Polycationic nanoparticles for siRNA delivery: Comparing ARGET ATRP and UV-initiated formulations

ACS Nano

Volumn 8, Issue 3, 2014, Pages 2908-2917

  Forbes, Diane C ^a   Peppas, Nicholas A ^a,b  

^a The University of Texas at Austin   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

ARGET ATRP; cationic polymer; drug delivery; siRNA; UV initiated

Indexed keywords

BIOCOMPATIBILITY; CELL CULTURE; CROSSLINKING; DRUG DELIVERY; MONOMERS; NANOPARTICLES; POLYACRYLATES; POLYETHYLENE GLYCOLS; RNA;

ARGET ATRP; CATIONIC POLYMERS; HUMAN EMBRYONIC KIDNEY CELLS; NANOPARTICLE FORMULATION; POLY(ETHYLENE GLYCOL) METHYL ETHER METHACRYLATE (PEG-MMA); SIRNA; SMALL INTERFERING RNA (SIRNA); UV-INITIATED;

SYNTHESIS (CHEMICAL);

DRUG CARRIER; NANOPARTICLE; POLYAMINE; POLYCATIONS; SMALL INTERFERING RNA;

ANIMAL; ARTICLE; CHEMISTRY; COMPARATIVE STUDY; ELECTRON TRANSPORT; FLOW CYTOMETRY; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HUMAN; MEDICINAL CHEMISTRY; METABOLISM; MOUSE; POLYMERIZATION; TRANSPORT AT THE CELLULAR LEVEL; ULTRAVIOLET RADIATION;

ANIMALS; BIOLOGICAL TRANSPORT; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; ELECTRON TRANSPORT; FLOW CYTOMETRY; HEK293 CELLS; HUMANS; MICE; NANOPARTICLES; POLYAMINES; POLYMERIZATION; RNA, SMALL INTERFERING; TRANSFECTION; ULTRAVIOLET RAYS;

EID: 84896992911     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn500101c     Document Type: Article

References (35)

