-
1
-
-
33750288398
-
A pilot study in patients with established advanced liver fibrosis using pirfenidone
-
Armendáriz-Borunda J, Islas-Carbajal MC, Meza-García E, Rincón AR, Lucano S, Sandoval AS, Salazar A, Berumen J, Alvarez A, Covarrubias A, Aréchiga G, García L. A pilot study in patients with established advanced liver fibrosis using pirfenidone. Gut 55: 1663-1665, 2006.
-
(2006)
Gut
, vol.55
, pp. 1663-1665
-
-
Armendáriz-Borunda, J.1
Islas-Carbajal, M.C.2
Meza-García, E.3
Rincón, A.R.4
Lucano, S.5
Sandoval, A.S.6
Salazar, A.7
Berumen, J.8
Alvarez, A.9
Covarrubias, A.10
Aréchiga, G.11
García, L.12
-
2
-
-
70349756901
-
Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C
-
Colmenero J, Bataller R, Sancho-Bru P, Domínguez M, Moreno M, Forns X, Bruguera M, Arroyo V, Brenner DA, Ginès P. Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol 297: G726-G734, 2009.
-
(2009)
Am J Physiol Gastrointest Liver Physiol
, vol.297
-
-
Colmenero, J.1
Bataller, R.2
Sancho-Bru, P.3
Domínguez, M.4
Moreno, M.5
Forns, X.6
Bruguera, M.7
Arroyo, V.8
Brenner, D.A.9
Ginès, P.10
-
3
-
-
41649096578
-
Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury
-
Douglass A, Wallace K, Parr R, Park J, Durward E, Broadbent I, Barelle C, Porter AJ, Wright MC. Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury. J Hepatol 49: 88-98, 2008.
-
(2008)
J Hepatol
, vol.49
, pp. 88-98
-
-
Douglass, A.1
Wallace, K.2
Parr, R.3
Park, J.4
Durward, E.5
Broadbent, I.6
Barelle, C.7
Porter, A.J.8
Wright, M.C.9
-
4
-
-
13744255589
-
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
-
Duffield JS, Forbes SJ, Constandinou CM, Clay S, Partolina M, Vuthoori S, Wu S, Lang R, Iredale JP. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest 115: 56-65, 2005.
-
(2005)
J Clin Invest
, vol.115
, pp. 56-65
-
-
Duffield, J.S.1
Forbes, S.J.2
Constandinou, C.M.3
Clay, S.4
Partolina, M.5
Vuthoori, S.6
Wu, S.7
Lang, R.8
Iredale, J.P.9
-
5
-
-
73549089485
-
Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts
-
Fickert P, Fuchsbichler A, Moustafa T, Wagner M, Zollner G, Halilbasic E, Stöger U, Arrese M, Pizarro M, Solís N, Carrasco G, Caligiuri A, Sombetzki M, Reisinger E, Tsybrovskyy O, Zatloukal K, Denk H, Jaeschke H, Pinzani M, Trauner M. Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts. Am J Pathol 175: 2392-2405, 2009.
-
(2009)
Am J Pathol
, vol.175
, pp. 2392-2405
-
-
Fickert, P.1
Fuchsbichler, A.2
Moustafa, T.3
Wagner, M.4
Zollner, G.5
Halilbasic, E.6
Stöger, U.7
Arrese, M.8
Pizarro, M.9
Solís, N.10
Carrasco, G.11
Caligiuri, A.12
Sombetzki, M.13
Reisinger, E.14
Tsybrovskyy, O.15
Zatloukal, K.16
Denk, H.17
Jaeschke, H.18
Pinzani, M.19
Trauner, M.20
more..
-
6
-
-
34548301514
-
A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C
-
Huang H, Shiffman ML, Friedman S, Venkatesh R, Bzowej N, Abar OT, Rowland CM, Catanese JJ, Leong DU, Sninsky JJ, Layden TJ, Wright TL, White T, Cheung RC. A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C. Hepatology 46: 297-306, 2007.
-
(2007)
Hepatology
, vol.46
, pp. 297-306
-
-
Huang, H.1
Shiffman, M.L.2
Friedman, S.3
Venkatesh, R.4
Bzowej, N.5
Abar, O.T.6
Rowland, C.M.7
Catanese, J.J.8
Leong, D.U.9
Sninsky, J.J.10
Layden, T.J.11
Wright, T.L.12
White, T.13
Cheung, R.C.14
-
7
-
-
33847363203
-
Models of liver fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ
-
Iredale JP. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest 117: 539-548, 2007.
-
(2007)
J Clin Invest
, vol.117
, pp. 539-548
-
-
Iredale, J.P.1
-
8
-
-
33745484285
-
Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats
-
Leclercq IA, Sempoux C, Stärkel P, Horsmans Y. Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats. Gut 55: 1020-1029, 2006.
