Assessing unintended hybridization-induced biological effects of oligonucleotides

Nature Biotechnology

Volumn 30, Issue 10, 2012, Pages 920-923

  Lindow, Morten ^a   Vornlocher, Hans Peter ^b   Riley, Donald ^c   Kornbrust, Douglas J ^d   Burchard, Julja ^e   Whiteley, Laurence O ^f   Kamens, Joanne ^g   Thompson, James D ^h   Nochur, Saraswathy ⁱ   Younis, Husam ^j   Bartz, Steven ^e   Parry, Joel ^k   Ferrari, Nicolay ^l   Henry, Scott P ^j   Levin, Arthur A ^m  

^a Santaris Pharma AS   (Denmark)

^b AXOLABS GMBH   (Germany)

^c DNA Consulting LLC   (United States)

^d Preclinsight   (United States)

^e MERCK RESEARCH LABORATORIES   (United States)

^f PFIZER INC   (United States)

^g RXi   (United States)

^h QBI Enterprises Ltd   (Israel)

ⁱ ALNYLAM PHARMACEUTICALS   (United States)

^j ISIS PHARMACEUTICALS   (United States)

^k GLAXOSMITHKLINE   (United Kingdom)

^l Topigen Pharmaceuticals Pharmaxis Ltd   (Canada)

^m MiRagen Therapeutics   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MICRORNA; OLIGONUCLEOTIDE; SMALL INTERFERING RNA;

COMPUTER MODEL; DRUG EFFECT; HUMAN; HYBRIDIZATION; LETTER; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGONUCLEOTIDE THERAPY; PRIORITY JOURNAL; RNA SEQUENCE;

COMPUTATIONAL BIOLOGY; DRUG DISCOVERY; HUMANS; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDES;

EID: 84867346804     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.2376     Document Type: Letter

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