1. Bouchie, A. Companies in Footrace To Deliver RNAi Nat. Biotechnol. 2012, 30, 1154-1157
2. Kang, H. C.; Huh, K. M.; Bae, Y. H. Polymeric Nucleic Acid Carriers: Current Issues and Novel Design Approaches J. Controlled Release 2012, 164, 256-264
3. Kriegel, C.; Attarwala, H.; Amiji, M. Multi-compartmental Oral Delivery Systems for Nucleic Acid Therapy in the Gastrointestinal Tract Adv. Drug Delivery Rev. 2013, 65, 891-901
4. Rehman, Z.; Zuhorn, I. S.; Hoekstra, D. How Cationic Lipids Transfer Nucleic Acids into Cells and across Cellular Membranes: Recent Advances J. Controlled Release 2013, 166, 46-56
5. Forbes, D. C.; Peppas, N. A. Oral Delivery of Small RNA and DNA J. Controlled Release 2012, 162, 438-445
6. Cejka, D.; Losert, D.; Wacheck, V. Short Interfering RNA (siRNA): Tool or Therapeutic? Clin. Sci. 2006, 110, 47
7. Singh, S.; Narang, A. S.; Mahato, R. I. Subcellular Fate and Off-Target Effects of siRNA, shRNA, and miRNA Pharm. Res. 2011, 28, 2996-3015
8. Lindow, M.; Vornlocher, H.; Riley, D.; Kornbrust, D. J.; Burchard, J.; Whiteley, L. O.; Kamens, J.; Thompson, J. D.; Nochur, S.; Younis, H. et al. Assessing Unintended Hybridization-Induced Biological Effects of Oligonucleotides Nat. Biotechnol. 2012, 30, 920-923
9. Soutschek, J.; Akinc, A.; Bramlage, B.; Charisse, K.; Constien, R.; Donoghue, M.; Elbashir, S.; Geick, A.; Hadwiger, P.; Harborth, J. et al. Therapeutic Silencing of an Endogenous Gene by Systemic Administration of Modified siRNAs Nature 2004, 432, 173-178
10. Bartlett, D. W.; Davis, M. E. Effect of siRNA Nuclease Stability on the In Vitr o and In Vivo Kinetics of siRNA-Mediated Gene Silencing Biotechnol. Bioeng. 2007, 97, 909-921
11. Dykxhoorn, D. M.; Palliser, D.; Lieberman, J. The Silent Treatment: siRNAs as Small Molecule Drugs Gene Ther. 2006, 13, 541-552
12. Whitehead, K. A.; Langer, R.; Anderson, D. G. Knocking Down Barriers: Advances in siRNA Delivery Nat. Rev. Drug Discovery 2009, 8, 129-138
13. Marine, S.; Freeman, J.; Riccio, A.; Axenborg, M.; Pihl, J.; Ketteler, R.; Aspengren, S. High-Throughput Transfection of Differentiated Primary Neurons from Rat Forebrain J. Biomol. Screening 2012, 17, 692-696
14. Bertram, B.; Wiese, S.; von Holst, A. High-Efficiency Transfection and Survival Rates of Embryonic and Adult Mouse Neural Stem Cells Achieved by Electroporation J. Neurosci. Methods 2012, 209, 420-427
15. Carralot, J.; Kim, T.; Lenseigne, B.; Boese, A. S.; Sommer, P.; Genovesio, A.; Brodin, P. Automated High-Throughput siRNA Transfection in Raw 264.7 Macrophages: A Case Study for Optimization Procedure J. Biomol. Screening 2009, 14, 151-160
16. Forbes, D. C.; Creixell, M.; Frizzell, H.; Peppas, N. A. Polycationic Nanoparticles Synthesized Using ARGET ATRP for Drug Delivery Eur. J. Pharm. Biopharm. 2013, 84, 472-478
17. Forbes, D. C.; Peppas, N. A. Differences in Molecular Structure in Cross-Linked Polycationic Nanoparticles Synthesized Using ARGET ATRP or UV-Initiated Polymerization Polymer 2013, 54, 4486-4492
18. Fisher, O. Z.; Kim, T.; Dietz, S. R.; Peppas, N. A. Enhanced Core Hydrophobicity, Functionalization and Cell Penetration of Polybasic Nanomatrices Pharm. Res. 2008, 26, 51-60
19. Fisher, O. Z.; Peppas, N. A. Polybasic Nanomatrices Prepared by UV-Initiated Photopolymerization Macromolecules 2009, 42, 3391-3398
20. Santel, A.; Aleku, M.; Keil, O.; Endruschat, J.; Esche, V.; Fisch, G.; Dames, S.; Löffler, K.; Fechtner, M.; Arnold, W. et al. A Novel siRNA-Lipoplex Technology for RNA Interference in the Mouse Vascular Endothelium Gene Ther. 2006, 13, 1222-1234