-
(2006)
Gut
, vol.55
, pp. 1020-1029
-
-
Leclercq, I.A.1
Sempoux, C.2
Stärkel, P.3
Horsmans, Y.4
-
9
-
-
33646893689
-
Identifying off-target effects and hidden phenotypes of drugs in human cells
-
MacDonald ML, Lamerdin J, Owens S, Keon BH, Bilter GK, Shang Z, Huang Z, Yu H, Dias J, Minami T, Michnick SW, Westwick JK. Identifying off-target effects and hidden phenotypes of drugs in human cells. Nat Chem Biol 2: 329-337, 2006.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 329-337
-
-
McDonald, M.L.1
Lamerdin, J.2
Owens, S.3
Keon, B.H.4
Bilter, G.K.5
Shang, Z.6
Huang, Z.7
Yu, H.8
Dias, J.9
Minami, T.10
Michnick, S.W.11
Westwick, J.K.12
-
10
-
-
77950201652
-
Farglitazar lacks antifibrotic activity in patients with chronic hepatitis C infection
-
Farglitizar Study Investigators
-
McHutchison J, Goodman Z, Patel K, Makhlouf H, Rodriguez-Torres M, Shiffman M, Rockey D, Husa P, Chuang WL, Levine R, Jonas M, Theodore D, Brigandi R, Webster A, Schultz M, Watson H, Stancil B, Gardner S; Farglitizar Study Investigators. Farglitazar lacks antifibrotic activity in patients with chronic hepatitis C infection. Gastroenterology 138: 1365-1373, 2010.
-
(2010)
Gastroenterology
, vol.138
, pp. 1365-1373
-
-
McHutchison, J.1
Goodman, Z.2
Patel, K.3
Makhlouf, H.4
Rodriguez-Torres, M.5
Shiffman, M.6
Rockey, D.7
Husa, P.8
Chuang, W.L.9
Levine, R.10
Jonas, M.11
Theodore, D.12
Brigandi, R.13
Webster, A.14
Schultz, M.15
Watson, H.16
Stancil, B.17
Gardner, S.18
-
11
-
-
77950608186
-
Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats
-
Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K, Brenner DA, Ginès P, Bataller R. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Hepatology 51: 942-952, 2010.
-
(2010)
Hepatology
, vol.51
, pp. 942-952
-
-
Moreno, M.1
Gonzalo, T.2
Kok, R.J.3
Sancho-Bru, P.4
van Beuge, M.5
Swart, J.6
Prakash, J.7
Temming, K.8
Fondevila, C.9
Beljaars, L.10
Lacombe, M.11
van der Hoeven, P.12
Arroyo, V.13
Poelstra, K.14
Brenner, D.A.15
Ginès, P.16
Bataller, R.17
-
12
-
-
38749134463
-
Regression of fibrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic rats
-
Muñoz-Luque J, Ros J, Fernández-Varo G, Tugues S, Morales-Ruiz M, Alvarez CE, Friedman SL, Arroyo V, Jiménez W. Regression of fibrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic rats. J Pharmacol Exp Ther 324: 475-483, 2008.
-
(2008)
J Pharmacol Exp Ther
, vol.324
, pp. 475-483
-
-
Muñoz-Luque, J.1
Ros, J.2
Fernández-Varo, G.3
Tugues, S.4
Morales-Ruiz, M.5
Alvarez, C.E.6
Friedman, S.L.7
Arroyo, V.8
Jiménez, W.9
-
13
-
-
28844504265
-
Histological-hemodynamic correlation in cirrhosis-a histological classification of the severity of cirrhosis
-
Nagula S, Jain D, Groszmann RJ, Garcia-Tsao G. Histological-hemodynamic correlation in cirrhosis-a histological classification of the severity of cirrhosis. J Hepatol 44: 111-117, 2006.
-
(2006)
J Hepatol
, vol.44
, pp. 111-117
-
-
Nagula, S.1
Jain, D.2
Groszmann, R.J.3
Garcia-Tsao, G.4
-
14
-
-
11144325650
-
Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis
-
Oakley F, Meso M, Iredale JP, Green K, Marek CJ, Zhou X, May MJ, Millward-Sadler H, Wright MC, Mann DA. Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. Gastroenterology 128: 108-120, 2005.
