The comparative effects of lipid, epinephrine, and their combination in the reversal of bupivacaine-induced asystole in the isolated rat heart

Anesthesia and Analgesia

Volumn 114, Issue 4, 2012, Pages 886-893

  Liu, Le ^a   Xia, Yun ^b   Chen, Ying ^a,c   Wang, Quanguang ^a   Shi, Tong ^a   Wang, Fangyan ^a   Small, Robert H ^b   Xu, Xuzhong ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^c FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; BUPIVACAINE; INTRALIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASYSTOLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG INFUSION; HEART BEAT; HEART FUNCTION; HEART PERFUSION; ISOLATED HEART; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; TIME;

ANESTHETICS, LOCAL; ANIMALS; BUPIVACAINE; CORONARY CIRCULATION; ELECTROCARDIOGRAPHY; EPINEPHRINE; FAT EMULSIONS, INTRAVENOUS; HEART ARREST; MALE; RATS; RATS, SPRAGUE-DAWLEY; VENTRICULAR FUNCTION, LEFT;

EID: 84859072857     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e3182166a0a     Document Type: Article

References (18)

1. Weinberg GL, VadeBoncouer T, Ramaraju GA, Garcia-Amaro MF, Cwik MJ. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology 1998;88:1071-5 (Pubitemid 28193335)
2. Weinberg G, Ripper R, Feinstein DL, Hoffman W. Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med 2003;28:198-202 (Pubitemid 36618312)
3. Weinberg GL, Ripper R, Murphy P, Edelman LB, Hoffman W, Strichartz G, Feinstein DL. Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart. Reg Anesth Pain Med 2006;31:296-303 (Pubitemid 44062378)
4. Stehr SN, Ziegeler JC, Pexa A, Oertel R, Deussen A, Koch T, Hübler M. The effects of lipid infusion on myocardial function and bioenergetics in l-bupivacaine toxicity in the isolated rat heart. Anesth Analg 2007;104:186-92
5. Groban L, Deal DD, Vernon JC, James RL, Butterworth J. Cardiac resuscitation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine in anesthetized dogs. Anesth Analg 2001;92:37-43 (Pubitemid 32039174)
6. Heavner JE, Pitkänen MT, Shi B, Rosenberg PH. Resuscitation from bupivacaine-induced asystole in rats: comparison of different cardioactive drugs. Anesth Analg 1995;80:1134-9
7. Bernards CM, Carpenter RL, Kenter ME, Brown DL, Rupp SM, Thompson GE. Effect of epinephrine on central nervous system and cardiovascular system toxicity of bupivacaine in pigs. Anesthesiology 1989;71:711-7 (Pubitemid 19275092)
8. Neustein S, Sampson I, Dimich I, Shiang H, Tatu J. Milrinone is superior to epinephrine as treatment of myocardial depression due to ropivacaine in pigs. Can J Anaesth 2000;47:1114-8 (Pubitemid 34257266)
9. Hiller DB, Gregorio GD, Ripper R, Kelly K, Massad M, Edelman L, Edelman G, Feinstein DL, Weinberg GL. Epinephrine impairs lipid resuscitation from bupivacaine overdose: a threshold effect. Anesthesiology 2009;111:498-505
10. Cave G, Harvey MG, Winterbottom T. Evaluation of the Association of Anaesthetists of Great Britain and Ireland lipid infusion protocol in bupivacaine induced cardiac arrest in rabbits. Anaesthesia 2009;64:732-7
11. Chen Y, Xia Y, Liu L, Shi T, Shi K, Wang Q, Chen L, Papadimos TJ, Xu X. Lipid emulsion reverses bupivacaine-induced asystole in isolated rat hearts: concentration-response and time-response relationships. Anesthesiology 2010;113:1320-5
12. Heavner JE. Cardiac toxicity of local anesthetics in the intact isolated heart model: a review. Reg Anesth Pain Med 2002;27:545-55 (Pubitemid 35387141)
13. Feldman HS, Hartvig P, Wiklund L, Doucette AM, Antoni G, Gee A, Ulin J, Langstrom B. Regional distribution of 11C-labeled lidocaine, bupivacaine, and ropivacaine in the heart, lungs, and skeletal muscle of pigs studied with positron emission tomography. Biopharm Drug Dispos 1997;18:151-64 (Pubitemid 27165426)
14. Williamson JR. Metabolic effects of epinephrine in the isolated, perfused rat heart: I. Dissociation of the glycogenolytic from the metabolic stimulatory effect. J Biol Chem 1964;239:2721-9
15. Glomstein A, Hauge A, Oye I, Sinclair D. Effects of adrenaline on coronary flow in isolated perfused rat hearts. Acta Physiol Scand 1967;69:102-10
16. Rosenblatt MA, Abel M, Fischer GW, Itzkovich CJ, Eisenkraft JB. Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology 2006;105:217-8 (Pubitemid 44305211)
17. Butterworth JF 4th, Brownlow RC, Leith JP, Prielipp RC, Cole LR. Bupivacaine inhibits cyclic-3′,5′-adenosine monophosphate production. A possible contributing factor to cardiovascular toxicity. Anesthesiology 1993;79:88-95 (Pubitemid 23215153)
18. Weinberg GL, Di Gregorio G, Ripper R, Kelly K, Massad M, Edelman L, Schwartz D, Shah N, Zheng S, Feinstein DL. Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose. Anesthesiology 2008;108:907-13 (Pubitemid 351589487)