Lipid rescue: Does the sink hold water? And other controversies

British Journal of Anaesthesia

Volumn 112, Issue 4, 2014, Pages 622-625

  Harvey, M ^a   Cave, G ^b  

^a WAIKATO HOSPITAL   (New Zealand)

^b HUTT HOSPITAL   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ANESTHETIC AGENT; ANTIARRHYTHMIC AGENT; ANTIDOTE; BUPIVACAINE; CALCIUM CHANNEL BLOCKING AGENT; HYPERTENSIVE FACTOR; LIPID EMULSION; LOCAL ANESTHETIC AGENT; MEPIVACAINE; ROPIVACAINE; XENOBIOTIC AGENT;

ARTIFICIAL VENTILATION; CALCIUM HOMEOSTASIS; CORONARY ARTERY BLOOD FLOW; HEART ARREST; INTOXICATION; LD 50; LIPOPHILICITY; NONHUMAN; PRIORITY JOURNAL; REGIONAL ANESTHESIA; RESUSCITATION; REVIEW;

ANESTHETICS, LOCAL; ANIMALS; BUPIVACAINE; EMULSIONS; EPINEPHRINE; FAT EMULSIONS, INTRAVENOUS; FEMALE; HEART; HEART ARREST; MALE; MEPIVACAINE; PHOSPHOLIPIDS; SOYBEAN OIL;

EID: 84896958396     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aeu010     Document Type: Editorial

References (40)