-
(2005)
Gastroenterology
, vol.128
, pp. 108-120
-
-
Oakley, F.1
Meso, M.2
Iredale, J.P.3
Green, K.4
Marek, C.J.5
Zhou, X.6
May, M.J.7
Millward-Sadler, H.8
Wright, M.C.9
Mann, D.A.10
-
15
-
-
66149104271
-
Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis
-
Oakley F, Teoh V, Ching A, Sue G, Bataller R, Colmenero J, Jonsson JR, Eliopoulos AG, Watson MR, Manas D, Mann DA. Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis. Gastroenterology 136: 2334-2344, 2009.
-
(2009)
Gastroenterology
, vol.136
, pp. 2334-2344
-
-
Oakley, F.1
Teoh, V.2
Ching, A.3
Sue, G.4
Bataller, R.5
Colmenero, J.6
Jonsson, J.R.7
Eliopoulos, A.G.8
Watson, M.R.9
Manas, D.10
Mann, D.A.11
-
16
-
-
33744956853
-
Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB
-
Popov Y, Patsenker E, Bauer M, Niedobitek E, Schulze-Krebs A, Schuppan D. Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB. J Biol Chem 281: 15090-15098, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 15090-15098
-
-
Popov, Y.1
Patsenker, E.2
Bauer, M.3
Niedobitek, E.4
Schulze-Krebs, A.5
Schuppan, D.6
-
17
-
-
39149111929
-
Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies
-
Popov Y, Patsenker E, Stickel F, Zaks J, Bhaskar KR, Niedobitek G, Kolb A, Friess H, Schuppan D. Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies. J Hepatol 48: 453-464, 2008.
-
(2008)
J Hepatol
, vol.48
, pp. 453-464
-
-
Popov, Y.1
Patsenker, E.2
Stickel, F.3
Zaks, J.4
Bhaskar, K.R.5
Niedobitek, G.6
Kolb, A.7
Friess, H.8
Schuppan, D.9
-
18
-
-
77249139206
-
Macrophagemediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis
-
Popov Y, Sverdlov DY, Bhaskar KR, Sharma AK, Millonig G, Patsenker E, Krahenbuhl S, Krahenbuhl L, Schuppan D. Macrophagemediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis. Am J Physiol Gastrointest Liver Physiol 298: G323-G334, 2010.
-
(2010)
Am J Physiol Gastrointest Liver Physiol
, vol.298
-
-
Popov, Y.1
Sverdlov, D.Y.2
Bhaskar, K.R.3
Sharma, A.K.4
Millonig, G.5
Patsenker, E.6
Krahenbuhl, S.7
Krahenbuhl, L.8
Schuppan, D.9
-
19
-
-
54549119172
-
Current and future anti-fibrotic therapies for chronic liver disease
-
Rockey DC. Current and future anti-fibrotic therapies for chronic liver disease. Clin Liver Dis 12: 939-965, 2008.
-
(2008)
Clin Liver Dis
, vol.12
, pp. 939-965
-
-
Rockey, D.C.1
-
20
-
-
33645798836
-
Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice
-
Roderfeld M, Weiskirchen R, Wagner S, Berres ML, Henkel C, Grötzinger J, Gressner AM, Matern S, Roeb E. Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice. FASEB J 20: 444-454, 2006.
-
(2006)
FASEB J
, vol.20
, pp. 444-454
-
-
Roderfeld, M.1
Weiskirchen, R.2
Wagner, S.3
Berres, M.L.4
Henkel, C.5
Grötzinger, J.6
Gressner, A.M.7
Matern, S.8
Roeb, E.9
-
21
-
-
10644226862
-
Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice
-
Sakaida I, Terai S, Yamamoto N, Aoyama K, Ishikawa T, Nishina H, Okita K. Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology 40: 1304-1311, 2004.
-
(2004)
Hepatology
, vol.40
, pp. 1304-1311
-
-
Sakaida, I.1
Terai, S.2
Yamamoto, N.3
Aoyama, K.4
Ishikawa, T.5
Nishina, H.6
Okita, K.7
-
22
-
-
77951874018
-
Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
-
Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, Neuschwander-Tetri BA, Lavine JE, Tonascia J, Unalp A, Van Natta M, Clark J, Brunt EM, Kleiner DE, Hoofnagle JH, Robuck PR; NASH CRN. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 362: 1675-1685, 2010.
-
(2010)
N Engl J Med
, vol.362
, pp. 1675-1685
-
-
Sanyal, A.J.1
Chalasani, N.2
Kowdley, K.V.3
McCullough, A.4
Diehl, A.M.5
Bass, N.M.6
Neuschwander-Tetri, B.A.7
Lavine, J.E.8
Tonascia, J.9
Unalp, A.10
van Natta, M.11
Clark, J.12
Brunt, E.M.13
Kleiner, D.E.14
Hoofnagle, J.H.15
Robuck, P.R.16
Nash, C.R.N.17
-
23
-
-
11144357753
-
Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis
-
Siller-Lopex F, Sandoval A, Salgado S, Salazar A, Bueno M, Garcia J, Vera J, Gálvez J, Hernández I, Ramos M, Aguilar-Cordova E, Armendariz-Borunda J. Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis. Gastroenterology 126: 1122-1133, 2004.
