Resuscitation with lipid, epinephrine, or both in levobupivacaine-induced cardiac toxicity in newborn piglets

British Journal of Anaesthesia

Volumn 112, Issue 4, 2014, Pages 729-734

  De Queiroz Siqueira, M ^a   Chassard, D ^b   Musard, H ^a   Heilporn, A ^a   Cejka, J C ^a   Leveneur, O ^c   Allaouchiche, B ^b   Rhondali, O ^a  

^a Mère Enfant University Hospital   (France)

^b UNIVERSITÉ DE LYON   (France)

^c UNIVERSITÉ LYON 1   (France)

Author keywords

local anaesthesia; local anaesthetics; toxicity

Indexed keywords

ADRENALIN; INTRALIPID; LEVOBUPIVACAINE;

ANESTHESIA COMPLICATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOTOXICITY; CONTINUOUS INFUSION; CONTROLLED STUDY; ECG ABNORMALITY; ELECTROCARDIOGRAM; FEMALE; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; LOCAL ANESTHESIA; MALE; MANUAL VENTILATION; MEAN ARTERIAL PRESSURE; NEWBORN; NONHUMAN; PIGLET; PRIORITY JOURNAL; QRS COMPLEX; RESUSCITATION; RETURN OF SPONTANEOUS CIRCULATION; SHOCK; SINUS RHYTHM;

LOCAL ANAESTHESIA; TOXICITY, LOCAL ANAESTHETICS;

ANESTHETICS, LOCAL; ANIMALS; ANIMALS, NEWBORN; BUPIVACAINE; CARDIOPULMONARY RESUSCITATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; DRUG THERAPY, COMBINATION; ELECTROCARDIOGRAPHY; EMULSIONS; EPINEPHRINE; FAT EMULSIONS, INTRAVENOUS; FEMALE; HEART ARREST; MALE; PHOSPHOLIPIDS; SOYBEAN OIL; SUS SCROFA; VASOCONSTRICTOR AGENTS;

EID: 84896947478     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aet327     Document Type: Article

References (32)