1. Weinberg G, VadeBoncouer T, Ramaraju G, Garcia-AmaroM, Cwik M. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anaesthesiology 1998; 88: 1071-5
2. Weinberg G, Ripper R, Feinstein D, HoffmanW. Lipid emulsion infusion rescues dogs from bupivacaine induced cardiac toxicity. Reg Anesth Pain Med 2003; 28: 198-202
3. Tebbutt S, Harvey M, Nicholson T, CaveG. Intralipidprolongs survival in a ratmodel of verapamil toxicity. Acad Emerg Med 2006; 13: 134-9
4. Bania T, Chu J, Perez E. Hemodynamic effects of intravenous fat emulsion in an animal model of severe verapamil toxicity resuscitated with atropine, calcium, and saline. Acad Emerg Med 2007; 14: 105-11
5. Bania T, Chu J. Hemodynamic effect of intralipid in amitriptyline toxicity. Acad Emerg Med 2006; 13(Suppl. 1): 117
6. Harvey M, Cave G. Intralipid outperforms sodium bicarbonate in a rabbit model of clomipramine toxicity. Ann Emerg Med 2007; 49: 178-85
7. Krieglstein J, Meffert A, Niemeyer D. Influence of emulsified fat on chlorpromazineavailability inrabbit blood.Experientia1974;15:924-6
8. Bania T, Chu J, Wesolowski M. The hemodynamic effect of Intralipid on propranolol toxicity. Acad Emerg Med 2006; 13(Suppl. 1): 109
9. Niiya T, Litonius E, Petaja L, Neuvonen P, Rosenburg P. Intravenous lipid emulsion sequesters amiodarone in plasma and eliminates its hypotensive action in pigs. Ann Emerg Med 2010; 56: 402-8
10. Rosenblatt M, Abel M, Fischer G, Itzkovich C, Eisenkraft J. Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology 2006; 105: 217-8
11. Foxall G, McCahon R, Lamb J, Hardman J, Bedforth N. Levobupivacaine- induced seizures and cardiovascular collapse treated with Intralipid. Anaesthesia 2007; 62: 516-8
12. Lin E, Aronson L. Successful resuscitation of bupivacaine induced cardiotoxicity in a neonate. Paediatr Anaesth 2101; 20: 955-7
13. Shah S, Gopalakrishnan S, Apuya J, Shah S, Martin T. Use of intralipid inaninfant with impendingcardiovascular collapsedueto local anesthetic toxicity. J Anesth 2009; 23: 439-41
14. Weinberg G, Di Gregorio G, Hiller D, Hewett A, Sirianni A. Reversal of haloperidol induced cardiac arrest by using lipid emulsion. Ann Intern Med 2009; 19: 737-8
15. Sirianni A, Osterhoudt K, Calello D, et al. Use of Intralipid in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med. 2007; 51: 412-5
16. Guidelines for theManagement of Severe Local-Anaesthetic Toxicity. The Association of Anaesthestists of Great Britain and Ireland. Available from http://www.aagbi.org/publications/guidelines/ docs/latoxicity07.pdf (accessed September 2013
17. Neal JM, Bernards CM, Butterworth JF, et al. ASRA practice advisory on local anesthetic systemic toxicity.Reg Anesth PainMed2010;35: 152-61
18. American College of Medical Toxicology. ACMT Position statement: Interimguidancefor theuseof lipid resuscitation therapy. JMedTox 2011; 7: 81-2
19. Buckley N, Dawson A. The intralipid genie is out of the bottle-spin and wishful thinking. Anaesth Intensive Care 2013; 41: 154-6
20. De Queiroz Siqueira M, Chassard D, Musard H, et al. Resuscitation with lipid, epinephrine, or both in levobupivacaine-induced cardiac toxicity in newborn piglets. Br J Anaesth 2014; 112: 729-34
21. Weinberg G, Di Gregorio G, Ripper R, et al. Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose. Anesthesiology 2008; 108: 907-13
22. Di Gregorio G, Schwartz D, Ripper R, et al. Lipid emulsion is superior to vasopressin in a rodent model of resuscitation from toxin induced cardiac arrest. Crit Care Med 2009; 37: 993-9
23. Hiller D, Gregorio G, Ripper R, et al. Epinephrine impairs lipid resuscitation from bupivacaine overdose: A threshold effect. Anesthesiology 2009; 111: 498-505
24. Li B, Yan J, Shen Y, Li B, Hu Z, Ma Z. Association of sustained cardiovascular recovery with epinephrine in the delayed lipid-based resuscitation from cardiac arrest induced by bupivacaine overdose in rats. Br J Anaesth 2012; 108: 857-63
25. Mauch J, Jurado O, Spielmann N, Bettschart-Wolfensberger R, Weiss M. Resuscitation strategies from bupivacaine induced cardiac arrest. Paediatr Anaesth 2012; 22: 124-9
26. Mayr V, Mitterschiffhaler L, Neurauter A, et al. A comparison of the combination of epinephrine and vasopressin with lipid emulsion in a porcine model of asphyxial cardiac arrest after intravenous injection of bupivacaine. Anesth Analg 2008; 106: 1566-71
27. Mauch J, Martin Jurado O, Spielmann N, Bettschart-Wolfensberger R, Weiss M. Comparison of epinephrine vs lipid rescue to treat severe local anesthetic toxicity-An experimental study in piglets. Paediatr Anaesth 2011; 21: 1103-8
28. Liu L, Xia Y, Chen Y. The comparative effects of lipid, epinephrine, and their combination in the reversal of bupivacaine induced asystole in the isolated rat heart. Anesth Analg 2012; 114: 886-93
29. Carreiro S, Blum J, Jay G, Hack J. Intravenous lipid emulsion alters the hemodynamic response to epinephrine in a rat model. J Med Toxicol 2013; 9: 220-5
30. Niiya T, Litonius E, Petaja L, Neuvonen P, Rosenberg P. Intravenous lipid emulsion sequesters amiodarone in plasma and eliminates its hypotensive action in pigs. Ann Emerg Med 2010; 56: 401-8
31. Aumeier C, Kasdorf B, Gruber M, et al. Lipid emulsion pretreatment has different effects on mepivacaine and bupivacaine cardiac toxicity in an isolated rat heart model. Br J Anaesth 2014; 112: 735-41
32. Weinberg G. Lipid rescue resuscitation from local anaesthetic cardiac toxicity. Toxicol Rev 2006; 25: 139-45
33. Weinberg G, Ripper R, Murphy P, et al. Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart. Reg Anesth Pain Med 2006; 31: 296-303
34. Ruan W, French D, Wong A, Drasner K, Wu A. A mixed (long and medium chain) triglyceride lipid emulsion extracts local anesthetic fromhumanserumin vitromore effectively thanalong chain emulsion. Anesthesiology 2012; 116: 334-9
35. Shi K, Xia Y, Wand Q, et al. The effect of lipid emulsion on pharmacokinetics and tissue distribution of bupivacaine in rats. Aneth Analg 2013; 116: 804-9
36. Stehr S, Ziegeler J, Pexa A, et al. The effects of lipid infusion onmyocardial function and bioenergetics in l-bupivacaine toxicity in the isolated rat heart. Anesth Analg 2007; 104: 186-92
37. Fettiplace M, Ripper R, Lis K, et al. Rapid cardiotonic effects of lipid emulsion infusion. Crit Care Med 2013; 41: 156-62
38. Bania T, Chu J, Lyon T, Yoon J. The role of cardiac free fatty acid metabolism in verapamil toxicity treated with intravenous fat emulsions. Acad Emerg Med 2007; 14: 196-7
39. Partownavid P, Umar S, Li J, Rahman S, Eghbali M. Fatty-Acid oxidation and calcium homeostasis are involved in the rescue of bupivacaine induced cardiotoxicity by lipid emulsion in rats. Crit Care Med 2012; 40: 2431-7
40. Nadrowitz F, Stoetzer C, Foadi N, et al. The distinct effects of lipid emulsions used for lipid resuscitation on gating and bupivacaine induced inhibition of the cardiac sodium channel Nav1.5. Anesth Analg 2013; 117: 1101-8.