Genetic ablation of PI3Kγ results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels

European Journal of Immunology

Volumn 42, Issue 12, 2012, Pages 3394-3404

  Harris, Stephanie J ^a   Ciuclan, Loredana ^b   Finan, Peter M ^b   Wymann, Matthias P ^c   Walker, Christoph ^b   Westwick, John ^b   Ward, Stephen G ^a   Thomas, Matthew J ^b  

^a University of Bath   (United Kingdom)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

IL 17; PI3K ; T lymphocytes

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; INTERLEUKIN 17RA; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PROTEIN KINASE B; RECOMBINANT INTERLEUKIN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STIMULUS RESPONSE; T LYMPHOCYTE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INTERLEUKIN-17; LUNG; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, INTERLEUKIN-17; SIGNAL TRANSDUCTION;

EID: 84871303467     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201242463     Document Type: Article

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