Intracellular glutathione depletion by oridonin leads to apoptosis in hepatic stellate cells

Molecules

Volumn 19, Issue 3, 2014, Pages 3327-3344

  Kuo, Liang Mou ^a,b   Kuo, Chan Yen ^c   Lin, Chen Yu ^c   Hung, Min Fa ^c   Shen, Jiann Jong ^c   Hwang, Tsong Long ^c  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Glutathione; Hepatic Stellate Cells; Oridonin; Reactive Oxygen Species

Indexed keywords

CASPASE 3; GLUTATHIONE; KAURANE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; ORIDONIN; REACTIVE OXYGEN METABOLITE;

ANIMAL; APOPTOSIS; ARTICLE; CELL LINE; CELL SURVIVAL; DRUG EFFECT; ENZYME ACTIVATION; IC 50; INTRACELLULAR SPACE; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PHOSPHORYLATION; RAT; STELLATE CELL;

ANIMALS; APOPTOSIS; CASPASE 3; CELL LINE; CELL SURVIVAL; DITERPENES, KAURANE; ENZYME ACTIVATION; GLUTATHIONE; HEPATIC STELLATE CELLS; INHIBITORY CONCENTRATION 50; INTRACELLULAR SPACE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOGEN-ACTIVATED PROTEIN KINASES; OXIDATIVE STRESS; PHOSPHORYLATION; RATS; REACTIVE OXYGEN SPECIES;

EID: 84896980251     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules19033327     Document Type: Article

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