Marsden, P. Jenner, and B. Halliwell A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease J Neurochem 69 1997 1326 1329 (Pubitemid 27364859)
2. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248 254
3. G. Del-Poeta, A. Venditti, M.I. Del-Principe, L. Maurillo, F. Buccisano, and A. Tamburini Amount of spontaneous apoptosis detected by bax/bcl-2 ratio predicts outcome in acute myeloid leukemia (AML) Blood 101 2003 2125 2131 (Pubitemid 36302046)
4. D.T. Dexter, C.J. Carter, F.R. Wells, F. Javoy-Agid, Y. Agid, and A. Lees Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease J Neurochem 52 1989 381 389 (Pubitemid 19037600)
5. M. Dhanasekaran, L.A. Holcomb, A.R. Hitt, B. Tharakan, J.W. Porter, and K.A. Young Centella asiatica extract selectively decreases amyloid beta levels in hippocampus of Alzheimer's disease animal model Phytother Res 23 2009 14 19
6. H. Esterbauer, R.J. Schaur, and H. Zollner Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes Free Radic Biol Med 11 1991 81 128 (Pubitemid 121003917)
7. T.N. Ferraro, G.T. Golden, M. DeMattei, T.A. Hare, and R.G. Fariello Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on levels of glutathione in the extrapyramidal system of the mouse Neuropharmacology 25 1986 1071 1074 (Pubitemid 16050472)
8. M.M. Ferro, M.I. Bellissimo, J.A. Anselmo-Franci, M.E. Angellucci, N.S. Canteras, and C. Da Cunha Comparison of bilaterally 6-OHDA- and MPTP-lesioned rats as models of the early phase of Parkinson's disease: histological, neurochemical, motor and memory alterations J Neurosci Methods 148 2005 78 87 (Pubitemid 41423461)
9. S.J. Flora, and R. Gupta Beneficial effects of Centella asiatica aqueous extract against arsenic-induced oxidative stress and essential metal status in rats Phytother Res 21 2007 980 988 (Pubitemid 47582774)
10. A. Gross, J.M. McDonnell, and S.J. Korsmeyer BCL-2 family members and the mitochondria in apoptosis Genes Dev 13 1999 1899 1911 (Pubitemid 29407357)
11. J. Gutierrez, S.W. Ballinger, V.M. Darley-Usmar, and A. Landar Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells Circ Res 99 2006 924 932 (Pubitemid 44657795)
12. N. Haleagrahara, and K. Ponnusamy Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced Parkinsonism in aged Sprague-Dawley rats J Toxicol Sci 35 2010 41 47
13. D.M. Hockenbery, Z.N. Oltvai, X.M. Yin, C.L. Milliman, and S.J. Korsmeyer Bcl-2 functions in an antioxidant pathway to prevent apoptosis Cell 75 1993 241 251 (Pubitemid 23320288)
14. D.J. Kane, T.A. Sarafian, R. Anton, H. Hahn, E.B. Gralla, and J.S. Valentine Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species Science 262 1993 1274 1277 (Pubitemid 24036095)
15. J.W. Langston, P. Ballard, J.W. Tetrud, and I. Irwin Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis Science 219 1983 979 980 (Pubitemid 13189531)
16. X.M. Li, C.L. Xu, J.M. Deng, L.F. Li, S.P. Ma, and R. Qu Protective effect of Zhen-Wu-Tang (ZWT) through keeping DA stable and VMAT 2/DAT mRNA in balance in rats with striatal lesions induced by MPTP J Ethnopharmacol 134 2011 768 774
17. L.P. Liang, J. Huang, R. Fulton, B.J. Day, and M. Patel An orally active catalytic metalloporphyrin protects against 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity in vivo J Neurosci 27 2007 4326 4333 (Pubitemid 46640723)
18. W. Mandemakers, V.A. Morais, and B. De Strooper A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases J Cell Sci 120 2007 1707 1716 (Pubitemid 46930408)
19. A. Meister, and M.E. Anderson Glutathione Annu Rev Biochem 52 1983 711 760 (Pubitemid 13030692)
20. N. Mirkovic, D.W. Voehringer, M.D. Story, D.J. McConkey, T.J. McDonnell, and R.E. Meyn Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols Oncogene 15 1997 1461 1470 (Pubitemid 27437836)
21. I. Mook-Jung, J.E. Shin, S.H. Yun, K. Huh, J.Y. Koh, and H.K. Park Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity J Neurosci Res 58 1999 417 425 (Pubitemid 29508575)
22. T. Nagatsu, and M. Sawada Inflammatory process in Parkinson's disease: role for cytokines Curr Pharm Des 11 2005 999 1016 (Pubitemid 40331301)
23. N. Nanashima, M. Akita, T. Yamada, T. Shimizu, H. Nakano, and Y. Fan The hairless phenotype of the Hirosaki hairless rat is due to the deletion of an 80-kb genomic DNA containing five basic keratin genes J Biol Chem 283 2008 16868 16875
24. D.J. Reed, and M.K. Savage Influence of metabolic inhibitors on mitochondrial permeability transition and glutathione status Biochim Biophys Acta 1271 1995 43 50
25. L.M. Sayre, M.A. Smith, and G. Perry Chemistry and biochemistry of oxidative stress in neurodegenerative disease Curr Med Chem 8 2001 721 738 (Pubitemid 32427903)
26. L. Yang, R.T. Matthews, J.B. Schulz, T. Klockgether, A.W. Liao, and J.C. Martinou 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2 J Neurosci 18 1998 8145 8152 (Pubitemid 28464993)
27. K.J. Yun, J.Y. Kim, J.B. Kim, K.W. Lee, S.Y. Jeong, and H.J. Park Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-kappa B inactivation in RAW 264.7 macrophages: possible involvement of the IKK and MAPK pathways Int Immunopharmacol 8 2008 431 441
28. L. Zhang, H.Z. Li, X. Gong, F.L. Luo, B. Wang, and N. Hu Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide/d- galactosamine in mice Phytomedicine 17 2010 811 819
29. L.J. Zhou, and X.Z. Zhu Reactive oxygen species-induced apoptosis in PC12 cells and protective effect of bilobalide J Pharmacol Exp Ther 293 2000 982 988 (Pubitemid 30417867)