21. Petrova, N. S.; Chernikov, I. V.; Meschaninova, M. I.; Dovydenko, I. S.; Venyaminova, A. G.; Zenkova, M. A.; Vlassov, V. V.; Chernolovskaya, E. L. Carrier-Free Cellular Uptake and the Gene-Silencing Activity of the Lipophilic siRNAs Is Strongly Affected by the Length of the Linker between siRNA and Lipophilic Group Nucleic Acids Res. 2012, 40, 2330-2344
22. Qi, L.; Gao, X. Quantum Dot-Amphipol Nanocomplex for Intracellular Delivery and Real-Time Imaging of siRNA ACS Nano 2008, 2, 1403-1410
23. Zoldan, J.; Lytton-Jean, A. K. R.; Karagiannis, E. D.; Deiorio-Haggar, K.; Bellan, L. M.; Langer, R.; Anderson, D. G. Directing Human Embryonic Stem Cell Differentiation by Non-viral Delivery of siRNA in 3D Culture Biomaterials 2011, 32, 7793-7800
24. Liechty, W. B.; Scheuerle, R. L.; Peppas, N. A. Tunable, Responsive Nanogels Containing t -Butyl Methacrylate and 2-(t -Butylamino)ethyl Methacrylate Polymer 2013, 54, 3784-3795
25. Ghosn, B.; Kasturi, S. P.; Roy, K. Enhancing Polysaccharide-Mediated Delivery of Nucleic Acids through Functionalization with Secondary and Tertiary Amines Curr. Top. Med. Chem. 2008, 8, 331-340
26. Singh, A.; Nie, H.; Ghosn, B.; Qin, H.; Kwak, L. W.; Roy, K. Efficient Modulation of T-Cell Response by Dual-Mode, Single-Carrier Delivery of Cytokine-Targeted siRNA and DNA Vaccine to Antigen-Presenting Cells Mol. Ther. 2008, 16, 2011-2021
27. Sun, T.-M.; Du, J.-Z.; Yan, L.-F.; Mao, H.-Q.; Wang, J. Self-Assembled Biodegradable Micellar Nanoparticles of Amphiphilic and Cationic Block Copolymer for siRNA Delivery Biomaterials 2008, 29, 4348-4355
28. Charlaftis, N.; Fearon, D. T.; Schoenemeyer, A.; Morley, P. J. siRNA High-Throughput Kinase Library Screen Identifies Protein Kinase, DNA-Activated Catalytic Polypeptide To Play a Role in MyD88-Induced IFNA2 Activation and IL-8 Secretion Biotechnol. Appl. Biochem. 2012, 59, 6-14
29. Chen, M.; Cooper, H. M.; Zhou, J. Z.; Bartlett, P. F.; Xu, Z. P. Reduction in the Size of Layered Double Hydroxide Nanoparticles Enhances the Efficiency of siRNA Delivery J. Colloid Interface Sci. 2013, 390, 275-281
30. Kim, S.; Ye, C.; Kumar, P.; Chiu, I.; Subramanya, S.; Wu, H.; Shankar, P.; Manjunath, N. Targeted Delivery of siRNA to Macrophages for Anti-inflammatory Treatment Mol. Ther. 2010, 18, 993-1001
31. Wilson, D. S.; Dalmasso, G.; Wang, L.; Sitaraman, S. V.; Merlin, D.; Murthy, N. Orally Delivered Thioketal Nanoparticles Loaded with TNF-α siRNA Target Inflammation and Inhibit Gene Expression in the Intestines Nat. Mater. 2010, 9, 923-928
32. Laroui, H.; Theiss, A. L.; Yan, Y.; Dalmasso, G.; Nguyen, H. T. T.; Sitaraman, S. V.; Merlin, D. Functional TNFα Gene Silencing Mediated by Polyethyleneimine/TNFα siRNA Nanocomplexes in Inflamed Colon Biomaterials 2011, 32, 1218-1228
33. He, C.; Yin, L.; Tang, C.; Yin, C. Multifunctional Polymeric Nanoparticles for Oral Delivery of TNF-alpha siRNA to Macrophages Biomaterials 2013, 34, 2843-2854
34. McCarthy, J.; O'Neill, M.; Bourre, L.; Walsh, D.; Quinlan, A.; Hurley, G.; Ogier, J.; Shanahan, F.; Melgar, S.; Darcy, R. et al. Gene Silencing of TNF-alpha in a Murine Model of Acute Colitis Using a Modified Cyclodextrin Delivery System J. Controlled Release 2013, 168, 28-34
35. Shrestha, R.; Elsabahy, M.; Florez-Malaver, S.; Samarajeewa, S.; Wooley, K. L. Endosomal Escape and siRNA Delivery with Cationic Shell Crosslinked Knedel-like Nanoparticles with Tunable Buffering Capacities Biomaterials 2012, 33, 8557-8568