PI3Kγ kinase activity is required for optimal T-cell activation and differentiation

European Journal of Immunology

Volumn 43, Issue 12, 2013, Pages 3183-3196

  Ladygina, Nadia ^a   Gottipati, Sridevi ^a   Ngo, Karen ^a   Castro, Glenda ^a   Ma, Jing Ying ^a   Banie, Homayon ^a   Rao, Tadimeti S ^a   Fung Leung, Wai Ping ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Cell activation; Cell differentiation; Immune responses; PI3K gamma; T cells

Indexed keywords

INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PROTEIN KINASE B; ANTIGEN; ENZYME INHIBITOR; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PIK3CG PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; ENZYME ACTIVITY; IMMUNE RESPONSE; IMMUNIZATION; LIPID RAFT; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MEMORY T LYMPHOCYTE; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL; TH2 CELL; ANIMAL; AUTOIMMUNE DISEASE; BAGG ALBINO MOUSE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL MEMBRANE; DRUG ANTAGONISM; GENETICS; HELPER CELL; IMMUNE RESPONSES; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; PATHOLOGY; PHOSPHORYLATION; PI3K GAMMA; TRANSGENIC MOUSE; T CELLS;

CELL ACTIVATION; CELL DIFFERENTIATION; IMMUNE RESPONSES; PI3K GAMMA; T CELLS;

ANIMALS; ANTIGENS; AUTOIMMUNE DISEASES; CELL DIFFERENTIATION; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; ENZYME INHIBITORS; HYPERSENSITIVITY, DELAYED; LYMPHOCYTE ACTIVATION; MEMBRANE MICRODOMAINS; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84896982280     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201343812     Document Type: Article

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