Blockade of phosphatidylinositol 3-kinase (PI3K)δ or PI3Kγ reduces IL-17 and ameliorates imiquimod-induced psoriasis-like dermatitis

Journal of Immunology

Volumn 189, Issue 9, 2012, Pages 4612-4620

  Roller, Anne ^a   Perino, Alessia ^b   Dapavo, Paolo ^b   Soro, Elisabetta ^b   Okkenhaug, Klaus ^c   Hirsch, Emilio ^b   Ji, Hong ^a  

^a MERCK SERONO S A   (Switzerland)

^b UNIVERSITY OF TURIN   (Italy)

^c BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 (6 AMINO 9 PURINYLMETHYL) 5 METHYL 3 (2 METHYLPHENYL) 3H QUINAZOLIN 4 ONE; 5 (6 QUINOXALINYLMETHYLENE) 2,4 THIAZOLIDINEDIONE; AS 614006; CALCIPOTRIOL; CHEMOKINE RECEPTOR CCR6; DISEASE MODIFYING ANTIRHEUMATIC DRUG; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMIQUIMOD; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; PETROLATUM; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE DELTA; PHOSPHATIDYLINOSITOL 3 KINASE DELTA INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ACANTHOSIS; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOTAXIS; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; GAMMA DELTA T LYMPHOCYTE; GENE TARGETING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; KNOCKOUT MOUSE; LYMPH NODE; MALE; MOUSE; NONHUMAN; PARAKERATOSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SYNTHESIS INHIBITION; PSORIASIS; SKIN DEFECT; T LYMPHOCYTE ACTIVATION;

AMINOQUINOLINES; ANIMALS; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; DERMATITIS; DISEASE MODELS, ANIMAL; FEMALE; GENE KNOCK-IN TECHNIQUES; HUMANS; INTERLEUKIN-17; LYMPH NODES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; PHOSPHATIDYLINOSITOL 3-KINASES; PSORIASIS; T-LYMPHOCYTE SUBSETS;

EID: 84867907486     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1103173     Document Type: Article

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