A mixed (long- and medium-chain) triglyceride lipid emulsion extracts local anesthetic from human serum in vitro more effectively than a long-chain emulsion

Anesthesiology

Volumn 116, Issue 2, 2012, Pages 334-339

  Ruan, Weiming ^a   French, Deborah ^a   Wong, Alicia ^b   Drasner, Kenneth ^a   Wu, Alan H B ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; LIPID EMULSION; MEPIVACAINE; ROPIVACAINE; TRIACYLGLYCEROL;

ARTICLE; BLOOD SAMPLING; DRUG BLOOD LEVEL; HUMAN; HUMAN TISSUE; IN VITRO STUDY; PH; PRIORITY JOURNAL;

ANESTHETICS, LOCAL; DRUG COMBINATIONS; EMULSIONS; FAT EMULSIONS, INTRAVENOUS; HUMANS; PHOSPHOLIPIDS; SORBITOL; SOYBEAN OIL; TREATMENT OUTCOME; TRIGLYCERIDES;

EID: 84856421313     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e318242a5f1     Document Type: Article

References (24)

1. Weinberg GL, VadeBoncouer T, Ramaraju GA, Garcia-Amaro MF, Cwik MJ: Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology 1998; 88:1071-5 (Pubitemid 28193335)
2. Weinberg G, Ripper R, Feinstein DL, Hoffman W: Lipidemulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med 2003; 28:198-202 (Pubitemid 36618312)
3. Rosenblatt MA, Abel M, Fischer GW, Itzkovich CJ, Eisenkraft JB: Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology 2006; 105:217-8 (Pubitemid 44305211)
4. Litz RJ, Popp M, Stehr SN, Koch T: Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion. Anaesthesia 2006; 61:800-1 (Pubitemid 44027411)
5. Smith HM, Jacob AK, Segura LG, Dilger JA, Torsher LC: Simulation education in anesthesia training: A case report of successful resuscitation of bupivacaine-induced cardiac arrest linked to recent simulation training. Anesth Analg 2008; 106:1581-4 (Pubitemid 351571098)
6. Warren JA, Thoma RB, Georgescu A, Shah SJ: Intravenous lipid infusion in the successful resuscitation of local anesthetic-induced cardiovascular collapse after supraclavicular brachial plexus block. Anesth Analg 2008; 106:1578-80 (Pubitemid 351571097)
7. Ludot H, Tharin JY, Belouadah M, Mazoit JX, Malinovsky JM: Successful resuscitation after ropivacaine and lidocaine-induced ventricular arrhythmia following posterior lumbar plexus block in a child. Anesth Analg 2008; 106:1572-4 (Pubitemid 351571095)
8. Litz RJ, Roessel T, Heller AR, Stehr SN: Reversal of central nervous system and cardiac toxicity after local anesthetic intoxication by lipid emulsion injection. Anesth Analg 2008; 106:1575-7 (Pubitemid 351571096)
9. Foxall G, McCahon R, Lamb J, Hardman JG, Bedforth NM: Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid. Anaesthesia 2007; 62:516-8 (Pubitemid 46915706)
10. Spence AG: Lipid reversal of central nervous system symptoms of bupivacaine toxicity. Anesthesiology 2007; 107:516-7 (Pubitemid 47329558)
11. Mazoit JX, Le Guen R, Beloeil H, Benhamou D: Binding of long-lasting local anesthetics to lipid emulsions. Anesthesiology 2009; 110:380-6
12. Laine J, Lokajová J, Parshintsev J, Holopainen JM, Wiedmer SK: Interaction of a commercial lipid dispersion and local anesthetics in human plasma: Implications for drug trapping by ælipid-sinks. Anal Bioanal Chem 2010; 396:2599-607
13. Neal JM, Bernards CM, Butterworth JF 4th, Di Gregorio G, Drasner K, Hejtmanek MR, Mulroy MF, Rosenquist RW, Weinberg GL: ASRA practice advisory on local anesthetic systemic toxicity. Reg Anesth Pain Med 2010; 35:152-61
14. Cheng T, Zhao Y, Li X, Lin F, Xu Y, Zhang X, Li Y, Wang R, Lai L: Computation of octanol-water partition coefficients by guiding an additive model with knowledge. J Chem Inf Model 2007; 47:2140-8 (Pubitemid 350275080)
15. Strichartz GR, Sanchez V, Arthur GR, Chafetz R, Martin D: Fundamental properties of local anesthetics II. Measured octanol:buffer partition coefficients and pKa values of clinically used drugs. Anesth Analg 1990; 71:58-70
16. Denson D, Coyle D, Thompson G, Myers J: Alpha 1-acid glycoprotein and albumin in human serum bupivacaine binding. Clin Pharmacol Ther 1984; 35:409-15 (Pubitemid 14174149)
17. Mazoit JX, Cao LS, Samii K: Binding of bupivacaine to human serum proteins, isolated albumin and isolated alpha-1-acid glycoprotein. Differences between the two enantiomers are partly due to cooperativity. J Pharmacol Exp Ther 1996; 276:109-15 (Pubitemid 26150954)
18. Baselt RC: Disposition of Toxic Drugs and Chemicals in Man, 7th edition. Foster City, CA, Biomedical Publications, 2004
19. Zausig YA, Zink W, Keil M, Sinner B, Barwing J, Wiese CH, Graf BM: Lipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaine-or mepivacaine-induced cardiac arrest. Anesth Analg 2009; 109:1323-6
20. Hiller DB, Di Gregorio G, Kelly K, Ripper R, Edelman L, Boumendjel R, Drasner K, Weinberg GL: Safety of high volume lipid emulsion infusion: A first approximation of LD50 in rats. Reg Anesth Pain Med 2010; 35:140-4
21. Marwick PC, Levin AI, Coetzee AR: Recurrence of cardiotoxicity after lipid rescue from bupivacaine-induced cardiac arrest. Anesth Analg 2009; 108:1344-6
22. Calenda E, Dinescu SA: Failure of lipid emulsion to reverse neurotoxicity after an ultrasound-guided axillary block with ropivacaine and mepivacaine. J Anesth 2009; 23:472-3
23. Vanden Hoek TL, Morrison LJ, Shuster M, Donnino M, Sinz E, Lavonas EJ, Jeejeebhoy FM, Gabrielli A: Part 12: cardiac arrest in special situations: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2010; 122:S843
24. Cave G, Harvey M: Intravenous lipid emulsion as antidote beyond local anesthetic toxicity: A systematic review. Acad Emerg Med 2009; 16:815-24