Oridonin induces the apoptosis of metastatic hepatocellular carcinoma cells via a mitochondrial pathway

Oncology Letters

Volumn 6, Issue 5, 2013, Pages 1502-1506

  Zhu, Min ^a   Hong, Dun ^a   Bao, Yanfang ^b   Wang, Chen ^a   Pan, Weibo ^b  

^a TAIZHOU HOSPITAL OF ZHEJIANG PROVINCE   (China)

^b TAIZHOU UNIVERSITY   (China)

Author keywords

Apoptosis; MHCC97 H cells; Mitochondrial pathway; Oridonin

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; ORIDONIN; PROTEIN BAX; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; NECROSIS; PROTEIN EXPRESSION; WESTERN BLOTTING;

EID: 84884486558     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2013.1541     Document Type: Article

References (23)

1. Barazani Y, Hiatt JR, Tong MJ and Busuttil RW: Chronic viral hepatitis and hepatocellular carcinoma. World J Surg 31: 1243-1248, 2007.
2. Fancellu A, Rosman AS, Sanna V, Nigri GR, Zorcolo L, Pisano M and Melis M: Meta-analysis of trials comparing minimally-invasive and open liver resections for hepatocellular carcinoma. J Surg Res 171: e33-e45, 2011.
3. Bruix J and Sherman M: Management of hepatocellular carcinoma: an update. Hepatology53: 1020-1022, 2011.
4. Meade-Tollin LC, Wijeratne EM, Cooper D, et al: Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES. J Nat Prod 67: 2-4, 2004.
5. Sartippour MR, Seeram NP, Heber D, et al: Rabdosia rubescens inhibits breast cancer growth and angiogenesis. Int J Oncol26: 121-127, 2005.
6. Hsieh TC, Wijeratne EK, Liang JY, Gunatilaka AL and WuJM: Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 byponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens. Biochem Biophys Res Commun 337: 224-231, 2005.
7. Liu YQ, Mu ZQ, You S, Tashiro S, Onodera S and Ikejima T: Fas/FasL signaling allows extracelluar-signal regulated kinase to regulate cytochrome c release in oridonin-induced apoptotic U937 cells. Biol Pharm Bull 29: 1873-1879, 2006.
8. Li B, Zhu M, Wang C, et al: Oridonin upregulates PTEN gene expression and induces apoptosis of HepG2 cells. Herald of Medicine 9: 6, 2008.
9. Huang J, Wu L, Tashiro S, Onodera S and Ikejima T: Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways. J Pharmacol Sci 107: 370-379, 2008.
10. Xu Z, Zhou X, Lu H, et al: Comparative glycoproteomics based on lectins affinity capture of N-linked glycoproteins from human Chang liver cells and MHCC97-H cells. Proteomics7: 2358-2370, 2007.
11. Sun H and Liu GT: Inhibitory effect of anti-hepatitis drug bicyclol on invasion of human hepatocellular carcinoma MHCC97-H cells with high metastasis potential and its relative mechanisms. J Asian Nat Prod Res 11: 576-583, 2009.
12. Tian J, Tang Z and Ye S: Establishment of a human hepatocellular carcinoma (HCC) cell line with high metastatic potential (MHCC97) and its biological characteristics. Zhonghua Zhong Liu Za Zhi 20: 405-407, 1998 (In Chinese).
13. Xiao SH, Xue J and Zhang HB: Further studies on mefloquine and praziquantel alone or interaction of both drugs against Schistosoma japonicum in vitro. Parasitol Res 110: 1239-1248, 2011.
14. Zhang Y, Hu MY, Wu WZ, Wang ZJ, Zhou K, Zha XL and LiuKD: The membrane-cytoskeleton organizer ezrin is necessary for hepatocellular carcinoma cell growth and invasiveness. J Cancer Res Clin Oncol 132: 685-697, 2006.
15. Salminen A, Ojala J and Kaarniranta K: Apoptosis and aging: increased resistance to apoptosis enhances the aging process. Cell Mol Life Sci 68: 1021-1031, 2011.
16. Brenner C, Subramaniam K, Pertuiset C and Pervaiz S: Adenine nucleotide translocase family: four isoforms for apoptosis modulation in cancer. Oncogene 30: 883-895, 2011.
17. Dunkle A and He YW: Apoptosis and autophagy in the regulation of T lymphocyte function. Immunol Res 49: 70-86, 2011.
18. Hellwig CT, Passante E and Rehm M: The molecular machinery regulating apoptosis signal transduction and its implication in human physiology and pathophysiologies. Curr Mol Med11: 31-47, 2011.
19. Sevrioukova IF: Apoptosis-inducing factor: structure, function, and redox regulation. Antioxid Redox Signal 14: 2545-2579, 2011.
20. Sayeed I, Parvez S, Winkler-Stuck K, et al: Patch clamp reveals powerful blockade of the mitochondrial permeability transition pore by the D2-receptor agonist pramipexole. FASEB J20: 556-558, 2006.
21. Feng R, Han J, Ziegler J, Yang M and Castranova V: Apaf-1 deficiency confers resistance to ultraviolet-induced apoptosis in mouse embryonic fibroblasts by disrupting reactive oxygen species amplification production and mitochondrial pathway. Free Radic Biol Med 52: 889-897, 2012.
22. Ola MS, Nawaz M and Ahsan H: Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Mol Cell Biochem351: 41-58, 2011.
23. Reed JC: Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities. Cell Death Differ 13: 1378-1386, 2006.