Resuscitation strategies from bupivacaine-induced cardiac arrest

Paediatric Anaesthesia

Volumn 22, Issue 2, 2012, Pages 124-129

  Mauch, Jacqueline ^a,b   Jurado, Olga Martin ^c   Spielmann, Nelly ^a   Bettschart Wolfensberger, Regula ^c   Weiss, Markus ^a  

^a UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^b Kantonsspital Aarau ^*  (Switzerland)

^c VETSUISSE FACULTY UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

anesthetics local; bupivacaine; complication; epinephrine; lipid; local anesthetics; resuscitation; toxicity

Indexed keywords

ADRENALIN; BUPIVACAINE; INTRALIPID; OXYGEN; SEVOFLURANE; VASOPRESSIN;

ANESTHESIA INDUCTION; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; CENTRAL VENOUS CATHETER; ENDOTRACHEAL INTUBATION; HEART ARREST; NONHUMAN; PIGLET; PRIORITY JOURNAL; REACTION TIME; RESUSCITATION; SURVIVAL RATE;

ANESTHETICS, LOCAL; ANIMALS; BLOOD GAS ANALYSIS; BLOOD PRESSURE; BUPIVACAINE; CARDIOPULMONARY RESUSCITATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; EMULSIONS; EPINEPHRINE; FEMALE; HEART ARREST; MALE; MASS SPECTROMETRY; PHOSPHOLIPIDS; SOYBEAN OIL; SURVIVAL ANALYSIS; SWINE; TACHYCARDIA, VENTRICULAR; VASOCONSTRICTOR AGENTS; VASOPRESSINS; VENTRICULAR FIBRILLATION;

EID: 84855344838     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/j.1460-9592.2011.03688.x     Document Type: Article

References (20)

1. Leskiw U, Weinberg GL,. Lipid resuscitation for local anesthetic toxicity: is it really lifesaving? Curr Opin Anaesthesiol 2009; 22: 667-671.
2. Spence AG,. Lipid reversal of central nervous system symptoms of bupivacaine toxicity. Anesthesiology 2007; 107: 516-517. (Pubitemid 47329558)
3. Whiteside J,. Reversal of local anaesthetic induced CNS toxicity with lipid emulsion. Anaesthesia 2008; 63: 203-204.
4. Weinberg GL, VadeBoncouer T, Ramaraju GA, et al. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology 1998; 88: 1071-1075. (Pubitemid 28193335)
5. Weinberg G, Ripper R, Feinstein DL, et al. Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med 2003; 28: 198-202. (Pubitemid 36618312)
6. Mayr VD, Mitterschiffthaler L, Neurauter A, et al. A Comparison of the combination of epinephrine and vasopressin with lipid emulsion in a porcine model of asphyxial cardiac arrest after intravenous injection of bupivacaine. Anesth Analg 2008; 106: 1566-1571. (Pubitemid 351571094)
7. Hicks SD, Salcido DD, Logue ES, et al. Lipid emulsion combined with epinephrine and vasopressin does not improve survival in a swine model of bupivacaine-induced cardiac arrest. Anesthesiology 2009; 111: 138-146.
8. R Development Core Team. R: A Language and Environment for Statistical Computing. 2010; Vienna, Austria: R Foundation for Statistical Computing. ISBN 3-900051-07-0,.
9. Pinheiro J, Bates D, DebRoy S, et al. nlme: Linear and Nonlinear Mixed Effects Models. R Package Version 3. 2009: 1-96. Accessed 16 August 2011.
10. Zeileis A, Hothorn T,. Diagnostic Checking in Regression Relationships. R News 2002; 2: 7-10.
11. Picard J, Ward SC, Zumpe R, et al. Guidelines and the adoption of "lipid rescue" therapy for local anaesthetic toxicity. Anaesthesia 2009; 64: 122-125.
12. Woehlck HJ, El-Orbany M,. Anesthetic effects and lipid resuscitation protocols. Anesthesiology 2010; 112: 450-499.
13. Neumar RW, Otto CW, Link MS, et al. Part 8: adult advanced cardiovascular life support: 2010 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 2010; 122: 729-767.
14. Hiller DB, Di Gregorio G, Ripper R, et al. Epinephrine impairs lipid resuscitation from bupivacaine overdose. Anesthesiology 2009; 111: 498-505.
15. Ott K,. Lipid emulsion therapy for local anaesthetic toxicity: "LipidRescue". Anaesthesist 2010; 59: 575-586.
16. Scott DB,. Evaluation of the toxicity of local anaesthetic agents in man. Br J Anaesth 1975; 47: 56-61.
17. Levsky ME, Miller MA,. Cardiovascular collapse from low dose bupivacaine. Can J Clin Pharmacol 2005; 12: 240-245.
18. Rosenberg PH, Veering BT, Urmey WF,. Maximum recommended doses of local anesthetics: a multifactorial concept. Reg Anesth Pain Med 2004; 29: 564-575. (Pubitemid 40039994)
19. Udelsmann A, Lorena SE, Girioli SU, et al. Hemodynamic effects of local anesthetics intoxication. Experimental study in swine with levobupivacaine and bupivacaine. Acta Cir Bras 2008; 23: 55-64. (Pubitemid 351972483)
20. Nyström EUM, Heavner JE, Buffington CW,. Blood pressure is maintained despite profound myocardial depression during acute bupivacaine overdose in pigs. Anesth Analg 1999; 88: 1143-1148. (Pubitemid 29211555)