-
(2004)
Gastroenterology
, vol.126
, pp. 1122-1133
-
-
Siller-Lopex, F.1
Sandoval, A.2
Salgado, S.3
Salazar, A.4
Bueno, M.5
Garcia, J.6
Vera, J.7
Gálvez, J.8
Hernández, I.9
Ramos, M.10
Aguilar-Cordova, E.11
Armendariz-Borunda, J.12
-
24
-
-
74949133886
-
Antifibrotic therapies-emerging biomarkers as treatment end points
-
Talwalker JA. Antifibrotic therapies-emerging biomarkers as treatment end points. Nat Rev Gastroenterol Hepatol 7: 59-61, 2010.
-
(2010)
Nat Rev Gastroenterol Hepatol
, vol.7
, pp. 59-61
-
-
Talwalker, J.A.1
-
25
-
-
62749084923
-
Accelerative effect of leflunomide on recovery from hepatic fibrosis involves TRAIL-mediated hepatic stellate cell apoptosis
-
Tang X, Yang J, Li J. Accelerative effect of leflunomide on recovery from hepatic fibrosis involves TRAIL-mediated hepatic stellate cell apoptosis. Life Sci 84: 552-557, 2009.
-
(2009)
Life Sci
, vol.84
, pp. 552-557
-
-
Tang, X.1
Yang, J.2
Li, J.3
-
26
-
-
33745003240
-
CB1 cannabinoid receptor antagonism: A new strategy for the treatment of liver fibrosis
-
Teixeira-Clerc F, Julien B, Grenard P, Tran Van Nhieu J, Deveaux V, Li L, Serriere-Lanneau V, Ledent C, Mallat A, Lotersztajn S. CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Nat Med 12: 671-676, 2006.
-
(2006)
Nat Med
, vol.12
, pp. 671-676
-
-
Teixeira-Clerc, F.1
Julien, B.2
Grenard, P.3
Tran van Nhieu, J.4
Deveaux, V.5
Li, L.6
Serriere-Lanneau, V.7
Ledent, C.8
Mallat, A.9
Lotersztajn, S.10
-
27
-
-
58049127190
-
Current status of autologous bone marrow cell infusion therapy for liver cirrhosis patients
-
Terai S, Sakaida I. Current status of autologous bone marrow cell infusion therapy for liver cirrhosis patients. Hepatol Res 38: S72-S75, 2008.
-
(2008)
Hepatol Res
, vol.38
-
-
Terai, S.1
Sakaida, I.2
-
28
-
-
77956268976
-
Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells
-
Trebicka J, Hennenberg M, Odenthal M, Shir K, Klein S, Granzow M, Vogt A, Dienes HP, Lammert F, Reichen J, Heller J, Sauerbruch T. Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells. J Hepatol 53: 702-712, 2010.
-
(2010)
J Hepatol
, vol.53
, pp. 702-712
-
-
Trebicka, J.1
Hennenberg, M.2
Odenthal, M.3
Shir, K.4
Klein, S.5
Granzow, M.6
Vogt, A.7
Dienes, H.P.8
Lammert, F.9
Reichen, J.10
Heller, J.11
Sauerbruch, T.12
-
29
-
-
72949123737
-
Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis
-
Witek RP, Stone WC, Karaca FG, Syn WK, Pereira TA, Agboola KM, Omenetti A, Jung Y, Teaberry V, Choi SS, Guy CD, Pollard J, Charlton P, Diehl AM. Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. Hepatology 50: 1421-1430, 2009.
-
(2009)
Hepatology
, vol.50
, pp. 1421-1430
-
-
Witek, R.P.1
Stone, W.C.2
Karaca, F.G.3
Syn, W.K.4
Pereira, T.A.5
Agboola, K.M.6
Omenetti, A.7
Jung, Y.8
Teaberry, V.9
Choi, S.S.10
Guy, C.D.11
Pollard, J.12
Charlton, P.13
Diehl, A.M.14
-
30
-
-
21844457440
-
Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice
-
Yang L, Bataller R, Dulyx J, Coffman TM, Ginès P, Rippe RA, Brenner DA. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J Hepatol 43: 317-323, 2005.
-
(2005)
J Hepatol
, vol.43
, pp. 317-323
-
-
Yang, L.1
Bataller, R.2
Dulyx, J.3
Coffman, T.M.4
Ginès, P.5
Rippe, R.A.6
Brenner, D.A.7
|