1. Foxall G, McCahon R, Lamb J, Hardman JG, Bedforth NM. Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid. Anaesthesia 2007; 62: 516-8
2. Rosenblatt MA, Abel M, Fischer GW, Itzkovich CJ, Eisenkraft JB. Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology 2006; 105: 217-8
3. Ludot H, Tharin JY, Belouadah M, Mazoit JX, Malinovsky JM. Successful resuscitation after ropivacaine and lidocaine-induced ventricular arrhythmia following posterior lumbar plexus block in a child. Anesth Analg 2008; 106: 1572-4
4. ShahS, Gopalakrishnan S, Apuya J, Shah S, Martin T. Use of Intralipid inan infant with impending cardiovascular collapsedue to local anesthetic toxicity. J Anesth 2009; 23: 439-41
5. Ohmura S, Kawada M, Ohta T, Yamamoto K, Kobayashi T. Systemic toxicity and resuscitation in bupivacaine, levobupivacaine, or ropivacaine infused rats. Anesth Analg 2001; 93: 743-8
6. Mazoit JX, Decaux A, Bouaziz H, Edouard A. Comparative ventricular electrophysiologic effect of racemic bupivacaine, levobupivacaine, and ropivacaine on the isolated rabbit heart. Anesthesiology 2000; 93: 784-92
7. Dobereiner EF, Cox RG, Ewen A, Lardner DR. Evidence-based clinical update: Which local anesthetic drug for pediatric caudal block provides optimal efficacy with the fewest side effects? Can J Anaesth 2010; 57: 1102-10
8. Warren JA, Thoma RB, Georgescu A, Shah SJ. Intravenous lipid infusion in the successful resuscitation of local anesthetic induced cardiovascular collapse after supraclavicular brachial plexus block. Anesth Analg 2008; 106: 1578-80
9. Weinberg GL, VadeBoncouer T, Ramaraju GA. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology 1998; 88: 1071-5
10. Wong GK, Joo DT, McDonnell C. Lipid resuscitation in a carnitine deficient child following intravascular migration of an epidural catheter. Anaesthesia 2010; 65: 192-5
11. Picard J, Ward SC, Zumpe R, Meek T, Barlow J, Harrop-Griffiths W. Guidelines and the adoption of lipid rescue therapy for local anaesthetic toxicity. Anaesthesia 2009; 64: 122-5
12. Neal JM, Bernards CM, Butterworth JF IV. ASRA Practice advisory on local anesthetic systemic toxicity. Reg Anesth Pain Med 2010; 35: 152-61
13. Weinberg GL, Di Gregorio G, Ripper R, et al. Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose. Anesthesiology 2008; 108: 907-13
14. Hiller DB, Gregorio GD, Ripper R, et al. Epinephrine impairs lipid resuscitation from bupivacaine overdose: A threshold effect. Anesthesiology 2009; 111: 498-505
15. Prakash YS, Seckin I, Hunter LW, et al. Mechanisms underlying greater sensitivity of neonatal cardiac muscle to volatile anesthetics. Anesthesiology 2002; 96: 893-906
16. Baum VC, Palmisano BW. The immature heart and anesthesia. Anesthesiology 1997; 87: 1529-48
17. Ziino AJA, DaviesMW, Davis PG. Epinephrine for the resuscitation of apparently stillborn or extremely bradycardic newborn infants. Cochrane Database System Rev 2002; 3: 0-00
18. Nam J. A simple approximation for calculating sample sizes for detecting linear trend in proportions. Biometrics 1987; 43: 701-5
19. Di Gregorio G, Neal JM, Rosenquist RW, Weinberg GL. Clinical presentation of local anesthetic systemic toxicity: A review of published cases, 1979 to 2009. Reg Anesth Pain Med 2010; 35: 181-7
20. Auroy Y, Narchi P, Messiah A, Litt L, Rouvier B, Samii K. Serious complications related to regional anesthesia: Results of a prospective survey in France. Anesthesiology 1997; 87: 479-86
21. Barrington MJ, Watts SA, Gledhill SR, et al. Preliminary results of the Australasian Regional Anaesthesia Collaboration: A prospective audit of more than 7000 peripheral nerve and plexus blocks for neurologic and other complications. Reg Anesth Pain Med 2009; 34: 534-41
22. Ecoffey C, Lacroix F, Giaufré E, Orliaguet G, Courrèges P; Association des Anesthésistes Reánimateurs Pédiatriques d'Expression Franc aise (ADARPEF). Epidemiology and morbidity of regional anesthesia in children: A follow-up one-year prospective survey of the French-Language Society of Paediatric Anaesthesiologists (ADARPEF). Paediatr Anaesth 2010; 20: 1061-9
23. Weinberg GL, Ripper R, Feinstein DL, HoffmanW. Lipid emulsion infusion rescues dogs frombupivacaine-induced cardiac toxicity. Reg Anesth Pain Med 2003; 28: 198-202
24. Mauch J, Jurado OM, Spielmann N, Bettschahart-Wolfensberg R, Weiss M. Comparison epinephrine vs lipid rescue to treat severe local anesthetic toxicity-An experimental study in piglets. Ped Anesth 2012; 22: 124-9
25. Mayr VD, Mitterschiffthaler L, Neurauter A, et al. A comparison of the combination of epinephrine and vasopressin with lipid emulsion in a porcine model of asphyxial cardiac arrest after intravenous injection of bupivacaine. Anesth Analg 2008; 106: 1566-71
26. Harvey M, Cave G, Prince G, Lahner D. Epinephrine injection in lipid-based resuscitation from bupivacaine-induced cardiac arrest: Transient circulatory return in rabbits. Anesth Analg 2010; 111: 791-96
27. Perondi MB, Reis AG, Paiva EF, Nadkarni VM, Berg RA. A comparison of high-dose and standard-dose epinephrine in children with cardiac arrest. N Engl J Med 2004; 350: 1722-30
28. Caspi J, Coles JG, Benson LN, et al. Age-related response to epinephrine-induced myocardial stress. A functional and ultrastructural study. Circulation 1991; 84: 394-9
29. Mazoit JX, Le Guen R, Beloeil H, Benhamou D. Binding of long-lasting local anesthetics to lipid emulsions. Anesthesiology 2009; 110: 380-6
30. Weinberg G, Rubinstein I. Pig in a poke: Species specificity in modeling lipid resuscitation. Anesth Analg 2012; 114: 907-9
31. Szebeni J, Bedó́cs P, Csukás D, Rosivall L, Bünger R, Urbanics R. A porcine model of complement-mediated infusion reactions to drug carrier nanosystems and other medicines. Adv Drug Deliv Rev 2012; 64: 1706-16
32. Crane C, Sagini E, Johnson AD, O'Sullivan J. International Scholarly Research Network, ISRN Anesthesiology, Hindawi. 2012; Article ID 905034: 1-5.